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Article Citation:

Amir Behdad and Scott R. Owens (2013) Systemic Mastocytosis Involving the Gastrointestinal Tract: Case Report and Review. Archives of Pathology & Laboratory Medicine: September 2013, Vol. 137, No. 9, pp. 1220-1223.

doi: http://dx.doi.org/10.5858/arpa.2013-0271-CR

SPECIAL SECTION—2012 NEW FRONTIERS IN PATHOLOGY

Systemic Mastocytosis Involving the Gastrointestinal Tract: Case Report and Review

Amir Behdad , MD; Scott R. Owens , MD

From the Department of Pathology, University of Michigan, Ann Arbor.

Mastocytosis is rare, and is actually a heterogeneous group of diseases that may only involve the skin (urticaria pigmentosa) or that may have a systemic presentation with multiorgan involvement. The gastrointestinal (GI) tract can be affected and symptoms related to GI involvement are often nonspecific. The diagnosis of systemic mastocytosis with primarily GI presentation can be challenging and requires familiarity with this entity and a high index of suspicion. We report a case of systemic mastocytosis primarily diagnosed by the recognition of small intestinal and colonic involvement and review the diagnostic criteria, histopathology, and recent developments regarding this entity.

Accepted: May 20, 2013

The authors have no relevant financial interest in the products or companies described in this article.

Presented at the New Frontiers in Pathology: An Update for Practicing Pathologists meeting; Homestead Resort; August 3–5, 2012; Glen Arbor, Michigan.

Reprints: Scott R. Owens, MD, Department of Pathology, University of Michigan, 1301 E. Catherine St, 5224 MSI, Ann Arbor, MI 48109 (e-mail: srowens@med.umich.edu).