Efficacy and safety of beclomethasone dipropionate nasal aerosol in children with perennial allergic rhinitis

Publication stage: In Press Corrected Proof

William E. Berger, MD, Robert L. Jacobs, MD, Niran J. Amar, MD, Sudeesh K. Tantry, PhD, Jiang Li, MS, Calvin J. Small, MD, MS

Open Access

DOI: http://dx.doi.org/10.1016/j.anai.2015.05.012

Article Info

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Abstract

Background

Beclomethasone dipropionate (BDP) nasal aerosol (non-aqueous) is approved for management of seasonal and perennial allergic rhinitis (PAR) in adolescents and adults.

Objective

To evaluate the efficacy and safety of BDP nasal aerosol at 80 μg/day in children with PAR.

Altered microRNA Expression Profiles of Extracellular Vesicles in Nasal Mucus From Patients With Allergic Rhinitis

	Original Article  Open Access
	Allergy Asthma Immunol Res. 2015 Sep;7(5):449-457. English. Published online Apr 14, 2015.  http://dx.doi.org/10.4168/aair.2015.7.5.449  Copyright © 2015 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease Geping Wu,1 Guanghai Yang,6 Ruxin Zhang,2 Guangyin Xu,3 Ling Zhang,4 Wu Wen,5 Jianbing Lu,1 Jianyong Liu,1 and Yan Yu1 Abstract Purpose Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. Exosomes or extracellular vesicles are nanosized vesicles of endosomal origin released from inflammatory and epithelial cells that have been implicated in allergic diseases. In this study, we characterized the microRNA (miRNA) content of exosomes in AR.

A survey of clinical features of allergic rhinitis in adults

• Med Sci Monit
• v.20; 2014
• PMC4228947

Med Sci Monit. 2014; 20: 2151–2156.

Published online 2014 Nov 4. doi:  10.12659/MSM.891206

PMCID: PMC4228947

Franco Frati,1,A Ilaria Dell’Albani,1,A Giovanni Passalacqua,2,B Sergio Bonini,3,B Oliviero Rossi,4,B Gianenrico Senna,5,B and Cristoforo Incorvaia6,E,F, on behalf of The Adult SURF Study Group

Author information ► Article notes ► Copyright and License information ►

Abstract

Background

Allergic rhinitis (AR) has high prevalence and substantial socio-economic burden.

Material/Methods

The study included 35 Italian Centers recruiting an overall number of 3383 adult patients with rhinitis (48% males, 52% females, mean age 29.1, range 18–45 years).

Approaches to the diagnosis and management of chronic urticaria in children

Korean J Pediatr > 2015 May;58(5) > Article

REVIEW ARTICLE

Korean J Pediatr 2015 May;58(5) :159-164. Published online 2015 May 15.

Sun Hee Choi1, Hey Sung Baek2 Share :    ABSTRACT Most guidelines for chronic urticaria (CU) in infants and children are based on limited pediatric evidence. Current evidence used to guide treatment in children is extrapolated from data focusing on older age groups. CU in children is a different and complex condition than that in adults. Furthermore, there is little published information regarding urticaria in Korean children. The aim of the present article is to review recent research on chronic childhood urticaria and improve the current understanding of its pathogenesis and management.

Asthma trajectories in early childhood: identifying modifiable factors

• PLoS One
• v.9(11); 2014
• PMC4224405

PLoS One. 2014; 9(11): e111922.

Published online 2014 Nov 7. doi:  10.1371/journal.pone.0111922

PMCID: PMC4224405

Lidia Panico,1,* Beth Stuart,2 Mel Bartley,3 and Yvonne Kelly3

Abstract

Background

There are conflicting views as to whether childhood wheezing represents several discreet entities or a single but variable disease. Classification has centered on phenotypes often derived using subjective criteria, small samples, and/or with little data for young children. This is particularly problematic as asthmatic features appear to be entrenched by age 6/7. In this paper we aim to: identify longitudinal trajectories of wheeze and other atopic symptoms in early childhood; characterize the resulting trajectories by the socio-economic background of children; and identify potentially modifiable processes in infancy correlated with these trajectories.

BMJ Open 2014;4:e006554 doi:10.1136/bmjopen-2014-006554

• Paediatrics

A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years

1. S Dick1, 
2. A Friend2, 
3. K Dynes2, 
4. F AlKandari2, 
5. E Doust3, 
6. H Cowie3, 
7. J G Ayres1,4, 
8. S W Turner2

Abstract

Objectives Childhood asthma is a complex condition where many environmental factors are implicated in causation. The aim of this study was to complete a systematic review of the literature describing associations between environmental exposures and the development of asthma in young children.

Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score.

Research

Alain Didier^1*, Hans-Jørgen Malling², Margitta Worm³, Friedrich Horak⁴ and Gordon L Sussman⁵

Clinical and Translational Allergy 2015, 5:12  doi:10.1186/s13601-015-0057-8

Published: 22 May 2015

Abstract

Background

The 300IR (index of reactivity) 5-grass pollen tablet has favorable short-term and sustained clinical efficacy in patients with grass pollen-induced allergic rhinoconjunctivitis (ARC). Here, we report maintenance of efficacy and safety over 2 years following treatment discontinuation.

Use of a basophil activation test as a complementary diagnostic tool in the diagnosis of severe peanut allergy in adults

Research

Georgios Rentzos^14*, Vanja Lundberg², Christina Lundqvist², Rui Rodrigues³, Jenny van Odijk¹, Anna-Carin Lundell²,Teet Pullerits¹ and Esbjörn Telemo²

Clinical and Translational Allergy 2015, 5:22  doi:10.1186/s13601-015-0064-9

Published: 11 June 2015

Abstract

Background

Diagnosis of severe peanut allergy is difficult and delays in making an accurate diagnosis may place the patient at risk. Adults with a history of anaphylaxis must strictly avoid any contact with peanuts or products that may contain traces of peanuts.