December 13, 2012

Aetiological Factors Associated with Chronic Urticaria in Children: A Systematic Review


Aetiological Factors Associated with Chronic Urticaria in Children: 

A Systematic Review

Carlo Caffarelli1Barbara Cuomo2Fabio Cardinale3Salvatore Barberi4Carlotta Povesi Dascola1Fabio Agostinis5,Fabrizio Franceschini6 and Roberto Bernardini7
1Clinica Pediatrica, Dipartimento di Medicina Clinica e Sperimentale, Università di Parma, Azienda 
Ospedaliera-Universitaria, Parma, 2UOC Pediatria, Ospedale di Viterbo, Viterbo, 3UOC Medicina 
Pediatrica e Pneumo-Allergoimmunologia, Azienda Ospedaliero-Universitaria “Policlinico-Giovanni XXIII”, 
Bari, 4Ospedale S.Paolo, Clinica Pediatrica, Università di Milano 5USC di Pediatria, OORR di Bergamo, 
Bergamo, 6U.O Pediatria, Ospedale G Salesi, Ancona, and 7UOC Pediatria, Nuovo Ospedale S.Giuseppe, 
Empoli, Italy


Chronic urticaria is a distressing condition with high costs. The aim of this literature review was to assess the
 relative frequency of causes of chronic urticaria in childhood and to provide guidance on which laboratory 
tests should be performed. Using PubMed, EMBASE and Cochrane databases, the literature from 1966 to 
2010 (week 25) was systematically reviewed. Data from studies conducted on children who had had 
urticaria for at least 6 weeks, and assessing at least 3 different causes of urticaria, were analysed by 
reviewers using independent extraction. Six studies, all of low quality, met the inclusion criteria. 
Idiopathic and physical urticaria were common. Infections, autoimmunity and allergy were also reported. 
We conclude that children with chronic urticaria not caused by physical stimuli should undergo tests for 
allergy or infections only when there is a history of cause–effect correlation. High-quality trials are 
warranted to evaluate the causes of chronic urticaria in childhood. 

Key words: chronic urticaria; 
childhood; systematic review; physical urticaria; infections; idiopathic urticaria; autoimmune urticaria; 
allergy; food allergy; additive.

Open Access 





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