Reduced work/academic performance and quality of life in patients with allergic rhinitis and impact of allergen immunotherapy

Allergy, Asthma & Clinical Immunology201612:40 

DOI: 10.1186/s13223-016-0146-9

• A. Roger,
• E. Arcalá Campillo,
• M. C. Torres,
• C. Millan,
• I. Jáuregui,
• E. Mohedano,
• S. Liñan,
• P. Verdu,
• N. Rubira,
• M. Santaolalla,
• P. González,
• A. Orovitg and
• E. VillarrubiaEmail author

Abstract

Background

Allergic rhinitis (AR) is characterised by burdensome nasal and/or ocular symptoms. This inflammatory disease can be debilitating and thus result in considerable health-related and economic consequences.

Methods

In a cross-sectional study, adult subjects with AR (N = 683) completed three allergy-specific questionnaires that assessed the impact of AR on the work/academic performance, daily activities, health-related quality of life (HRQOL), and satisfaction with allergen immunotherapy (AIT).

Specific immunotherapy ameliorates ulcerative colitis

• Email author

Allergy, Asthma & Clinical Immunology201612:37DOI: 10.1186/s13223-016-0142-0

Min Cai,

Lu Zeng,

Lin-Jing Li,

Li-Hua Mo,

Rui-Di Xie,

Bai-Sui Feng,

Peng-Yuan Zheng,

Zhi-Gang Liu,

Zhan-Ju Liu

and

Ping-Chang Yang

Background

Hypersensitivity reaction to certain allergens plays a role in the pathogenesis of inflammatory bowel disease (IBD). This study aims to observe the effect of specific immunotherapy in a group of IBD patients.

Methods

Patients with both ulcerative colitis (UC) and food allergy were recruited into this study. Food allergy was diagnosed by skin prick test and serum specific IgE. The patients were treated with specific immunotherapy (SIT) and Clostridium butyricum (CB) capsules.

The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe

Int J Environ Res Public Health. 2016 Jan; 13(1): 93.

Published online 2015 Dec 30. doi:  10.3390/ijerph13010093

PMCID: PMC4730484

Signe Timm,1,* Morten Frydenberg,1 Christer Janson,2 Brittany Campbell,3 Bertil Forsberg,4 Thorarinn Gislason,5,6Mathias Holm,7 Rain Jogi,8 Ernst Omenaas,9 Torben Sigsgaard,1 Cecilie Svanes,9 and Vivi Schlünssen1,10

Abstract

The early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related to rural life mediate lower asthma prevalence in rural populations, and aimed to investigate an urban-rural gradient, assessed by place of upbringing, for asthma.

Pilot study: assessing the clinical diagnosis of allergy in atopic children using a microarray assay in addition to skin prick testing and serum specific IgE

RESEARCH

 

OPEN ACCESS

• Ru-Xin FoongEmail author,
• Graham Roberts,
• Adam Tobias Fox and
• George du Toit

Clinical and Molecular Allergy201614:8

DOI: 10.1186/s12948-016-0046-z

Abstract

Background

Children with atopic dermatitis (AD) are at risk of developing allergy. Alongside clinical history, testing modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) and recently, microarray assays. The aim of this pilot study was to assess current tests and the ISAC sIgE-112 system in the diagnosis of food and aeroallergen allergy.

Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist

David A. Khan, MDPress enter key for correspondence informationPress enter key to Email the author

Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, Texas

DOI: http://dx.doi.org/10.1016/j.anai.2016.05.013

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• Abstract

• Full Text

• References

Article Outline

1. Introduction
2. High Cytokine (Cytokine Release and Storm) Reactions
3. Common Acute Infusion Reactions
4. Hypersensitivity Reactions
5. Omalizumab
   1. Anaphylaxis to Omalizumab
   2. Proposed Mechanisms of Omalizumab Anaphylaxis
   3. Omalizumab Skin Testing
   4. Omalizumab Desensitization
   5. Omalizumab Serum Sickness-Like Reactions
6. Rituximab
   1. Immunodeficiency
   2. Serum Sickness-Like Reactions
   3. Anaphylaxis and Skin Testing
   4. Rapid Desensitization
7. Conclusions
8. References

Medical adherence to intranasal corticosteroids in adult patients

Brazilian Journal of Otorhinolaryngology

Available online 20 July 2016

In Press, Corrected Proof — Note to users

• Emre Ocak, 
• Baran Acar^, , 
• Deniz Kocaöz

doi:10.1016/j.bjorl.2016.06.007

Abstract

Introduction :The adherence to medical treatment in allergic rhinitis (AR) is poorly evaluated in clinical practice.

Objectives: To evaluate adherence to intranasal corticosteroids (ICS) in the treatment of allergic rhinitis AR patients.

Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis

DOI: 10.18632/oncotarget.10946

Ling-Zhi Xu1,*, Li-Tao Yang1,2,*, Shu-Qi Qiu1,2,*, Gui Yang1,2, Xiang-Qian Luo3, Bei-Ping Miao4, Xiao-Rui Geng1,2, Zhi-Qiang Liu1,2, Jun Liu5, Zhong Wen6, Shuai Wang1,2, Huan-Ping Zhang7, Jing Li8, Zhi-Gang Liu1, Hua-Bin Li3 and Ping-Chang Yang1

DOI: 10.18632/oncotarget.10946

ABSTRACT

The therapeutic efficacy of allergen specific immunotherapy (SIT) on allergic diseases is to be improved. Probiotics can regulate immune response. This study aims to promote the effect of SIT on allergic rhinitis (AR) by co-administration with Clostridium butyricum(Cb). In this study, patients with AR sensitized to mite allergens were enrolled to this study, and treated with SIT or/and Cb. The therapeutic efficacy was evaluated by the total nasal symptom scores (NSS), medication scores, serum specific IgE levels and T helper (Th)2 cytokine levels. The improvement of immune regulation in the AR patients was assessed by immunologic approaches.

Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis

Volume 396, Issue 11 (Nov 2015)

FREE ACCESS

Marina Le Lamer1 / Laurence Pellerin1, a / Marie Reynier1 / Laura Cau1 / Valérie Pendaries1, b / Corinne Leprince1 / Marie-Claire Méchin1 / Guy Serre1 / Carle Paul1, 2 / Michel Simon3

Abstract

The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2–3% of adults and often precedes the development of allergic rhinitis and asthma.