Current Allergy and Asthma Reports© The Author(s) 201310.1007/s11882-013-0338-z
RHINITIS (JN BARANIUK AND JJ OPPENHEIMER, SECTION EDITORS)
The Role of Interleukin-33 in Rhinitis
(1)
Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, ul. Ceglana 35, 40-952 Katowice, Poland
(2)
Medical University of Silesia, Katowice, Poland
Published online: 5 February 2013
Abstract
IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 acting as an endogenous danger signal is termed an alarmin. As such, this cytokine is considered to play a crucial role in an allergic inflammatory disease such as rhinitis. Recent investigations regarding the IL-33/ST2 axis involvement in Th2 inflammatory response and pathogenesis of rhinitis have been reviewed. The role of IL-33 as a novel promising therapeutic target has also been discussed.
Keywords
Interleukin-33 IL-33/ST2 Th2-mediated response Rhinitis Pathogenesis Allergic inflammation T cells Basophils Eosinophils Mast cells
No comments:
Post a Comment