Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583 (Published 15 February 2017)Cite this as: BMJ 2017;356:i6583

Adrian R Martineau, professor of respiratory infection and immunity1 2, 

David A Jolliffe, postdoctoral research fellow1, 

Richard L Hooper, reader in medical statistics1, 

Lauren Greenberg, medical statistician1, 

John F Aloia, professor of medicine3, 

Peter Bergman, associate professor4, 

Gal Dubnov-Raz, consultant paediatrician5, 

Susanna Esposito, professor of paediatrics6, 

Davaasambuu Ganmaa, assistant professor7, 

Adit A Ginde, professor of emergency medicine8, 

Emma C Goodall, assistant professor9, 

Cameron C Grant, associate professor10, 

Christopher J Griffiths, professor of primary care1 2 11, 

Wim Janssens, professor of pneumonology12, 

Ilkka Laaksi, chief administrative medical officer13, 

Semira Manaseki-Holland, senior clinical lecturer14, 

David Mauger, professor of public health sciences and statistics15, 

David R Murdoch, professor of pathology16, 

Rachel Neale, associate professor17, 

Judy R Rees, assistant professor18, 

Steve Simpson Jr, postdoctoral research fellow19, 

Iwona Stelmach, professor of paediatric allergy20, 

Geeta Trilok Kumar, associate professor21, 

Mitsuyoshi Urashima, professor of molecular epidemiology22, 

Carlos A Camargo Jr, professor of emergency medicine, medicine, and epidemiology23

Author affiliations

1. Correspondence to: A R Martineau a.martineau@qmul.ac.uk

Abstract

Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.

Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.

Self-assessment of Allergic Rhinitis and Asthma (SACRA) Questionnaire-based Allergic Rhinitis Treatment Improves Asthma Control in Asthmatic Patients with Allergic Rhinitis

Internal Medicine
Vol. 56 (2017) No. 1 p. 31-39

Language:      English     Japanese   

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http://doi.org/10.2169/internalmedicine.56.7251

ORIGINAL ARTICLES

Masanori Yasuo¹⁾, Yoshiaki Kitaguchi^{1) 2)}, Yoshimichi Komatsu³⁾, Mineyuki Hama¹⁾, Tomonobu Koizumi⁴⁾, Toshihiko Agatsuma⁵⁾, Takashi Ichiyama^{1) 6)}, Akane Kato^{1) 3)}, Hideaki Moteki⁷⁾, Masayuki Hanaoka¹⁾

1) The First Department of Internal Medicine, Shinshu University School of Medicine, Japan 2) Department of Respiratory Medicine, Okaya City Hospital, Japan 3) Department of Respiratory Medicine, Suwa Redcross Hospital, Japan 4) Comprehensive Cancer Center, Division of Clinical Oncology, Shinshu University School of Medicine, Shinshu University Hospital, Japan 5) Department of Respiratory Medicine, Shinshu Ueda Medical Center, Japan 6) Department of Respiratory Medicine, Nagano Municipal Hospital, Japan 7) Department of Otorhinolaryngology, Shinshu University School of Medicine, Japan

 Released on J-STAGE 20170101  

Keywords: allergic rhinitis, asthma, asthma control test (ACT), pulmonary function tests, SACRA questionnaire, visual analogue scale

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• Abstracts
• References(24)
• Supplementary materials(3)

Objective This study was conducted to investigate whether the add-on treatment of allergic rhinitis (AR) based on the Self-assessment of Allergic Rhinitis and Asthma (SACRA) questionnaire for assessing AR control improves both AR and asthma control in asthmatic patients with AR.

Methods This multi-center prospective study was performed in Nagano prefecture, Japan. Two hundred five asthmatic patients and 23 respiratory physicians participated in the study. We administered add-on AR treatments based on the results of the SACRA questionnaire. After the first SACRA questionnaire, 67 asthmatic patients agreed to receive an add-on AR treatment. Three months after the AR treatment, a secondary SACRA questionnaire, asthma control test (ACT), and pulmonary function tests were performed.

Biomarkers for Monitoring Clinical Efficacy of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Allergic Asthma: an EAACI Position Paper.

Allergy. 2017 Feb 2. doi: 10.1111/all.13138. [Epub ahead of print]

Shamji MH1,2,3, Kappen JH1,2,4,3, Akdis M5, Jensen-Jarolim E6,7, Knol EF8, Kleine-Tebbe J9, Bohle B10, Chaker AM11,12, Till SJ13, Valenta R14, Poulsen LK15, Calderon MA1,2,3, Demoly P16, Pfaar O17, Durham LJ1,2,3, Schmidt-Weber CB11,12.

Author information

Abstract

Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma (1-12). AIT has disease modifying properties and confers long-term clinical benefit after cessation of treatment (6, 7, 13-17). AIT is routinely used in daily practice and can be administered either subcutaneously (SCIT) or sublingually (SLIT) (3-12).

Pollen and Spore Counting Part 2 (Barnes)

Dr. Barnes continues his discussion of how to do pollen spore counts. 

ACAAICOLA

Pollen and Spore Counting Part 1 (Barnes)

Dr. Charles Barnes describes how pollen and mold counts are performed

ACAAICOLA

Allergies in urban versus countryside settings in Poland as part of the Epidemiology of the Allergic Diseases in Poland (ECAP) study – challenge the early differential diagnosis

Original paper

Edyta Krzych-Fałta, Konrad Furmańczyk, Barbara Piekarska, Aneta Tomaszewska, Adam Sybilski, Bolesław K. Samoliński

Adv Dermatol Allergol 2016; XXXIII (5): 359-368

DOI: https://doi.org/10.5114/pdia.2016.61338

Article file

- Allergies in urban.pdf  [0.18 MB]

 

High-dose anti-histamine use and risk factors in children with urticaria

Pınar Uysal 1 ,  Sibelnur Avcil 2 ,  Duygu Erge 1 

1 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk Allerji ve Klinik İmmunoloji Bilim Dalı, Aydın, Türkiye 

2 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Aydın, Türkiye 

Turk Pediatri Ars 2016; 51: 198-203

DOI: 10.5152/TurkPediatriArs.2016.

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Abstract

Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.

Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications

1. Previous article in issue: The current and future role of biomarkers in type 2 cytokine-mediated asthma management
2. Next article in issue: Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma

Volume 47, Issue 2 February 2017 Pages 161–175 

• DOI: 10.1111/cea.12880View/save citation 
• Summary
  Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual patient disease triggers and response to therapy. Several asthma phenotypes have now been identified, each defined by a unique interaction between genetic and environmental factors, including inflammatory, clinical and trigger-related phenotypes.