August 28, 2015

Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist’s View

Annals of Dermatology 2015 ; 27(4): 355~363 
Dong-Ho Nahm
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The current standard medical therapy for atopic dermatitis (AD) mainly focuses on symptomatic relief by controlling skin inflammation with topical corticosteroids and/or topical calcineurin inhibitors. However, the clinical efficacy of pharmacological therapy is often disappointing to both patients and physicians. The terminology of AD contains a historical meaning of eczematous dermatitis caused by hypersensitivity reaction to environmental inhalant or food allergen.

August 26, 2015

Central obesity and other factors associated with uncontrolled asthma in women

Research

Highly Accessed

Open AccessAlbertina Varandas Capelo1*Vania Matos de Fonseca2Maria Virgínia Marques Peixoto2Sonia Regina de Carvalho1and Larissa Garcia Guerino1
Abstract
Background
Asthma remains an uncontrolled disease. The Comorbidities, particularly obesity, and several other factors have been identified as being individually associated with asthma control, and these factors vary among different countries and between sexes. Studies have suggested that the harmful effects of these factors are greatest among women. The aim of the present study was to identify associated factors with uncontrolled asthma in women at the outpatient clinic of a Federal University Hospital in Rio de Janeiro, Brazil.

Accidental exposures to peanut in a large cohort of Canadian children with peanut allergy

Brief communication

Open AccessHighly Accessed

Sabrine Cherkaoui1Moshe Ben-Shoshan2Reza Alizadehfar3Yuka Asai4Edmond Chan5Stephen Cheuk6Greg Shand7Yvan St-Pierre8Laurie Harada9Mary Allen10 and Ann Clarke11*

Abstract
Background
We previously estimated that the annual rate of accidental exposure to peanut in 1411 children with peanut allergy, followed for 2227 patient-years, was 11.9% (95% CI, 10.6, 13.5). This cohort has increased to 1941 children, contributing 4589 patient-years, and we determined the annual incidence of accidental exposure, described the severity, management, location, and identified associated factors.

Examination of Patients Suspected as Having Hypersensitivity to Iodinated Contrast Media with Leukocyte Migration Test

Biological and Pharmaceutical Bulletin
Vol. 37 (2014) No. 11 p. 1750-1757

Language: 

http://doi.org/10.1248/bpb.b14-00346
Regular Articles
In vivo tests may be used for the diagnosis of allergy to iodinated contrast media (ICM); however, the tests do not provide definitive diagnosis and are associated with risks for patients. Diagnoses based on in vitro tests are limited, and there are almost no relevant studies. Herein, the authors examined involvement of allergic reaction from a multilateral standpoint in 39 patients suspected of having ICM allergies using leukocyte migration test (LMT). The positive rate of LMT was 44%.

Racial differences in eosinophilic gastrointestinal disorders among Caucasian and Asian

Abstract

Background

Although there is an increasing number of eosinophilic gastrointestinal disorders (EGID) cases including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), being reported globally, no systematic reviews have been conducted to elucidate the racial differences in these disorders. We aimed to show the racial differences, especially among Caucasians and Asians, in the risk of EoE and EGE.

August 24, 2015

Anaphylaxis Preparedness among Preschool Staff before and after an Educational Intervention

Journal of Allergy
Volume 2015 (2015), Article ID 231862, 5 pages
http://dx.doi.org/10.1155/2015/231862
Research Article
1Department of Emergency Medicine, University of California, San Francisco, San Francisco, CA, USA
2Department of Emergency Medicine, Mayo Clinic, Rochester, MN, USA
3Department of Emergency Medicine, Mayo Clinic Health System in Mankato, Mankato, MN, USA
Abstract
Introduction. Children with severe food allergies may spend many hours in the preschool setting. Little is known about anaphylaxis recognition and management preparedness among preschool staff. The objective of this study was to assess anaphylaxis preparedness among preschool staff. Methods. Anonymous questionnaires were administered before and after a 40-minute educational seminar on anaphylaxis recognition and management.

Gene expression profiles in chronic idiopathic (spontaneous) urticaria

Abstract:
Background: The pathophysiology of chronic idiopathic (spontaneous) urticaria (CIU) is poorly understood. 

Objective: We hypothesized that a study of gene expression in active lesions from patients with CIU would uncover unexpected associations. 

August 22, 2015

Integrating microbial and host transcriptomics to characterize asthma-associated microbial communities

Research article

Open Access

Eduardo Castro-Nallar15*Ying Shen2Robert J. Freishtat3Marcos Pérez-Losada134Solaiappan Manimaran2Gang Liu2W. Evan Johnson2 and Keith A. Crandall1*

Abstract
Background
The relationships between infections in early life and asthma are not completely understood. Likewise, the clinical relevance of microbial communities present in the respiratory tract is only partially known. A number of microbiome studies analyzing respiratory tract samples have found increased proportions of gamma-Proteobacteria including Haemophilus influenzaeMoraxella catarrhalis, and Firmicutes such as Streptococcus pneumoniae. The aim of this study was to present a new approach that combines RNA microbial identification with host gene expression to characterize and validate metagenomic taxonomic profiling in individuals with asthma.

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