The development of a standardised diet history tool to support the diagnosis of food allergy

Review

Published: 19 February 2015
Abstract (provisional)

Isabel J Skypala^1*, Carina Venter², Rosan Meyer³, Nicolette W deJong⁴, Adam T Fox⁵,Marion Groetch⁶, J N Oude Elberink⁷, Aline Sprikkelman⁸, Louiza Diamandi⁹, Berber J Vlieg-Boerstra¹⁰ and the Allergy-focussed Diet History Task Force of the European Academy of Allergy and Clinical Immunology

Clinical and Translational Allergy 2015, 5:7  doi:10.1186/s13601-015-0050-2

The disparity between reported and diagnosed food allergy makes robust diagnosis imperative.

No evidence for altered intracellular calcium-handling in airway smooth muscle cells from human subjects with asthma

Research article

David Sweeney^12†, Fay Hollins^1†, Edith Gomez¹², Rajendra Mistry², Ruth Saunders¹,Robert Alfred John Challiss^2* and Christopher Edward Brightling^1*

BMC Pulmonary Medicine 2015, 15:12  doi:10.1186/s12890-015-0009-z

David Sweeney and Fay Hollins contributed equally to this work.

Published: 13 February 2015

Abstract (provisional)

Background 

Asthma is characterized by airway hyper-responsiveness and variable airflow obstruction, in part as a consequence of hyper-contractile airway smooth muscle, which persists in primary cell culture. One potential mechanism for this hyper-contractility is abnormal intracellular Ca2+ handling. 

Vitamin D deficiency in pregnancy and its impact on the fetus, the newborn and in childhood

• Marilyn Urrutia‐Pereira^, , 
• Dirceu Solé

doi:10.1016/j.rpped.2014.05.004

Open Access funded by Sociedade de Pediatria de São Paulo

Under a Creative Commons license

Abstract

Objective

Vitamin D deficiency (VDD) in pregnant women and their children is an important health problem with severe consequences for the health of both. Thus, the objectives of this review were to reassess the magnitude and consequences of VDD during pregnancy, lactation and infancy, associated risk factors, prevention methods, and to explore epigenetic mechanisms in early fetal life capable of explaining many of the non‐skeletal benefits of vitamin D (ViD).

Study of induction of Tolerance to Oral Peanut: a randomised controlled trial of desensitisation using peanut oral immunotherapy in children (STOP II)

Efficacy and Mechanism Evaluation, No. 1.4

Katherine Anagnostou, Sabita Islam, Yvonne King, Loraine Foley, Laura Pasea,Chris Palmer, Simon Bond, Pamela Ewan, and Andrew Clark.

Author Information

Southampton (UK): NIHR Journals Library; 2014 Dec.

Effect of once-daily indacaterol maleate/mometasone furoate on exacerbation risk in adolescent and adult asthma: a double-blind randomised controlled trial

BMJ Open. 2015 Feb 3;5(2):e006131. doi: 10.1136/bmjopen-2014-006131.

Beasley RW1, Donohue JF2, Mehta R3, Nelson HS4, Clay M5, Moton A6, Kim HJ6, Hederer BM7.

Author information

Abstract

OBJECTIVE:

To investigate the safety and efficacy of QMF149, a once-daily, fixed-dose combination of the long-acting β2-agonist (LABA) indacaterol maleate and inhaled corticosteroid (ICS) mometasone furoate (MF) for the treatment of persistent asthma. The hypothesis was that QMF149 would not increase the risk of serious asthma exacerbations.

Oral antiplatelet agent hypersensitivity and cross-reactivity managed by successful desensitisation

Asia Pac Allergy. 2015 Jan;5(1):51-4. doi: 10.5415/apallergy.2015.5.1.51. Epub 2015 Jan 28.

Chin N1, Rangamuwa K1, Mariasoosai R1, Carnes J1, Thien F2.

Author information

• 1Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia.
• 2Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia. ; Professor of Respiratory Medicine, Allergy and Immunology, Monash University, Melbourne, Victoria 3145, Australia.

Abstract

Oral platelet aggregation inhibitors are widely used for the treatment and prevention of cardiovascular diseases, including coronary stent thrombosis. Premature discontinuation following percutaneous coronary intervention would pose a grave risk of in-stent thrombosis, acute myocardial infarction and eventual death.

Obesity Increases Airway Hyperresponsiveness via the TNF-α Pathway and Treating Obesity Induces Recovery

PLoS One. 2015 Feb 6;10(2):e0116540. doi: 10.1371/journal.pone.0116540. eCollection 2015.

Kim JY1, Sohn JH2, Lee JH2, Park JW2.

Author information

Abstract

Obesity is a known risk factor for allergic asthma. It has been recognized as a key player in the pathogenesis of several inflammatory disorders via activation of macrophages, which is also vital to the development of allergic asthma. We investigated the mechanism of obesity-related asthma and whether treating obesity through exercise or diet ameliorates the severity of asthma in the obesity-related asthma model.

A randomised dose-ranging study of tiotropium Respimat ® in children with symptomatic asthma despite inhaled corticosteroids

Research

Published: 7 February 2015

Christian Vogelberg^1*, Petra Moroni-Zentgraf², Migle Leonaviciute-Klimantaviciene³, Ralf Sigmund⁴, Eckard Hamelmann⁵, Michael Engel² and Stanley Szefler⁶

Respiratory Research 2015, 16:20  doi:10.1186/s12931-015-0175-9

Abstract (provisional)

Background 

A considerable number of children with asthma remain symptomatic despite treatment with inhaled corticosteroids, resulting in significant morbidity, reduced quality of life, increased healthcare costs and lost school days. The aim of our study was to assess the efficacy, safety and tolerability of once-daily tiotropium Respimat 5µg, 2.5µg and 1.25µg add-on to medium-dose inhaled corticosteroids, with or without a leukotriene modifier, in children aged 6-11 years with symptomatic asthma.