REVIEW ARTICLE
Front. Immunol., 18 October 2013 | doi: 10.3389/fimmu.2013.00337
Jielin Zhang- Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Recent studies have highlighted the importance of eradication of human immunodeficiency virus (HIV) and cure of acquired immunodeficiency syndrome (AIDS). However, a pivotal point that the patient immunity controls HIV reactivation after highly active anti-retroviral therapy [HAART or combination anti-retroviral therapy (cART)] remains less well addressed. In spite of the fact that both innate and adaptive immunities are indispensable and numerous cells participate in the anti-HIV immunity, memory CD4 T-cells are indisputably the key cells organizing all immune actions against HIV while being the targets of HIV. Here we present a view and multidisciplinary approaches to HIV/AIDS eradication and cure. We aim at memory CD4 T-cells, utilizing the stem cell properties of these cells to reprogram an anti-HIV memory repertoire to eliminate the viral reservoir, toward achieving an AIDS-free world.
Keywords: HIV, memory CD4 T-cells, P21Cip1, epigenetics, hematopoietic stem cells
Citation: Zhang J and Crumpacker C (2013) Eradication of HIV and cure of AIDS, now and how? Front. Immunol. 4:337. doi: 10.3389/fimmu.2013.00337
Received: 15 August 2013; Paper pending published: 10 September 2013;
Accepted: 03 October 2013; Published online: 18 October 2013.
Accepted: 03 October 2013; Published online: 18 October 2013.
Edited by:
Donald Sodora, Seattle Biomedical Research Institute, USA
Reviewed by:
Aurelio Cafaro, Istituto Superiore di Sanità , ItalyMarina Cella, Washington University, USA
Copyright: © 2013 Zhang and Crumpacker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Clyde Crumpacker, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA e-mail: ccrumpac@bidmc.harvard.edu
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