A Case of Serum Sickness-Like Reaction and Anaphylaxis - Induced Simultaneously by Rifampin

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	Allergy Asthma Immunol Res. 2014 Mar;6(2):183-185. English. Published online 2013 September 27.  http://dx.doi.org/10.4168/aair.2014.6.2.183  Copyright © 2014 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease Dong-Hyun Kim, Young Hwan Choi, Hyoung Sang Kim, Ji Eun Yu and Young-Il Koh Department of Allergy, Asthma, and Clinical Immunology, Chonnam National University Medical School, Gwangju, Korea. Correspondence to: Young-Il Koh, MD, Department of Allergy, Asthma, and Clinical Immunology, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 501-746, Korea. Tel: +82-62-220-6580; Fax: +82-62-225-8578; Email: yikoh@chonnam.ac.kr  Received January 28, 2013; Revised March 18, 2013; Accepted April 15, 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Rifampin is commonly used as a first-line anti-tuberculosis drug, but it can induce a serum sickness-like reaction or anaphylaxis. However, it is possible for 1 drug antigen to induce 2 or more simultaneous immunologic reactions. Here, we report a case of a serum-sickness-like reaction and anaphylaxis induced concurrently by rifampin. A 25-year-old male presented with high fever and a maculopapular rash with vesicles on the hands, which developed 2 weeks following regular administration of anti-tuberculosis drugs for tuberculous meningitis, including rifampin. Elevated liver enzymes, peripheral neuropathy, and decreased serum C3 and C4 levels were found. Interestingly, these symptoms were accompanied by severe hypotension. A serum-sickness-like reaction was considered after excluding other potential causes for the fever. A drug provocation test showed that the fever developed after oral administration of rifampin, suggesting that rifampin was the cause of the allergic reaction. However, hypotension, epigastric discomfort, and diarrhea also accompanied these symptoms, indicating that IgE-mediated type I hypersensitivity could be part of the serum sickness-like reaction. An intradermal skin test clearly showed an immediate positive reaction to rifampin. This case was diagnosed as concurrent serum-sickness-like reaction and anaphylaxis induced by rifampin. One drug may therefore induce combined allergic reactions via 2 or more simultaneous hypersensitivity responses. Keywords: Rifampin, serum sickness, anaphylaxis. Formats: Abstract Article PubReader PDF Figures + Tables References

Immunomodulatory Properties of HLA-G in Infectious Diseases

Journal of Immunology Research
Volume 2014 (2014), Article ID 298569, 14 pages
http://dx.doi.org/10.1155/2014/298569

Review Article

Laurence Amiot,^1,2,3,4 Nicolas Vu,^1,2,3 and Michel Samson^1,2,3

¹Institut National de la Santé et de la Recherche Médicale (Inserm), U.1085, Institut de Recherche sur la Santé, l'Environnement, et le Travail (IRSET), 2 Avenue du Pr. Leon Bernard CS 34317, 35043 Rennes, France
²Université de Rennes 1, 35043 Rennes, France
³Fédération de Recherche BioSit de Rennes UMS 3480, 35043 Rennes, France
⁴Department of Biology, University Hospital Pontchaillou, CHU Pontchaillou, 35033 Rennes, France

Received 8 January 2014; Revised 9 March 2014; Accepted 10 March 2014; Published 15 April 2014

Academic Editor: Roberta Rizzo

Copyright © 2014 Laurence Amiot et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions. The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. The relevance of studies on HLA-G expression lies in the well known inhibitory effect of this molecule on all cell types involved in innate and adaptive immunity, favoring escape from immune control. In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent. The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections. We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G. New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases.

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Birth after preeclamptic pregnancies: association with allergic sensitization and allergic rhinoconjunctivitis in late childhood; a historically matched cohort study

Research article

Kristine Kjer Byberg, Bjorn Ogland, Geir Egil Eide and Knut Øymar

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BMC Pediatrics 2014, 14:101  doi:10.1186/1471-2431-14-101

Published: 11 April 2014

Abstract (provisional)

Background

The development of allergic sensitization and allergic disease may be related to factors during intrauterine life, but the role of maternal preeclampsia is not known. We studied if maternal preeclampsia is associated with long-term allergic sensitization, allergic rhinoconjunctivitis, atopic dermatitis, asthma and with altered lung function in late childhood.

Methods

617 children participated in a 1:2 matched and controlled historical cohort study; 230 born after preeclamptic pregnancies and 387 born after normotensive pregnancies. Specific IgE in serum and lung function were measured at the age of 12.8 years and questionnaires on maternal and adolescent data were completed at the ages of 10.8 years (girls) and 11.8 years (boys), and at 12.8 years (both genders). The association between birth after preeclampsia and the main outcome measures allergic sensitization, allergic rhinoconjunctivitis, atopic dermatitis, asthma and lung function in late childhood were analysed with multiple regression analyses, including possible confounders.

