September 26, 2016

Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

  1. M. A. Ghannoumb
+Author Affiliations
  1. aInserm U995-Team 2, Université Lille 2, Faculté de Médecine H. Warembourg, Pôle Recherche, CHRU de Lille, Lille, France
  2. bCenter for Medical Mycology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
  3. cEpimad Registry, Epidemiology Unit and LIRIC Inserm 995, Lille University and Hospital, Lille, France
  4. dDepartment of Gastroenterology, University Hospital Leuven, Leuven, Belgium
  5. eDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  6. fImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  7. gDepartment of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  8. hEM Core Facility, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
  1. Address correspondence to B. Sendid, bsendid@univ-lille2.fr, or M. A. Ghannoum,Mahmoud.Ghannoum@case.edu.
  1. G.H. and P.K.M. contributed equally to the study.
  2. Editor Robert A. Bonomo, Louis Stokes Veterans Affairs Medical Center
ABSTRACT
Crohn’s disease (CD) results from a complex interplay between host genetic factors and endogenous microbial communities. In the current study, we used Ion Torrent sequencing to characterize the gut bacterial microbiota (bacteriome) and fungal community (mycobiome) in patients with CD and their nondiseased first-degree relatives (NCDR) in 9 familial clusters living in northern France-Belgium and in healthy individuals from 4 families living in the same area (non-CD unrelated [NCDU]).

September 25, 2016

Clinical Relevance of IgE to Profilin and/or Polcalcin in Pollen-Sensitized Patients

Editor's Choice -- Free Access

(DOI:10.1159/000444279)

San Nicoló M. · Braun T. · Eder K. · Berghaus A. · Gröger M. 
Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University Munich, Munich, Germany

Abstract
Background: Component-resolved diagnostics is gaining importance in allergy diagnostics. Allergen extracts contain components with different rates of prevalence and clinical relevance, which can be subdivided at molecular level into major and minor allergens.

Setting Occupational Exposure Limits for Chemical Allergens—Understanding the Challenges

. 2015 Nov 25; 12(sup1): S82–S98.
Published online 2015 Nov 19. doi:  10.1080/15459624.2015.1072277
PMCID: PMC4685595
NIHMSID: NIHMS746362
Abstract
Chemical allergens represent a significant health burden in the workplace. Exposures to such chemicals can cause the onset of a diverse group of adverse health effects triggered by immune-mediated responses. Common responses associated with workplace exposures to low molecular weight (LMW) chemical allergens range from allergic contact dermatitis to life-threatening cases of asthma.

Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®


Abstract
Introduction
A number of safety signals—complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)—have emerged with human papillomavirus (HPV) vaccines, which share a similar pattern of symptomatology. Previous signal evaluations and epidemiological studies have largely relied on traditional methodologies and signals have been considered individually.

September 21, 2016

Active treatment for food allergy

Abstract
Food allergy has grown in rapidly in prevalence, currently affecting 5% of adults and 8% of children. Management strategy is currently limited to 1) food avoidance and 2) carrying and using rescue intramuscular epinephrine/adrenaline and oral antihistamines in the case of accidental ingestion; there is no FDA approved treatment. Recently, oral, sublingual and epicutaneous immunotherapy have been developed as active treatment of food allergy, though none have completed phase 3 study.

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