Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine

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|    Asia Pac Allergy. 2013 Apr;3(2):106-114. English. Published online 2013 April 26.  http://dx.doi.org/10.5415/apallergy.2013.3.2.106  Copyright © 2013. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine Naoyuki Inoue, and Asuka Yamamoto Department of Pediatrics, Inagi Municipal Hospital, 1171 Omaru, Inagi, Tokyo 206-2801, Japan.  Correspondence: Naoyuki Inoue. Department of Pediatrics, Inagi Municipal Hospital, 1171 Omaru, Inagi, Tokyo 206-2801, Japan. Tel: +81-42-377-0931, Fax: +81-42-377-1156, Email: nao2014272@yahoo.co.jp  Received January 08, 2013; Accepted March 25, 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Epinephrine administered intramuscularly is the treatment of choice for anaphylaxis, and more than 1 dose is occasionally required. Objective To determine clinical background of anaphylaxis for improving the treatment, management, and prognosis of anaphylaxis. Methods Children who had satisfied the diagnostic criteria for anaphylaxis according to the National Institute of Allergy and Infectious Disease Food Allergy and Anaphylaxis Network were selected from our hospital from April 1, 2009 to March 31, 2012. Results We analyzed 61 patients from the ages of 2 months to 14 years who satisfied the diagnostic criteria for anaphylaxis. Parents of 32 children (52.5%) reported that they had been administered single dose of epinephrine, and 3 children (4.9%) reported receiving multiple doses of epinephrine. The latter group experienced syncope more often (p = 0.049) than the former and suffered more often from comorbid allergic diseases (p = 0.043) that included either bronchial asthma, allergic rhinitis, or atopic dermatitis. Two (3.3%) children experienced biphasic reactions. Patients who experienced a biphasic reaction were more likely to have experienced syncope (p = 0.033), vomiting (p = 0.02), and administration of multiple doses of epinephrine (p = 0.0016). Conclusion Our findings lead us to recommend that children receiving more than 1 injection of epinephrine should be observed for 24 hours, because it seems that children with requiring more than 1 injection of epinephrine might be have biphasic reactions. Keywords: Epinephrine, Children, Biphasic anaphylaxis, Anaphylaxis.