Results

Severe maternal preeclampsia was associated with high level allergic sensitization (sum of specific IgE in serum >= 3.9 kU/l; the 25 percentile for all children being sensitized); odds ratio (OR): 3.79; 95% confidence interval (CI): (1.54, 9.32); p = 0.015 and with allergic rhinoconjunctivitis in offspring; OR: 2.22, 95% CI: (1.19, 4.14), p = 0.047. Preeclampsia was not associated with atopic dermatitis, asthma or altered lung function in late childhood.

Conclusion

Maternal preeclampsia was associated with allergic sensitization and allergic rhinoconjunctivitis in offspring in late childhood, but not with other atopic diseases.

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Association of serum Clara cell protein CC16 with respiratory infections and immune response to respiratory pathogens in elite athletes

Research

Marcin Kurowski, Janusz Jurczyk, Marzanna Jarz¿bska, Sylwia Moskwa, Joanna S Makowska, Hubert Krysztofiak and Marek L Kowalski

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Respiratory Research 2014, 15:45  doi:10.1186/1465-9921-15-45

Published: 15 April 2014

Abstract (provisional)

Background

Respiratory epithelium integrity impairment caused by intensive exercise may lead to exercise-induced bronchoconstriction. Clara cell protein (CC16) has anti-inflammatory properties and its serum level reflects changes in epithelium integrity and airway inflammation. This study aimed to investigate serum CC16 in elite athletes and to seek associations of CC16 with asthma or allergy, respiratory tract infections (RTIs) and immune response to respiratory pathogens.

Methods

The study was performed in 203 Olympic athletes. Control groups comprised 53 healthy subjects and 49 mild allergic asthmatics. Serum levels of CC16 and IgG against respiratory viruses and Mycoplasma pneumoniae were assessed. Allergy questionnaire for athletes was used to determine symptoms and exercise pattern. Current versions of ARIA and GINA guidelines were used when diagnosing allergic rhinitis and asthma, respectively.

Results

Asthma was diagnosed in 13.3% athletes, of whom 55.6% had concomitant allergic rhinitis. Allergic rhinitis without asthma was diagnosed in 14.8% of athletes. Mean CC16 concentration was significantly lower in athletes versus healthy controls and mild asthmatics. Athletes reporting frequent RTIs had significantly lower serum CC16 and the risk of frequent RTIs was more than 2-fold higher in athletes with low serum CC16 (defined as equal to or less than 4.99 ng/ml) . Athletes had significantly higher anti-adenovirus IgG than healthy controls while only non-atopic athletes had anti-parainfluenza virus IgG significantly lower than controls. In all athletes weak correlation of serum CC16 and anti-parainfluenza virus IgG was present (R = 0.20, p < 0.01). In atopic athletes a weak positive correlations of CC16 with IgG specific for respiratory syncytial virus (R = 0.29, p = 0.009), parainfluenza virus (R = 0.31, p = 0.01) and adenovirus (R = 0.27, p = 0.02) were seen as well.

Conclusions

Regular high-load exercise is associated with decrease in serum CC16 levels. Athletes with decreased CC16 are more susceptible to respiratory infections. Atopy may be an additional factor modifying susceptibility to infections in subjects performing regular high-load exercise.

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Childhood Overweight/Obesity and Pediatric Asthma: The Role of Parental Perception of Child Weight Status

Nutrients 2013, 5(9), 3713-3729; doi:10.3390/nu5093713

Project Report

Salma M. A. Musaad ¹, Katie N. Paige ², Margarita Teran-Garcia ^2,3, Sharon M. Donovan ^2,3, Barbara H. Fiese ^1,*  and the STRONG Kids Research Team ⁴

¹ Family Resiliency Center, Department of Human and Community Development, University of Illinois at Urbana Champaign, 904 W. Nevada, MC-081, Urbana, IL 61801, USA² Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA³ Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA⁴ The STRONG Kids Team includes Kristen Harrison, Kelly Bost, Brent McBride, Sharon Donovan, Diana Grigsby-Toussaint, Juhee Kim, Janet Liechty, Angela Wiley, Margarita Teran-Garcia and Barbara Fiese

* Author to whom correspondence should be addressed.

Received: 2 July 2013; in revised form: 13 August 2013 / Accepted: 4 September 2013 / Published: 23 September 2013

(This article belongs to the Special Issue Nutrition and Respiratory Disease)

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Abstract: Childhood obesity and asthma are on the rise in the U.S. Clinical and epidemiological data suggest a link between the two, in which overweight and obese children are at higher risk for asthma. Prevention of childhood obesity is preferred over treatment, however, in order to be receptive to messages, parents must perceive that their child is overweight. Many parents do not accurately assess their child’s weight status. Herein, the relation between parental perceptions of child weight status, observed body mass index (BMI) percentiles, and a measure of child feeding practices were explored in the context of asthma, food allergy, or both. Out of the children with asthma or food allergy that were classified as overweight/obese by BMI percentiles, 93% were not perceived as overweight/obese by the parent. Mean scores for concern about child weight were higher in children with both asthma and food allergy than either condition alone, yet there were no significant differences among the groups in terms of pressure to eat and restrictive feeding practices. In summary, parents of children with asthma or food allergy were less likely to recognize their child’s overweight/obese status and their feeding practices did not differ from those without asthma and food allergy.

