Characteristics of patients preferring once-daily controller therapy for asthma and COPD

Online first

Research Paper

Characteristics of patients preferring once-daily controller therapy for asthma and COPD: a retrospective cohort study

^*David Price^1,2, Amanda J Lee³, Erika J Sims^2,4, Linda Kemp², Elizabeth V Hillyer², Alison Chisholm², Julie von Ziegenweidt², Angela Williams<sup>5

1</sup> Academic Centre of Primary Care, University of Aberdeen, UK

² Research in Real Life, Cambridge, UK

³ Division of Applied Health Sciences, University of Aberdeen, UK

⁴ Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK

⁵ GlaxoSmithKline R & D, Uxbridge, UK (currently with MedImmune, Cambridge, UK)

Received 7 September 2012 • Accepted 22 December 2012 • Online 4 March 2013


Abstract
BACKGROUND: Patient preference is an important factor when choosing an inhaler device for asthma or chronic obstructive pulmonary disease (COPD). AIMS: To identify characteristics of patients with asthma or COPD who prefer a once-daily controller medication regimen. METHODS: This retrospective observational study used electronic patient records and linked outcomes from patient-completed questionnaires in a primary care database. We compared the characteristics of patients indicating a preference for once-daily therapy with those who were unsure or indicating no preference. RESULTS: Of 3,731 patients with asthma, 2,174 (58%) were women; the mean age was 46 years (range 2–94). Of 2,138 patients with COPD, 980 (46%) were women; the mean age was 70 years (range 35–98). Approximately half of the patients in each cohort indicated once-daily preference, one-quarter were unsure, and one-quarter did not prefer once-daily therapy. In patients with asthma or COPD, the preference for once-daily controller medication was significantly associated with poor adherence and higher concerns about medication. In asthma, good control and low self-perceived controller medication need were associated with once-daily preference. By contrast, in COPD, a high self-perceived need for controller medication was associated with once-daily preference. There was no significant relationship between once-daily preference and age, sex, disease severity, or exacerbation history. CONCLUSIONS: Understanding patient preferences may help prescribers to individualise therapy better for asthma and COPD.

Cite as: Price D, Lee AJ, Sims EJ, Kemp L, Hillyer EV, Chisholm A, von Ziegenweidt J, Williams A. Characteristics of patients preferring once-daily controller therapy for asthma and COPD: a retrospective cohort study. Prim Care Respir J 2013; Available from: URL: http://dx.doi.org/10.4104/pcrj.2013.00017

Keywords
adherence, asthma, chronic obstructive pulmonary disease, once-daily, preference, retrospective observational study

* Corresponding author. David Price Tel: +44 (0)1224 554588 Fax: +44 (0)1224 554588 Email: david@respiratoryresearch.org

© 2013 Primary Care Respiratory Society UK. All rights reserved.

	View full text as PDF document
	Right click on this DOI link and copy link/shortcut to cite this article (What is a DOI link?)
	Export to bibliographic software or plain text
	Post to CiteULike
	Email this article to friend/s or colleague/s