October 26, 2016

Urine metabolome profiling of immune-mediated inflammatory diseases

BMC Medicine


  • Arnald Alonso,
  • Antonio JuliàEmail authorView ORCID ID profile,
  • Maria Vinaixa,
  • Eugeni Domènech,
  • Antonio Fernández-Nebro,
  • Juan D. Cañete,
  • Carlos Ferrándiz,
  • Jesús Tornero,
  • Javier P. Gisbert,
  • Pilar Nos,
  • Ana Gutiérrez Casbas,
  • Lluís Puig,
  • Isidoro González-Álvaro,
  • José A. Pinto-Tasende,
  • Ricardo Blanco,
  • Miguel A. Rodríguez,
  • Antoni Beltran,
  • Xavier Correig,
  • Sara MarsalEmail author and
  • for the IMID Consortium
Immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent diseases where disease diagnostic and activity monitoring is highly challenging. The determination of the metabolite profiles of biological samples is becoming a powerful approach to identify new biomarkers of clinical utility. In order to identify new metabolite biomarkers of diagnosis and disease activity, we have performed the first large-scale profiling of the urine metabolome of the six most prevalent IMIDs: rheumatoid arthritis, psoriatic arthritis, psoriasis, systemic lupus erythematosus, Crohn’s disease, and ulcerative colitis.

Applicability of predictive toxicology methods for monoclonal antibody therapeutics: status Quo and scope

Open Access  Review Article 
  • Arathi Kizhedath
  • Simon Wilkinson
  • Jarka Glassey
Biopharmaceuticals, monoclonal antibody (mAb)-based therapeutics in particular, have positively impacted millions of lives. MAbs and related therapeutics are highly desirable from a biopharmaceutical perspective as they are highly target specific and well tolerated within the human system. Nevertheless, several mAbs have been discontinued or withdrawn based either on their inability to demonstrate efficacy and/or due to adverse effects.

October 25, 2016

Mast cell desensitization inhibits calcium flux and aberrantly remodels actin

J Clin Invest. 2016. doi:10.1172/JCI87492.
View: Text | PDF

First published September 26, 2016 - 
Rush desensitization (DS) is a widely used and effective clinical strategy for the rapid inhibition of IgE-mediated anaphylactic responses. However, the cellular targets and underlying mechanisms behind this process remain unclear. Recent studies have implicated mast cells (MCs) as the primary target cells for DS. Here, we developed a murine model of passive anaphylaxis with demonstrated MC involvement and an in vitro assay to evaluate the effect of DS on MCs.

October 24, 2016

Data on the oral CRTh2 antagonist QAW039 (fevipiprant) in patients with uncontrolled allergic asthma

Logo of dibGuide for AuthorsAboutExplore this JournalData in Brief
. 2016 Dec; 9: 199–205.
Published online 2016 Aug 29. doi:  10.1016/j.dib.2016.08.039
PMCID: PMC5021787
This article contains data on clinical endpoints (Peak Flow Expiratory Rate, fractional exhaled nitric oxide and total IgE serum levels) and plasma pharmacokinetic parameters concerning the use of the oral CRTh2 antagonist QAW039 (fevipiprant) in mild to moderate asthma patients.

October 17, 2016

Asthma-related deaths

  • Gennaro D’AmatoEmail author,
  • Carolina Vitale,
  • Antonio Molino,
  • Anna Stanziola,
  • Alessandro Sanduzzi,
  • Alessandro Vatrella,
  • Mauro Mormile,
  • Maurizia Lanza,
  • Giovanna Calabrese,
  • Leonardo Antonicelli and
  • Maria D’Amato
Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurely each year from asthma. Trends of asthma mortality rates vary very widely across countries, age and ethnic groups. Several risk factors have been associated with asthma mortality, including a history of near-fatal asthma requiring intubation and mechanical ventilation, hospitalization or emergency care visit for asthma in the past year, currently using or having recently stopped using oral corticosteroids (a marker of event severity), not currently using inhaled corticosteroids, a history of psychiatric disease or psychosocial problems, poor adherence with asthma medications and/or poor adherence with (or lack of) a written asthma action plan, food allergy in a patient with asthma.

Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

Respiratory Research


  • Thomas SouthworthEmail author,
  • Jonathan Plumb,
  • Vandana Gupta,
  • James Pearson,
  • Isabel Ramis,
  • Martin D. Lehner,
  • Montserrat Miralpeix and
  • Dave Singh
Phosphatidylinositol 3-kinase delta (PI3Kδ) and Janus-activated kinases (JAK) are both novel anti-inflammatory targets in asthma that affect lymphocyte activation. We have investigated the anti-inflammatory effects of PI3Kδ and JAK inhibition on cytokine release from asthma bronchoalveolar lavage (BAL) cells and T-cell activation, and measured lung PI3Kδ and JAK signalling pathway expression.

Glial Cells are Involved in Itch Processing

Acta Derm Venereol 2016; XX: XX–XX.
Hjalte H. Andersen, Lars Arendt-Nielsen and Parisa Gazerani*
SMI®, Department of Health Science and Technology, School of Medicine, Aalborg University, Denmark
Recent discoveries in itch neurophysiology include itch-selective neuronal pathways, the clinically relevant non-histaminergic pathway, and elucidation of the notable similarities and differences between itch and pain. Potential involvement of glial cells in itch processing and the possibility of glial modulation of chronic itch have recently been identified, similarly to the established glial modulation of pain processing.

October 15, 2016

Antibodies and Superantibodies in Chronic Rhinosinusitis with Nasal Polyps

Article in Press
Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with local immunoglobulin hyperproduction and the presence of IgE antibodies against Staphylococcus aureus enterotoxins (SAEs). Aspirin-exacerbated respiratory disease (AERD) is a severe form of CRSwNP in which nearly all patients express anti-SAEs.

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