July 9, 2018

Dupilumab: A New Paradigm for the Treatment of Allergic Diseases

Sastre J1, Dávila I2
1Allergy Service, Fundación Jiménez Díaz, and Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
2Institute for Biomedical Research of Salamanca (IBSAL), Allergy Service, University Hospital of Salamanca, and Department of Biomedical and Diagnostics Sciences, Faculty of Medicine, Salamanca, Spain
Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the therapeutic options are often very limited. Treatment with systemic corticosteroids and immunosuppressants has adverse effects in the long term, and a significant proportion of patients remain refractory to therapy. In this context, the emerging biological drugs constitute a truly innovative therapeutic approach.

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Allergy Asthma Immunol Res. 2018 Jul; 10(4):354-362. English.
Published online February 26, 2018.  

So-Yeon Lee,1 Eun Lee,2 Yoon Mee Park,3 and Soo-Jong Hong1

Abstract

The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.



July 8, 2018

Association of Inadequately Controlled Disease and Disease Severity With Patient-Reported Disease Burden in Adults With Atopic Dermatitis

July 2, 2018

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Allergy Asthma Immunol Res. 2018 Jul;10(4):300-353. English.
https://doi.org/10.4168/aair.2018.10.4.300 
Lei Cheng,1,2, Jianjun Chen,3, Qingling Fu,4, Shaoheng He,5, Huabin Li,6, Zheng Liu,7, Guolin Tan,8, Zezhang Tao,9, Dehui Wang,6, Weiping Wen,4, Rui Xu,4, Yu Xu,9, Qintai Yang,10, Chonghua Zhang,6, Gehua Zhang,10, Ruxin Zhang,11, Yuan Zhang,12,13,14, Bing Zhou,14, Dongdong Zhu,15,Luquan Chen,16 Xinyan Cui,1 Yuqin Deng,9 Zhiqiang Guo,11 Zhenxiao Huang,14 Zizhen Huang,10Houyong Li,6 Jingyun Li,12 Wenting Li,10 Yanqing Li,6 Lin Xi,12 Hongfei Lou,14 Meiping Lu,1 Yuhui Ouyang,12 Wendan Shi,9 Xiaoyao Tao,4 Huiqin Tian,1 Chengshuo Wang,14 Min Wang,12 Nan Wang,7Xiangdong Wang,12,13,14 Hui Xie,17 Shaoqing Yu,18 Renwu Zhao,11 Ming Zheng,14 Han Zhou,1 Luping Zhu,19 and Luo Zhang12,13,14
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries.

Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study

BMJ 2018361 doi: https://doi.org/10.1136/bmj.k2400 Cite this as: BMJ 2018;361:k2400
  1. Kimberly G Blumenthal, assistant professor of medicine123,
  2. Na Lu, biostatistician1,
  3. Yuqing Zhang, professor of medicine13,
  4. Yu Li, research assistant12,
  5. Rochelle P Walensky, professor of medicine234,
  6. Hyon K Choi, professor of medicine13
    Author affiliations

Abstract

Objective To evaluate the relation between penicillin allergy and development of meticillin resistant Staphylococcus aureus (MRSA) and C difficile.

June 28, 2018

Heat-induced necrosis after bronchial thermoplasty: a new concern?

Open Access
Allergy, Asthma & Clinical Immunology
Allergy, Asthma & Clinical Immunology201814:25
Abstract
Background
Bronchial thermoplasty (BT) is an endoscopic procedure for the treatment of severe refractory asthma, based on the local airways delivery of radio-frequency at 65 °C. Several controlled clinical studies demonstrated the effectiveness of BT on clinical outcomes, particularly the reduction of asthma exacerbations. During procedure or shortly after, significant but transient respiratory adverse events have been reported.

June 19, 2018

Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children

Open Access
Allergy, Asthma & Clinical Immunology
  • Victoria Alejandra Gonzales-GonzálezEmail author,
  • Adolfo Martin Díaz,
  • Karla Fernández and
  • María Félix Rivera
Allergy, Asthma & Clinical Immunology201814:23
Abstract
Background
Food allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing countries. Honduras has no studies in pediatric patients.

Earlier smoking after waking and the risk of asthma: a cross-sectional study using NHANES data

Open Access
Open Peer Review
BMC Pulmonary Medicine
BMC Pulmonary Medicine201818:102
Abstract
Background
Recent research shows that nicotine dependence conveys additional health risks above and beyond smoking behavior. The current study examines whether smoking within 5 min of waking, an indicator of nicotine dependence, is independently associated with asthma outcomes.

Allergists on Social Media