A blog that publishes updates and open access scientific papers about allergy, asthma and immunology. Editor: Juan Carlos Ivancevich, MD. Specialist in Allergy & Immunology
March 2, 2015
Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
Abstract (provisional)
Background Surfactant protein D (SP-D), a pattern recognition molecule, has been shown to play roles in host defense such as opsonisation, aggregation of pathogens, and modulation of the inflammatory response. In light of infection-induced exacerbations and damage to the airway epithelium from inflammation, these functions of SP-D make it relevant in the development and pathogenesis of asthma.
February 27, 2015
H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis
Abstract
BACKGROUND:
February 26, 2015
Evaluation of patients’ expectations and benefits in the treatment of allergic rhinitis with a new tool: the patient benefit index – the benefica study
Research
Pascal Demoly1*, Michel Aubier234, Frédéric de Blay5, François Wessel6, Pierre Clerson7 and Pascal Maigret8
Abstract (provisional)
Background Symptoms of allergic rhinitis (AR) have a detrimental effect on quality of life. The AR-Patient Benefit Index (AR-PBI), a specific self-assessment tool has been developed to assess treatment-related benefit in two separate sections: the Patient Needs Questionnaire (PNQ) which explores the patient’s expectations before treatment and the Patient Benefit Questionnaire (PBQ) which evaluates treatment benefit. For the PNQ, three dimensions summarized patients’ expectations: symptoms, social life and emotional state, thus covering a larger field than symptomatic relief.
Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients
Research
Thuy-My Le1*, Els van Hoffen110, Ischa Kummeling12, James Potts2, Barbara K Ballmer-Weber3, Carla AFM Bruijnzeel-Koomen1, Ans FM Lebens1, Jonas Lidholm4, Titia M Lindner1, Alan Mackie5, EN Clare Mills6, Ronald van Ree7, Stefan Vieths8, Montserrat Fernández-Rivas9, Peter G Burney2 and André C Knulst1
Abstract (provisional)
Background It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.
Objective To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.
Objective To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.
February 25, 2015
Evaluation of a web-based asthma self-management system: a randomised controlled pilot trial
Research article
John M Wiecha1*, William G Adams2, Denis Rybin3, Maria Rizzodepaoli4, Jeremy Keller5and Jayanti M Clay6
Abstract (provisional)
Background Asthma is the most common chronic condition of childhood and disproportionately affects inner-city minority children. Low rates of asthma preventer medication adherence is a major contributor to poor asthma control in these patients.
A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroids
Research
Christian Vogelberg1*, Petra Moroni-Zentgraf2, Migle Leonaviciute-Klimantaviciene3, Ralf Sigmund4, Eckard Hamelmann5, Michael Engel2 and Stanley Szefler6
Abstract
Background
A considerable number of children with asthma remain symptomatic despite treatment with inhaled corticosteroids, resulting in significant morbidity, reduced quality of life, increased healthcare costs and lost school days.
February 24, 2015
Insights and advances in chronic urticaria: a Canadian perspective
Review
Gordon Sussman1*, Jacques Hébert2, Wayne Gulliver3, Charles Lynde1, Susan Waserman4, Amin Kanani5, Moshe Ben-Shoshan6, Spencer Horemans1, Carly Barron1,Stephen Betschel1, William H Yang7, Jan Dutz5, Neil Shear1, Gina Lacuesta8, Peter Vadas1, Kenneth Kobayashi7, Hermenio Lima4 and F Estelle R Simons9
Abstract
In the past few years there have been significant advances which have changed the face of chronic urticaria. In this review, we aim to update physicians about clinically relevant advances in the classification, diagnosis and management of chronic urticaria that have occurred in recent years.
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