Engineered metal based nanoparticles and innate immunity

Review

Claudia Petrarca¹, Emanuela Clemente², Valentina Amato¹, Paola Pedata³, Enrico Sabbioni¹, Giovanni Bernardini⁴⁵,Ivo Iavicoli⁶, Sara Cortese², Qiao Niu⁷, Takemi Otsuki⁸, Roberto Paganelli¹² and Mario Di Gioacchino^12*

Clinical and Molecular Allergy 2015, 13:13  doi:10.1186/s12948-015-0020-1

Abstract

Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used in a large number of applications including medical (for diagnostic and therapeutic purposes). Once inside the body, absorbed by inhalation, contact, ingestion and injection, MeNPs can translocate to tissues and, as any foreign substance, are likely to encounter the innate immunity system that represent a non-specific first line of defense against potential threats to the host. In this review, we will discuss the possible effects of MeNPs on various components of the innate immunity (both specific cells and barriers).

Food dependant exercise induced anaphylaxis a retrospective study from 2 allergy clinics in Colombo, Sri Lanka

Case report

Nilhan Rajiva de Silva^1*, Wasala Mudiyanselage Dhanushka Kumari Dasanayake¹, Chandima Karunatilleke¹ andGathsauri Neelika Malavige²

Allergy, Asthma & Clinical Immunology 2015, 11:22  doi:10.1186/s13223-015-0089-6

Abstract

The aetiology of anaphylaxis ranges from food, insect venom, drugs and various chemicals. Some individuals do not develop anaphylaxis with the offending agent unless ingestion is related temporally to physical exertion, namely food dependent exercise induced anaphylaxis (FDEIA).

Randomised, double-blind, placebo-controlled crossover study to investigate different dosing regimens of olodaterol delivered via Respimat® in patients with moderate to severe persistent asthma

Research

Kai-Michael Beeh^1*, Craig LaForce², Martina Gahlemann³, Arne Wenz⁴, Robert Toorawa⁵ and Matjaž Fležar⁶

Respiratory Research 2015, 16:87  doi:10.1186/s12931-015-0243-1

Abstract

Background

A Phase II, multicentre, randomised, double-blind, placebo-controlled, crossover trial comparing the 24-h forced expiratory volume in 1 s (FEV ₁ ) time profile after 3 weeks’ treatment with once-daily (QD) or twice-daily (BID) olodaterol (at the same total daily dose) versus placebo delivered via Respimat® in patients with moderate to severe asthma.

In Vitro Evaluation of Allergen Potencies of Commercial House Dust Mite Sublingual Immunotherapy Reagents

Original Article  Open Access

Allergy Asthma Immunol Res. 2015 Mar;7(2):124-129. English. Kyung Hee Park,1 Mina Son,1 Soo-Young Choi,1 Hey Jung Park,1 Jae-Hyun Lee,1 Kyoung Yong Jeong,1 Joo-Shil Lee,2 and Jung-Won Park1 Abstract Purpose The clinical efficacy of allergen-immunotherapy is known to be dose dependent. However, optimal maintenance dosage has not yet been determined for sublingual immunotherapy (SLIT). Furthermore, since companies adopt their own units for expression of allergenicity, the allergen concentrations of individual reagents cannot be compared easily. We sought to measure and compare the allergenicities of 3 commercially available house dust mite (HDM) SLIT regents and a subcutaneous immunotherapy reagent.

Activation of the Intrinsic Coagulation Pathway in Patients With Chronic Urticaria

Original Article  Open Access

Allergy Asthma Immunol Res. 2015 Sep;7(5):476-482. English. Published online May 22, 2015.  http://dx.doi.org/10.4168/aair.2015.7.5.476

Jung-Ah Kim,1, Sujeoung Kim,2,3, Ji-Eun Kim,1,4 Ja-Yoon Gu,1,4 Hyun Ju Yoo,1,4 Hye-Ryun Kang,2 and Hyun Kyung Kim1,4

Abstract

Purpose Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation assay (TGA) and the levels of individual coagulation factors.

Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care

Research

Sinisa Savic¹, Alexander Marsland², David McKay³, Michael R Ardern-Jones⁴, Tabi Leslie⁵⁶, Olivier Somenzi⁷, Laura Baldock⁸ and Clive Grattan^69*

Allergy, Asthma & Clinical Immunology 2015, 11:21  doi:10.1186/s13223-015-0088-7

Abstract

Background

Omalizumab is approved in the UK as add-on treatment for chronic spontaneous urticaria (CSU) in patients with inadequate response to H ₁ -antihistamines. Ciclosporin is an established but unlicensed 3rd line option for CSU. Two parallel retrospective observational studies were conducted to describe outcomes of treatment and adverse events with omalizumab or ciclosporin for CSU treatment.

Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs in Children and Adolescents: Cross-Intolerance Reactions

Blanca-López N1*, Cornejo-García JA2,3*, Plaza-Serón MC2, Doña I3, Torres-Jaén MJ3, Canto G1, Padilla-España L4, Kidon M5, Perkins JR2, Blanca M3 1Allergy Service, Infanta Leonor Hospital, Madrid, Spain 2Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain 3Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain 4Dermatology Service and Research Unit, Costa del Sol Hospital, Marbella, Spain 5Rheumatology, Immunology and Allergy Service, Department of Paediatric Medicine, Kandang Kerbau Children's Hospital, Singapore *Both authors contributed equally to the manuscript J Investig Allergol Clin Immunol 2015; Vol. 25(4): 259-269    Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are used worldwide and are responsible for several types of drug hypersensitivity reactions (DHRs) in all age groups. The 2 major groups of DHRs to NSAIDs are those induced by immunological mechanisms (selective reactions) and those where inflammatory mediators are released through activation of the prostaglandin-leukotriene pathway without specific immunological recognition (cross-intolerance). In the present review, we focus on cross-intolerance reactions, which are the most frequent DHRs and are becoming a topic of major interest in children and adolescents.

Self-reported adverse reactions and IgE sensitization to common foods in adults with asthma

Research

G. Rentzos^1*, L. Johanson², S. Sjölander⁴, E. Telemo³ and L. Ekerljung²

Clinical and Translational Allergy 2015, 5:25  doi:10.1186/s13601-015-0067-6

Abstract

Background

There is very few data available on the prevalence of food hypersensitivity among adults with asthma. The aim of this study was to explore the prevalence of self-reported adverse reactions and IgE sensitization to the different foods and to determine the spectrum and the prevalence of food-related gastrointestinal symptoms in adults with and with no asthma.