May 24, 2015

Antibiotics in the first week of life is a risk factor for allergic rhinitis at school age

Heredity as well as external factors influences the development of allergic rhinitis. The aim of this study was to analyse early risk factors and protective factors for allergic rhinitis at school age.

Type-2 innate lymphoid cells in human allergic disease

Logo of lwwopenLippincott Williams & WilkinsThis article
Current Opinion in Allergy and Clinical Immunology
Purpose of review
Recent decades have seen allergic diseases become endemic in a number of developed countries. Understanding the inflammatory processes that dictate these allergic responses is therefore important.

Physical training for asthma

Sao Paulo Med. J. vol.132 no.3 São Paulo  2014 


Kristin V. Carson, Madhu G. Chandratilleke, Joanna Picot, Malcom P. Brinn, Adrian J. Esterman A., Brian J. Smith
People with asthma may show less tolerance to exercise due to worsening asthma symptoms during exercise or other reasons such as deconditioning as a consequence of inactivity. Some may restrict activities as per medical advice or family influence and this might result in reduced physical fitness. Physical training programs aim to improve physical fitness, neuromuscular coordination and self confidence. Subjectively, many people with asthma report that they are symptomatically better when fit, but results from trials have varied and have been difficult to compare because of different designs and training protocols. Also, as exercise can induce asthma, the safety of exercise programmes needs to be considered.

May 23, 2015

Prescribing of long-acting beta-2-agonists/inhaled corticosteroids after the SMART trial

Research article

Marietta Rottenkolber1*Rainald Fischer2Luisa Ibáñez34Joan Fortuny5Robert Reynolds6Justyna Amelio7Roman Gerlach8Martin Tauscher8Petra Thürmann109Joerg Hasford1 and Sven Schmiedl109

After the SMART trial evaluating the safety of salmeterol (long-acting beta-2-agonist (LABA)) in asthma patients, regulatory actions were taken to promote a guideline-adherent prescribing of LABA only to patients receiving inhaled corticosteroids (ICS). We aim to analyse LABA- and ICS-related prescription patterns after the SMART trial in Germany.

The effect of a new communication template on anticipated willingness to initiate or resume allergen immunotherapy: an internet-based patient survey

Moises A. Calderon1*, Linda Cox2, Thomas B. Casale3, Ralph Mösges4, Oliver Pfaar56, Hans-Jørgen Malling7, Joaquin Sastre8, Musa Khaitov9 and Pascal Demoly1011
Abstract (provisional)
Background A patient’s knowledge of his/her allergic condition and treatment is a key factor in adherence and effectiveness. 
Methods To assess patients’ understanding of allergy and acceptance of allergen immunotherapy on the basis of (i) information given by their physician at the time of prescription and (ii) a new communication template viewed some months later, we performed an Internet-based survey of patient panels in France, Germany, Spain, the USA and Russia.

May 20, 2015

Nitration of β-Lactoglobulin but Not of Ovomucoid Enhances Anaphylactic Responses in Food Allergic Mice.


We revealed in previous studies that nitration of food proteins reduces the risk of de novo sensitization in a murine food allergy model. In contrast, in situations with preformed specific IgE antibodies, in vitro experiments suggested an increased capacity of effector cell activation by nitrated food proteins.
The aim of this study was to investigate the influence of protein nitration on the effector phase of food allergy.

Mites and other indoor allergens — from exposure to sensitization and treatment

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  • Abstract:
    House dust mites, cats and dogs are amongst the most frequent sources of indoor allergens in Europe. The fact that the allergens of house dust mites cause allergic disease through inhalation of house dust was discovered in 1964. The diagnosis of mite allergy is regularly complicated by its often nonspecific symptoms, which frequently develop insidiously and by no means always include attacks of paroxysmal sneezing and itching.

    Effect of chemical modifications on allergenic potency of peanut proteins

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