Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort

Bradley E. Chipps,¹ Robert S. Zeiger,² Alejandro Dorenbaum,³ Larry Borish,⁴ Sally E. Wenzel,⁵ Dave P. Miller,⁶ Mary Lou Hayden,⁷ Eugene R. Bleecker,⁸ F. Estelle R. Simons,⁹ Stanley J. Szefler,¹⁰ Scott T. Weiss,¹¹ Tmirah Haselkorn,³and TENOR Study Group

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Abstract

Patients with severe or difficult-to-treat asthma account for substantial asthma morbidity, mortality, and healthcare burden despite comprising only a small proportion of the total asthma population. TENOR, a multicenter, observational, prospective cohort study was initiated in 2001. It enrolled 4,756 adults, adolescents and children with severe or difficult-to-treat asthma who were followed semi-annually and annually for three years, enabling insight to be gained into this understudied population. A broad range of demographic, clinical, and patient self-reported assessments were completed during the follow-up period. Here, we present key findings from the TENOR registry in relation to asthma control and exacerbations, including the identification of specific subgroups found to be at particularly high-risk. Identification of the factors and subgroups associated with poor asthma control and increased risk of exacerbations can help physicians design individual asthma management, and improve asthma-related health outcomes for these patients.

Keywords: Severe asthma, Difficult-to-treat asthma, Asthma control, Exacerbation

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