Keywords: childhood obesity; pediatric asthma; food allergy; parental perception

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MDPI and ACS Style

Musaad, S.M.A.; Paige, K.N.; Teran-Garcia, M.; Donovan, S.M.; Fiese, B.H.; the STRONG Kids Research Team Childhood Overweight/Obesity and Pediatric Asthma: The Role of Parental Perception of Child Weight Status. Nutrients 2013, 5, 3713-3729.

AMA Style

Musaad SMA, Paige KN, Teran-Garcia M, Donovan SM, Fiese BH, the STRONG Kids Research Team. Childhood Overweight/Obesity and Pediatric Asthma: The Role of Parental Perception of Child Weight Status. Nutrients. 2013; 5(9):3713-3729.

Chicago/Turabian Style

Musaad, Salma M.A.; Paige, Katie N.; Teran-Garcia, Margarita; Donovan, Sharon M.; Fiese, Barbara H.; the STRONG Kids Research Team. 2013. "Childhood Overweight/Obesity and Pediatric Asthma: The Role of Parental Perception of Child Weight Status." Nutrients 5, no. 9: 3713-3729.

An interaction library for the FcεRI signaling network

HYPOTHESIS & THEORY ARTICLE

Front. Immunol., 15 April 2014 | doi: 10.3389/fimmu.2014.00172

Lily A. Chylek^1,2, David A. Holowka¹, Barbara A. Baird¹* and

 William S. Hlavacek²*

• 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA
• 2Los Alamos National Laboratory, Theoretical Division, Center for Non-linear Studies, Los Alamos, NM, USA

Antigen receptors play a central role in adaptive immune responses. Although the molecular networks associated with these receptors have been extensively studied, we currently lack a systems-level understanding of how combinations of non-covalent interactions and post-translational modifications are regulated during signaling to impact cellular decision-making. To fill this knowledge gap, it will be necessary to formalize and piece together information about individual molecular mechanisms to form large-scale computational models of signaling networks. To this end, we have developed an interaction library for signaling by the high-affinity IgE receptor, FcεRI. The library consists of executable rules for protein–protein and protein–lipid interactions. This library extends earlier models for FcεRI signaling and introduces new interactions that have not previously been considered in a model. Thus, this interaction library is a toolkit with which existing models can be expanded and from which new models can be built. As an example, we present models of branching pathways from the adaptor protein Lat, which influence production of the phospholipid PIP3 at the plasma membrane and the soluble second messenger IP3. We find that inclusion of a positive feedback loop gives rise to a bistable switch, which may ensure robust responses to stimulation above a threshold level. In addition, the library is visualized to facilitate understanding of network circuitry and identification of network motifs.

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Keywords: immunoreceptor signaling, IgE receptors (FcεRI), mast cells, knowledge engineering, computational modeling, network motifs, feed-forward loops, visualization

Citation: Chylek LA, Holowka DA, Baird BA and Hlavacek WS (2014) An interaction library for the FcεRI signaling network.Front. Immunol. 5:172. doi: 10.3389/fimmu.2014.00172

Received: 11 December 2013; Accepted: 31 March 2014;
Published online: 15 April 2014.

Edited by:

Rob J. De Boer, Utrecht University, Netherlands

Reviewed by:

Christopher E. Rudd, University of Cambridge, UK
Grégoire Altan-Bonnet, Memorial Sloan-Kettering Cancer Center, USA

Copyright: © 2014 Chylek, Holowka, Baird and Hlavacek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Barbara A. Baird, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA e-mail: bab13@cornell.edu;
William S. Hlavacek, Los Alamos National Laboratory, Theoretical Division, Center for Nonlinear Studies, Los Alamos, NM 87545, USA e-mail: wish@lanl.gov

Sensitizing Properties of Proteins: State of the Science

The Protein Allergenicity Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) organized a symposium on the sensitizing properties of proteins in Prague in April 2012. Experts discussed known mechanisms by which proteins may cause sensitization, shared information about experimental models for predicting protein sensitizing potential, and explored whether such experimental techniques may be applicable in regulatory settings. In addition to an Executive Summary, three accompanying reviews address the critical factors and methods for assessing allergic sensitization. Publication of this collection was funded by ILSI Health and Environmental Sciences Institute, a non-profit organization.

Collection published: 15 April 0014

Last updated: 15 April 2014

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