June 14, 2017

Angioedema suppressed by a combination of anti-histamine and leukotriene modifier

 
OPEN ACCESS
Rationale
Angioedema without co-existent urticaria is due to a limited number of causes, including hereditary and acquired C1 esterase inhibitor deficiency, drug-induced angioedema or idiopathic histaminergic or non-histaminergic angioedema. We describe a cohort of patients with recurrent angioedema whose clinical features and response to medications are distinct from the causes above.

June 12, 2017

Computational analysis of multimorbidity between asthma, eczema and rhinitis

OPEN ACCESS    PEER-REVIEWED
RESEARCH ARTICLE

Daniel Aguilar ,Mariona Pinart,Gerard H. Koppelman,Yvan Saeys,Martijn C. Nawijn,Dirkje S. Postma,Mübeccel Akdis,Charles Auffray,Stéphane Ballereau,Marta Benet,Judith García-Aymerich,Juan Ramón González,Stefano Guerra, Josep M. Antó

Abstract

Background
The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by identifying the proteins and cellular processes that are common to them.

Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy

Molecules and Cells in Allergy - Original Paper

Editor's Choice -- Free Access

Griffiths R.L.M. · El-Shanawany T. · Jolles S.R.A. · Selwood C. · Heaps A.G. · Carne E.M. · Williams P.E. 

Int Arch Allergy Immunol 2017;172:215-223

Background: Allergy is diagnosed from typical symptoms, and tests are performed to incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, and give immediate results. Laboratory tests (ImmunoCAP) for serum allergen-specific IgE antibodies are usually performed more selectively.

June 2, 2017

Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases

Eleonore Fröhlich1,2 and Richard Wahl1*
1Internal Medicine (Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry), University of Tuebingen, Tuebingen, Germany 2Center for Medical Research, Medical University Graz, Graz, Austria

Autoimmune diseases have a high prevalence in the population, and autoimmune thyroid disease (AITD) is one of the most common representatives. Thyroid autoantibodies are not only frequently detected in patients with AITD but also in subjects without manifest thyroid dysfunction. The high prevalence raises questions regarding a potential role in extra-thyroidal diseases. This review summarizes the etiology and mechanism of AITD and addresses prevalence of antibodies against thyroid peroxidase, thyroid-stimulating hormone receptor (TSHR), and anti-thyroglobulin and their action outside the thyroid.

June 1, 2017

Quality indicators for the acute and long-term management of anaphylaxis: a systematic review

Clinical and Translational Allergy
  • Sangeeta DhamiView ORCID ID profile,
  • Aadam Sheikh,
  • Antonella Muraro,
  • Graham Roberts,
  • Susanne Halken,
  • Monserat Fernandez Rivas,
  • Margitta Worm and
  • Aziz SheikhEmail author

Abstract
Background
The quality of acute and long-term anaphylaxis management is variable and this contributes to the poor outcomes experienced by many patients. Clinical practice guidelines have the potential to improve outcomes, but implementing guideline recommendations in routine practice is challenging. Quality indicators have the potential to support guideline implementation efforts.

May 22, 2017

Multicentre, non-interventional study to assess the profile of patients with uncontrolled rhinitis prescribed a novel formulation of azelastine hydrochloride and fluticasone propionate in a single spray in routine clinical practice in the UK

Respiratory medicine
Research

Glenis Scadding, David Price, Tariq El-Shanawany, Shahzada Ahmed, Jaydip Ray, Ravishankar Sargur, Nirmal Kumar

Abstract
Objective The aims of this study were (1) to characterise the type of patient prescribed MP-AzeFlu (Dymista, a novel formulation of azelastine hydrochloride, fluticasone propionate and excipients in a single spray) in real life in the UK and physicians' reasons for prescribing it and (2) to quantify the personal and societal burden of allergic rhinitis (AR) in the UK prior to MP-AzeFlu prescription.

May 20, 2017

IgE-mediated food allergies in children: prevalence, triggers, and management

REVIEW ARTICLE
Korean J Pediatr 2017 April;60(4) :99-105.
Published online 2017 April 15.  
Sooyoung Lee
Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea
Corresponding Author: Sooyoung Lee ,Tel: +82-31-219-5160, Fax: +82-31-219-5169, Email: jsjs87@ajou.ac.kr
ABSTRACT
Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea.

Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy

Drug Design, Development and Therapy. Volume 11

Angelo Massimiliano D’Erme,1,2 Marco Romanelli,2 Andrea Chiricozzi2

1Dermatology Unit, Livorno Hospital, Livorno, 2Dermatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy


Abstract: Atopic dermatitis (AD) is among the most common inflammatory skin diseases in children and adults in industrialized countries. Up to one-third of adults (probably a smaller proportion in childhood) suffer from moderate-to-severe AD, whose recommended treatment is usually based on systemic therapies. The currently available therapeutics are limited, and AD management becomes challenging in most cases.