February 6, 2016

Otitis Media with Effusion Executive Summary (Update)

Clinical Practice Guideline

Otitis Media with Effusion Executive Summary (Update)



The American Academy of Otolaryngology—Head and Neck Surgery Foundation has published a supplement to this issue of Otolaryngology—Head and Neck Surgery featuring the updated “Clinical Practice Guideline: Otitis Media with Effusion.” To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements.

February 5, 2016

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

Steven E. Boyden, Ph.D., Avanti Desai, M.S., Glenn Cruse, Ph.D., Michael L. Young, M.S.P.H., Hyejeong C. Bolan, M.S.N., Linda M. Scott, M.S.N., A. Robin Eisch, R.N., R. Daniel Long, B.S., B.A., Chyi-Chia R. Lee, M.D., Ph.D., Colleen L. Satorius, B.S., Andrew J. Pakstis, Ph.D., Ana Olivera, Ph.D., James C. Mullikin, Ph.D., Eliane Chouery, Ph.D., André Mégarbané, M.D., Ph.D., Myrna Medlej-Hashim, Ph.D., Kenneth K. Kidd, Ph.D., Daniel L. Kastner, M.D., Ph.D., Dean D. Metcalfe, M.D., and Hirsh D. Komarow, M.D.
February 3, 2016DOI: 10.1056/NEJMoa1500611

Patients with autosomal dominant vibratory urticaria have localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. We identified a previously unknown missense substitution in ADGRE2 (also known as EMR2), which was predicted to result in the replacement of cysteine with tyrosine at amino acid position 492 (p.C492Y), as the only nonsynonymous variant cosegregating with vibratory urticaria in two large kindreds. The ADGRE2 receptor undergoes autocatalytic cleavage, producing an extracellular subunit that noncovalently binds a transmembrane subunit. We showed that the variant probably destabilizes an autoinhibitory subunit interaction, sensitizing mast cells to IgE-independent vibration-induced degranulation. (Funded by the National Institutes of Health.)


FIGURE 1Inheritance and Clinical Features of Vibratory Urticaria.
FIGURE 2Vibration-Induced, ADGRE2-Enhanced Degranulation of Mast Cells from Patients.

February 4, 2016

Papain Induced Occupational Asthma with Kiwi and Fig Allergy

Nannan Jiang, Jia Yin and Liping Wen

Papain is a proteolytic enzyme which is widely used in food industry, pharmaceuticals, and cosmetics. Occupational and non-occupational papain allergies have previously been documented; however, there are limited publications about papain allergy with its relative fruit allergy. Here, we present a case of occupational, IgE-mediated papain allergy with kiwi fruit and fig fruit allergy.

February 1, 2016

One-year survey of paediatric anaphylaxis in an allergy department

Volume 47 n. 6/2015  November 2015

Â. Gaspar, N. Santos, S. Piedade, C. Santa-Marta, G. Pires, G. Sampaio, C. Arêde, L.M. Borrego, M. Morais-Almeida

Aim. To determine the frequency of anaphylaxis in an allergy outpatient department, allowing
a better understanding regarding aetiology, clinical manifestations and management, in children and adolescents. Methods. From among 3646 patients up to 18 years old observed during one-year period, we included those with history of anaphylaxis reported by allergists.

January 29, 2016

Antibiotic-induced immediate type hypersensitivity is a risk factor for positive allergy skin tests for neuromuscular blocking agents

Skin tests for neuromuscular blocking agents (NMBAs) are not currently recommended for the general population undergoing general anaesthesia. In a previous study we have reported a high incidence of positive allergy tests for NMBAs in patients with a positive history of non-anaesthetic drug allergy, a larger prospective study being needed to confirm those preliminary results. The objective of this study was to compare the skin tests results for patients with a positive history of antibiotic-induced immediate type hypersensitivity reactions to those of controls without drug allergies.

Drugs as important factors causing allergies

Logo of pdiaLink to Publisher's site
Postepy Dermatol Alergol. 2015 Oct; 32(5): 388–392.
Published online 2015 Oct 29. doi:  10.5114/pdia.2014.44021
PMCID: PMC4692812
Medications can cause many adverse reactions, both non-immunologic and immunologic ones. Allergies can take many forms, allergic reactions include all types of reactions according to Gell and Coombs. Typically, allergic reactions to drugs are manifested by skin lesions such as maculopapular rash or urticaria and life-threatening systemic reactions such as anaphylaxis.

January 28, 2016

Circulating Dendritic Cells, Farm Exposure and Asthma at Early Age

Scandinavian Journal of Immunology
  1. H. Kääriö1,*
  2. J. K. Nieminen2
  3. A. M. Karvonen3
  4. K. Huttunen1
  5. P. C. Schröder4,
  6. O. Vaarala5
  7. E. von Mutius4
  8. P.I. Pfefferle6,
  9. B. Schaub4
  10. J. Pekkanen3,7
  11. M.-R. Hirvonen1,3 and
  12. M. Roponen1

      1. Abstract
        Farm environment has been shown to protect from childhood asthma. Underlying immunological mechanisms are not clear yet, including the role of dendritic cells (DCs). The aim was to explore whether asthma and farm exposures are associated with the proportions and functional properties of DCs from 4.5-year-old children in a subgroup of the Finnish PASTURE birth cohort study.

January 26, 2016

Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial

, and .
Southampton (UK): NIHR Journals Library.
The study found no clear benefit of intermittent montelukast in young children with wheeze. Further research is need to determine if a variant allele of ALOX5 identifies individuals who are more responsive to montelukast.
The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5) gene promoter

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