- Allergy Rhinol (Providence)
- v.3(2); Fall 2012
- PMC3548612
Allergy Rhinol (Providence). 2012 Fall; 3(2): e74–e90.
Published online 2012 December 18. doi: 10.2500/ar.2012.3.0036
PMCID: PMC3548612
Rubaba Hamid Shafique, M.Phil,
1 Muhammad Inam, M.Phil,2 Muhammad Ismail, Ph.D.,3 and Farhana Riaz Chaudhary, Ph.D.1
Abstract
Group 10 allergens (tropomyosins) have been assumed to be a major cause of cross-reactivity between house-dust mites (HDMs) and other invertebrates. Despite all of the published data regarding the epidemiology, percent IgE binding and level of sensitization in the population, the role of tropomyosin as a cross-reactive allergen in patients with multiple allergy syndrome still remains to be elucidated. Homology between amino acid sequences reported in allergen databases of selected invertebrate tropomyosins was determined with Der f 10 as the reference allergen. The 66.9 and 54.4% identities were found with selected crustacean and insect species, respectively, whereas only 20.4% identity was seen with mollusks. A similar analysis was performed using reported B-cell IgE-binding epitopes from Met e1 (shrimp allergen) and Bla g7 (cockroach allergen) with other invertebrate tropomyosins. The percent identity in linear sequences was higher than 35% in mites, crustaceans, and cockroaches. The polar and hydrophobic regions in these groups were highly conserved. These findings suggest that tropomyosin may be a major cause of covariation of sensitization between HDMs, crustaceans, and some species of insects and mollusks.
Keywords: Cross-reactivity of tropomyosins, group 10 allergens, HDM allergens, homology, IgE-binding epitopes, multiple allergy syndrome, tropomyosins
No comments:
Post a Comment