The Social Value of Childhood Vaccination in the United States

Vaccination of children born in the United States in 2009 will save 1.2 million quality-adjusted life-years, generating $184 billion in social value net of vaccination costs.

Tomas J. Philipson, PhD; Julia Thornton Snider, PhD; Ayman Chit, PhD; Sarah Green, BA; Philip Hosbach, BA; Taylor Tinkham Schwartz, MPH; Yanyu Wu, PhD; and Wade M. Aubry, MD

ABSTRACT

Objectives: To determine the lifetime social value of using the guideline-recommended vaccines for children born in the United States in 2009. 

Study Design: This study utilized an economic model with parameter values sourced from clinical and observational data, as well as the literature. 

Immunopathogenesis of granulomas in chronic autoinflammatory diseases

Review

Citation: Clinical & Translational Immunology (2016) 5, e118; doi:10.1038/cti.2016.75
Published online 16 December 2016

OPEN

Wilhelmina Maria Cornelia Timmermans^1,2,3, Jan Alexander Michael van Laar^1,2, Petrus Martinus van Hagen^1,2 and Menno Cornelis van Zelm³

1. ¹Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
2. ²Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
3. ³Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia

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Abstract

Granulomas are clusters of immune cells. These structures can be formed in reaction to infection and display signs of necrosis, such as in tuberculosis. Alternatively, in several immune disorders, such as sarcoidosis, Crohn’s disease and common variable immunodeficiency, non-caseating granulomas are formed without an obvious infectious trigger. Despite advances in our understanding of the human immune system, the pathogenesis underlying these non-caseating granulomas in chronic inflammatory diseases is still poorly understood. Here, we review the current knowledge about the immunopathogenesis of granulomas, and we discuss how the involved immune cells can be targeted with novel therapeutics.

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• Abstract
• Introduction
• Chronic autoinflammatory diseases with granuloma formation
• Key players in granuloma pathogenesis
• Therapeutic implications
• Conclusions
• Conflict of interest
• References
• Acknowledgements
• Figures and Tables

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Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach

Clinical and Translational Allergy

BRIEF COMMUNICATION

 

OPEN ACCESS

• Diana Margarida Gonçalves Solha Pereira da SilvaEmail authorView ORCID ID profile,
• Teresa Maria Silva Vieira,
• Ana Maria Alves Pereira,
• André Miguel Afonso de Sousa Moreira and
• José Luís Dias Delgado

Clinical and Translational Allergy20166:46

DOI: 10.1186/s13601-016-0136-5

©  The Author(s) 2016

Received: 18 June 2016

Accepted: 29 November 2016

Published: 22 December 2016

Abstract

Background

Challenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and an allergen microarray test in the identification of IgE-mediated cross-reactive food allergens in patients with suspected FDEIA or food-dependent exercise-induced urticaria and panallergen sensitization.

Pesticides Are Associated with Allergic and Non-Allergic Wheeze among Male Farmers

Environ Health Perspect; DOI:10.1289/EHP315

Jane A. Hoppin,1 David M. Umbach,2 Stuart Long,3 Stephanie J. London,4 Paul K. Henneberger,5 Aaron Blair,6 Michael Alavanja,6 Laura E. Beane Freeman,6 and Dale P. Sandler4

Author Affiliations open

 PDF Version (392 KB)

• Abstract
• About This Article
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• 
  
• Background: Growing evidence suggests that pesticide use may contribute to respiratory symptoms.
  Objective: To evaluate the association of currently used pesticides with allergic and non-allergic wheeze among male farmers.

Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis

Open AccessArticle

Nutrients 2016, 8(12), 789; doi:10.3390/nu8120789
Min Jung Kim ¹

,Soo-Nyung Kim ²

,Yang Won Lee ^1,3,* ,Yong Beom Choe ^1,3

 andKyu Joong Ahn ^1,3

¹Department of Dermatology, Konkuk University School of Medicine, Seoul 05030, Korea²Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul 05030, Korea³Research Institute of Medical Science, Konkuk University, Seoul 05030, Korea

Abstract
Recent literature has highlighted the possible role of vitamin D in atopic dermatitis (AD), and that vitamin D supplementation might help to treat AD. This study determined the relationship between vitamin D level and AD, and assessed the efficacy of vitamin D supplementation. We searched the MEDLINE, EMBASE, and Cochrane databases up to May 2015. Observational studies and randomized controlled trials were included based on the available data on the serum 25-hydroxyvitamin D (25(OH)D) level and quantified data available for severity assessed using the Scoring Atopic Dermatitis (SCORAD) index or Eczema Area and Severity Index (EASI) score.

Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma

Aparna Sundaram,1 Chun Chen,1 Amin Khalifeh-Soltani,2 Amha Atakilit,1 Xin Ren,1 Wenli Qiu,1 Hyunil Jo,3 William DeGrado,3 Xiaozhu Huang,1 and Dean Sheppard1

First published December 5, 2016 - More info

Research Article Muscle biology Pulmonology

Abstract

Treatment options are limited for severe asthma, and the need for additional therapies remains great. Previously, we demonstrated that integrin αvβ6-deficient mice are protected from airway hyperresponsiveness, due in part to increased expression of the murine ortholog of human chymase. Here, we determined that chymase protects against cytokine-enhanced bronchoconstriction by cleaving fibronectin to impair tension transmission in airway smooth muscle (ASM).

From the Medical Board of the National Psoriasis Foundation: Treatment targets for plaque psoriasis

April W. Armstrong, MD, MPHPress enter key for correspondence informationPress enter key to Email the author

, 

Michael P. Siegel, PhD

, 

Jerry Bagel, MD

, 

Erin E. Boh, MD, PhD

, 

Megan Buell

, 

Kevin D. Cooper, MD

, 

Kristina Callis Duffin, MD, MS

, 

Lawrence F. Eichenfield, MD

, 

Amit Garg, MD

, 

Joel M. Gelfand, MD, MSCE

, 

Alice B. Gottlieb, MD, PhD

, 

John Y.M. Koo, MD

, 

Neil J. Korman, MD, PhD

, 

Gerald G. Krueger, MD

, 

Mark G. Lebwohl, MD

, 

Craig L. Leonardi, MD

, 

Arthur M. Mandelin, MD, PhD

, 

M. Alan Menter, MD

, 

Joseph F. Merola, MD, MMSC

, 

David M. Pariser, MD

, 

Ronald B. Prussick, MD, FRCP

, 

Caitriona Ryan, MD

, 

Kara N. Shah, MD

, 

Jeffrey M. Weinberg, MD

, 

MaryJane O.U. Williams, MD

, 

Jashin J. Wu, MD

, 

Paul S. Yamauchi, MD, PhD

, 

Abby S. Van Voorhees, MD

Open Access

DOI: http://dx.doi.org/10.1016/j.jaad.2016.10.017

Article Info

• Abstract

• Full Text
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Background

An urgent need exists in the United States to establish treatment goals in psoriasis.

Objective

We aim to establish defined treatment targets toward which clinicians and patients with psoriasis can strive to inform treatment decisions, reduce disease burden, and improve outcomes in practice.

Methods

The National Psoriasis Foundation conducted a consensus-building study among psoriasis experts using the Delphi method. The process consisted of: (1) literature review, (2) pre-Delphi question selection and input from general dermatologists and patients, and (3) 4 Delphi rounds.

Applying Multiple Data Collection Tools to Quantify Human Papillomavirus Vaccine Communication on Twitter

Journal of Medical Internet Research 
Vol 18, No 12 (2016): December

• Article
• Cited By (0)
• Tweetations (6)
• Metrics

Original Paper

• Philip M Massey^1*, MPH, PhD ; 
• Amy Leader^2*, MPH, DrPH ; 
• Elad Yom-Tov^3*, MSc, PhD ; 
• Alexandra Budenz^1*, MA ; 
• Kara Fisher^4*, MPH ; 
• Ann C Klassen^1*, PhD 

¹Department of Community Health and Prevention, Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States

²Division of Population Science, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, United States

³Microsoft Research Israel, Herzeliya, Israel

⁴Department of Biostatistics and Epidemiology, Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States

*all authors contributed equally

ABSTRACT

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. There are several vaccines that protect against strains of HPV most associated with cervical and other cancers. Thus, HPV vaccination has become an important component of adolescent preventive health care. As media evolves, more information about HPV vaccination is shifting to social media platforms such as Twitter. Health information consumed on social media may be especially influential for segments of society such as younger populations, as well as ethnic and racial minorities.