March 28, 2015

World Allergy Week 2015 - Slide Set Presentation

March 19, 2015

Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance


PLoS Genet. 2015 Mar; 11(3): e1005076.
Published online 2015 Mar 10. doi:  10.1371/journal.pgen.1005076
PMCID: PMC4355615

Abstract

Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or due to maternal effects reflecting the maternal genome's influence on the child during prenatal development.

March 18, 2015

SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms

Abstract

Background

House dust mite (HDM) allergy is associated with persistent allergic rhinitis (AR) and allergic asthma.

Objective

To investigate the efficacy and safety of a SQ HDM sublingually administered immunotherapy tablet (ALK, Hørsholm, Denmark) in adults and adolescents with HDM respiratory allergic disease and report the AR results.

Methods

Six hundred four subjects at least 14 years old with HDM AR and mild to moderate HDM allergic asthma were randomized 1:1:1:1 to double-blinded daily treatment with 1, 3, 6 SQ-HDM or placebo. End-of-treatment rhinoconjunctivitis symptoms and medication score were predefined extrapulmonary end points. A subgroup analysis was conducted post hoc in subjects with a total combined rhinitis score (TCRS) > 0 (ie, with AR symptoms and/or AR medication use during the 4-week baseline period). The subgroup was comprised of 498 subjects (82%).

Results

In the subgroup, the absolute difference in end-of-treatment TCRS between 6 SQ-HDM and placebo was −0.78 (95% confidence interval −1.47 to −0.07, relative difference 28.8%, P = .0357). Furthermore, a significant difference was found for the total score of the Rhinitis Quality of Life Questionnaire with Standardized Activities RQLQ(S) and for the individual domains: activities, sleep, non-nose and non-eye symptoms, and nasal symptoms. For the TCRS and Rhinitis Quality of Life Questionnaire score, a dose response was seen, with numerically lower, nonsignificant differences for 1 and 3 SQ-HDM. The predefined analysis for the entire trial population showed no statistically significant difference between the placebo and actively treated groups. No safety concerns were observed.

Conclusion

Efficacy in mild to severe AR of 6 SQ-HDM compared with placebo was demonstrated by statistically significant improvements in TCRS and Rhinitis Quality of Life Questionnaire score in subjects with AR present at baseline. The treatment was well tolerated.

Trial Registration

EudraCT, no 2006-001795-20; ClinicalTrials.gov, identifier NCT00389363.
Disclosure: Dr Mosbech previously received funding from ALK. Dr Klimek received grants, honoraria, and consulting fees from ALK (Hoersholm Denmark). Mr Ljørring owns ALK stock. L.B. and C.L. are employees of ALK. The remaining authors declared no conflicts of interest.
Funding: The trial was sponsored by ALK (Hørsholm, Denmark) who assumes overall responsibility for the trial and was involved in the trial design and conduct.

March 10, 2015

Effect of breastfeeding on lung function in asthmatic children

    Hwan Soo Kim, M.D.1; Yoon Hee Kim, M.D.2; Min Jung Kim, M.D.2; Hee Seon Lee, M.D.2; Yoon Ki Han, M.D.2; Kyung Won Kim, M.D., Ph.D.2; Myung Hyun Sohn, M.D., Ph.D.2; Kyu-Earn Kim, M.D., Ph.D.2
    From the 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea, and 2Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
Address correspondence to Kyung Won Kim, M.D., Ph.D., Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail address: kwkim@yuhs.ac
Effect of breastfeeding on the protective effect on asthma has been studied extensively but remains controversial. Studies regarding the effect of breastfeeding on lung function have also been conflicting. The aim of this study was to determine the influence of breastfeeding on lung function in asthmatic children. We included 555 patients who visited Severance Children's Hospital Allergy Clinic with asthma.

A practical approach to vitamin and mineral supplementation in food allergic children

Research

Open Access

Rosan Meyer1*Claire De Koker2Robert Dziubak1Ana-Kristina Skrapac2Heather Godwin1Kate Reeve1Adriana Chebar-Lozinsky1 and Neil Shah13Clinical and Translational Allergy 2015, 5:11  doi:10.1186/s13601-015-0054-y

Abstract (provisional)

Background The management of food allergy in children requires elimination of the offending allergens, which significantly contribute to micronutrient intake. Vitamin and mineral supplementation are commonly suggested as part of dietary management.

March 4, 2015

Chronic urticaria in adults: state-of-the-art in the new millennium

Abstract
Chronic urticaria has been explored in several investigative aspects in the new millennium, either as to its pathogenesis, its stand as an autoimmune or auto-reactive disease, the correlation with HLA-linked genetic factors, especially with class II or its interrelation with the coagulation and fibrinolysis systems.

Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines

Research

Open Access

Christoffer V NissenCarsten Bindslev-Jensen and Charlotte G Mortz*

Abstract (provisional)
Background Non-steroidal anti-inflammatory drugs (NSAIDs) are reported to be the second most common cause of drug hypersensitivity. In 2011, experts from the EAACI/ENDA group and GA2LEN proposed a new classification system for NSAID hypersensitivity. The aim of this study was to classify a patient cohort with a history of NSAID hypersensitivity according to this system. 
Methods Patients with a clinical history of NSAID hypersensitivity referred to the Allergy Centre, Odense University Hospital between 2002 and 2011 and evaluated with oral provocation tests (OPTs) were included in the study. Medical records were retrospectively investigated with respect to the culprit NSAID(s), underlying diseases and symptoms at the primary reaction and during oral provocation tests (OPTs). Data was supplemented with a questionnaire. Classification according to EAACI guideline was based on these findings. 
Results In total 149 patients were included. Of those, 39 patients (26.2%) had a positive OPT. Twenty-nine patients were classified as cross-reactive responders and 9 patients as single NSAID responders after positive OPTs with the culprit NSAID, but not to acetylsalicylic acid. All single NSAID responders reacted to non-pyrazolone drugs. Only one patient could not be classified according to the EAACI/ENDA system. An overlap between respiratory and cutaneous symptoms was found in 15/39 (38%) of patients. 
Conclusions All but one of our patients could be classified according to the EAACI classification system. Overlaps between different classes may occur much more commonly than expected.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based Antihepatitis C Virus Therapy

Case Reports in Immunology
Volume 2015 (2015), Article ID 816424, 5 pages
http://dx.doi.org/10.1155/2015/816424
Case Report
Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Lagro Brambilla 3, 50134 Florence, Italy
Received 26 September 2014; Revised 9 January 2015; Accepted 20 January 2015
Academic Editor: Lenin Pavón
Copyright © 2015 Teresa Urraro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Mixed cryoglobulinemia (MC) is an autoimmune/B-cell lymphoproliferative disorder associated with Hepatitis C Virus (HCV) infection, manifesting as a systemic vasculitis.

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