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Human dendritic cell subsets
DOI: 10.1111/imm.12117
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- This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an ‘Accepted Article’, doi: 10.1111/imm.12117
The orchestration of effective immunity in vertebrates depends upon dendritic cells (DCs), a class of bone marrow-derived cells found in the blood, epithelia and lymphoid tissues. DCs are equipped with molecular sensors and antigen processing machinery to recognise pathogens, integrate chemical information and to guide the specificity, magnitude and polarity of immune responses. Recent advances have helped to define DCs as a distinct haematopoietic lineage and to establish functional specialization between different DC subsets. The aim of this review is to present a coherent framework for understanding human DC subsets and their functional roles in vivo.
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