February 27, 2015

H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis


Abstract

BACKGROUND:
Allergic rhinitis (AR) is one of the most common allergic diseases. The results of recent studies of HLA-DRB1 suggest that HLA-DRB1 plays an important role in allergic disease.

February 26, 2015

Evaluation of patients’ expectations and benefits in the treatment of allergic rhinitis with a new tool: the patient benefit index – the benefica study

Research

Open Access

Pascal Demoly1*Michel Aubier234Frédéric de Blay5François Wessel6Pierre Clerson7 and Pascal Maigret8

Abstract (provisional)
Background Symptoms of allergic rhinitis (AR) have a detrimental effect on quality of life. The AR-Patient Benefit Index (AR-PBI), a specific self-assessment tool has been developed to assess treatment-related benefit in two separate sections: the Patient Needs Questionnaire (PNQ) which explores the patient’s expectations before treatment and the Patient Benefit Questionnaire (PBQ) which evaluates treatment benefit. For the PNQ, three dimensions summarized patients’ expectations: symptoms, social life and emotional state, thus covering a larger field than symptomatic relief.

Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients

Research

Open Access

Thuy-My Le1*Els van Hoffen110Ischa Kummeling12James Potts2Barbara K Ballmer-Weber3Carla AFM Bruijnzeel-Koomen1Ans FM Lebens1Jonas Lidholm4Titia M Lindner1Alan Mackie5EN Clare Mills6Ronald van Ree7Stefan Vieths8Montserrat Fernández-Rivas9Peter G Burney2 and André C Knulst1


Abstract (provisional)
Background It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.
Objective To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.

February 25, 2015

Evaluation of a web-based asthma self-management system: a randomised controlled pilot trial

Research article

Open Access

John M Wiecha1*William G Adams2Denis Rybin3Maria Rizzodepaoli4Jeremy Keller5and Jayanti M Clay6

Abstract (provisional)
Background Asthma is the most common chronic condition of childhood and disproportionately affects inner-city minority children. Low rates of asthma preventer medication adherence is a major contributor to poor asthma control in these patients.

A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroids

Research

Open Access

Christian Vogelberg1*Petra Moroni-Zentgraf2Migle Leonaviciute-Klimantaviciene3Ralf Sigmund4Eckard Hamelmann5Michael Engel2 and Stanley Szefler6

Abstract
Background
A considerable number of children with asthma remain symptomatic despite treatment with inhaled corticosteroids, resulting in significant morbidity, reduced quality of life, increased healthcare costs and lost school days.

February 24, 2015

Insights and advances in chronic urticaria: a Canadian perspective

Review

Open Access

Gordon Sussman1*Jacques Hébert2Wayne Gulliver3Charles Lynde1Susan Waserman4Amin Kanani5Moshe Ben-Shoshan6Spencer Horemans1Carly Barron1,Stephen Betschel1William H Yang7Jan Dutz5Neil Shear1Gina Lacuesta8Peter Vadas1Kenneth Kobayashi7Hermenio Lima4 and F Estelle R Simons9

Abstract

In the past few years there have been significant advances which have changed the face of chronic urticaria. In this review, we aim to update physicians about clinically relevant advances in the classification, diagnosis and management of chronic urticaria that have occurred in recent years.

Effects of Nasal Corticosteroids on Boosts of Systemic Allergen-Specific IgE Production Induced by Nasal Allergen Exposure


OPEN ACCESS
PEER-REVIEWED
RESEARCH ARTICLE

Cornelia Egger, Christian Lupinek, Robin Ristl, Patrick Lemell, Friedrich Horak, Petra Zieglmayer, Susanne Spitzauer, Rudolf Valenta, Verena Niederberger

Published: February 23, 2015

Abstract

Background

Allergen exposure via the respiratory tract and in particular via the nasal mucosa boosts systemic allergen-specific IgE production. Intranasal corticosteroids (INCS) represent a first line treatment of allergic rhinitis but their effects on this boost of allergen-specific IgE production are unclear.

February 23, 2015

Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study

Research

Open Access

Daniela Kuguimoto Andaku1Vânia D’Almeida14*Gláucia Carneiro2Sônia Hix13Sergio Tufik1 and Sônia Maria Togeiro1

Abstract
Background
The simultaneous occurrence of metabolic syndrome and excessive daytime sleepiness are very common in obstructive sleep apnea (OSA) patients. Both conditions, if present in OSA, have been reported to be associated with inflammation and disruption of oxidative stress balance that impair the cardiovascular system. To verify the impact of daytime sleepiness on inflammatory and oxidative stress markers, we evaluated OSA patients without significant metabolic disturbance.

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