D’Erme AM, Fidanzi C, Bevilacqua M, et al. JAMA Dermatol. 2024;160(10):1112–1115. doi:10.1001/jamadermatol.2024.3178
Key Points
Question Which are the possible cutaneous and serological markers that can be used to predict the development of atopic dermatitis (AD) in infants?
Findings In this observational study, serum biomarkers, transepidermal water loss, and hydration rate of 40 infants were evaluated. There were statistically significant higher CCL17 and IL-31 cord blood serum levels in the infants who developed AD, and anterior cubital fossa transepidermal water loss values at 1, 6, and 12 months of age were also considerably higher in infants who developed AD.
Meaning AD is a chronic skin disease for which some identifiable cutaneous or serological markers may be capable of predicting its development.
Abstract
Importance Atopic dermatitis (AD) is the most prevalent chronic skin condition characterized by inflammation and itching. Currently, there is no reliable method for identifying which newborns might have an increased risk of developing AD.