The expanding role of immunopharmacology: IUPHAR Review 16

1. Ekaterini Tiligada^1,2,*, 
2. Masaru Ishii³, 
3. Carlo Riccardi⁴, 
4. Michael Spedding⁵, 
5. Hans-Uwe Simon⁶, 
6. Mauro Martins Teixeira⁷, 
7. Mario Landys Chovel Cuervo⁸, 
8. Stephen T Holgate⁹ and
9. Francesca Levi-Schaffer¹⁰

British Journal of Pharmacology

1. 1. Volume 172, Issue 17, pages 4217–4227, September 2015
   2. Abstract: 
   Drugs targeting the immune system such as corticosteroids, antihistamines and immunosuppressants have been widely exploited in the treatment of inflammatory, allergic and autoimmune disorders during the second half of the 20th century. The recent advances in immunopharmacological research have made available new classes of clinically relevant drugs.

Drug Hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group

1. Eva Gomes^1,*, 
2. Knut Brockow², 
3. Semanur Kuyucu³, 
4. Francesca Saretta⁴, 
5. Francesca Mori⁵, 
6. Natalia Blanca-Lopez⁶, 
7. Hagen Ott⁷,
8. Marina Atanaskovic-Markovic⁸, 
9. Mona Kidon⁹, 
10. Jean-Christoph Caubet¹⁰, 
11. Ingrid Terreehorst¹¹ and
12. The ENDA/EAACI Drug Allergy Interest Group

Allergy

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) DOI: 10.1111/all.12774

Abstract: When questioned, about 10% of the parents report suspected hypersensitivity to at least one drug in their children. However, only a few of these reactions can be confirmed as allergic after a diagnostic workup. There is still a lack of knowledge on drug hypersensitivity epidemiology, clinical spectrum and appropriate diagnostic methods particularly in children.

Evaluation of candidate vaccine approaches for MERS-CoV

NATURE COMMUNICATIONS | ARTICLE OPEN

• Lingshu Wang,
• Wei Shi,
• M. Gordon Joyce,
• Kayvon Modjarrad,
• Yi Zhang,
• Kwanyee Leung,
• Christopher R. Lees,
• Tongqing Zhou,
• Hadi M. Yassine,
• Masaru Kanekiyo,
• Zhi-yong Yang,
• Xuejun Chen,
• Michelle M. Becker,
• Megan Freeman,
• Leatrice Vogel,
• Joshua C. Johnson,
• Gene Olinger,
• John P. Todd,
• Ulas Bagci,
• Jeffrey Solomon
• et al.

Nature Communications

 

6,

 

Article number:

 

7712

 

doi:10.1038/ncomms8712

Received

 

21 April 2015 

Accepted

 

03 June 2015 

Published

 

28 July 2015

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Abstract

• Abstract• 
• Introduction• 
• Results• 
• Discussion• 
• Methods• 
• Additional information• 
• Accession codes•
• References• 
• Acknowledgements• 
• Author information• 
• Supplementary information

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) as a cause of severe respiratory disease highlights the need for effective approaches to CoV vaccine development. Efforts focused solely on the receptor-binding domain (RBD) of the viral Spike (S) glycoprotein may not optimize neutralizing antibody (NAb) responses.

Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis

Research

Katrin König¹, Christine Klemens¹, Katharina Eder¹, Marion San Nicoló¹, Sven Becker¹², Matthias F. Kramer¹ andMoritz Gröger^1*

Allergy, Asthma & Clinical Immunology 2015, 11:26  doi:10.1186/s13223-015-0093-x

Abstract

Background

New therapeutic approaches with biologic agents such as anti-cytokine antibodies are currently on trial for the treatment of asthma, rhinosinusitis or allergic diseases necessitating patient selection by biomarkers. Allergic rhinitis (AR), affecting about 20 % of the Canadian population, is an inflammatory disease characterised by a disequilibrium of T-lymphocytes and tissue eosinophilia.

Atopic dermatitis: A cross-sectional (descriptive) study of 100 cases

E-IJD ORIGINAL ARTICLE

Year : 2015  |  Volume : 60  |  Issue : 5  |  Page : 519

Virendra N Sehgal1, Govind Srivastava2, Ashok K Aggarwal2, Deepti Saxena2, Kingshuk Chatterjee3, Ananta Khurana4 1 Dermato Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi, India 2 Skin Institute, School of Dermatology, Greater Kailash, New Delhi, India 3 Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India 4 Department of Dermatology, Dr RML hospital and Postgraduate Institute of Medical Education and research (PGIMER), New Delhi, India

Abstract   Background: Atopic dermatitis is a distinct age-related clinical entity. Its etiopathogenesis is largely insubstantial. Nevertheless, it seems to be an outcome of interplay of maternal and inheritance, pregnancy/intrauterine and environmental factors. Besides, immune dysregulation, and nutritional supplements also play essential roles. Its diagnosis has been perpetuated by three or more major/minor criteria.

Sublingual grass and ragweed immunotherapy: Clinical considerations—a PRACTALL consensus report

James T. Li, MD, PhD

,

 David I. Bernstein, MD

,

 Moises A. Calderon, MD, PhD

,

 Thomas B. Casale, MD

,

Linda Cox, MD

,

 Giovanni Passalacqua, MD

,

 Oliver Pfaar, MD

,

 Nikolaos G. Papadopoulos, MD

Received: May 18, 2015; Received in revised form: June 25, 2015; Accepted: June 30, 2015; Published Online:September 11, 2015

Publication stage: In Press Corrected Proof

DOI: http://dx.doi.org/10.1016/j.jaci.2015.06.046

   Article Info

• Abstract
• Full Text
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Sublingual allergen immunotherapy provides a new option for patients with allergic rhinitis in the United States. The efficacy of these sublingual immunotherapy tablets in the treatment of allergic rhinitis has been firmly established in large multicenter clinical trials. In addition, the clinical benefits of sublingual immunotherapy might persist after treatment is discontinued.

Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

Research

Marko Topalovic¹, Eric Derom², Christian R. Osadnik³⁴⁵⁶, Thierry Troosters¹³, Marc Decramer¹, Wim Janssens^1* andon behalf of the Belgian Pulmonary Function Study Investigators

Respiratory Research 2015, 16:88  doi:10.1186/s12931-015-0252-0

Abstract

Background

Airway resistance (R _AW ) and specific airway conductance (sG _AW ) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of R _AW and sG _AW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD.

The GINA asthma strategy report: what’s new for primary care?

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Abstract

NPJ Prim Care Respir Med. 2015; 25: 15050.

Helen K Reddel^1,* and Mark L Levy^2,3, on behalf of the Global Initiative for Asthma Scientific Committee and Dissemination and Implementation Committee

Author information ► Article notes ► Copyright and License information ►

Abstract

The Global Initiative for Asthma (GINA) was established in 1993 by the World Health Organization and National Heart Lung and Blood Institute to develop a global strategy for managing and preventing asthma. GINA reports, now funded independently through the sale of GINA products, have provided the foundation for many national guidelines. They are prepared by international experts from primary, secondary and tertiary care, and are annually updated following a review of evidence.