BioMed Research International
Volume 2013 (2013), Article ID 932391, 17 pages
http://dx.doi.org/10.1155/2013/932391
Review Article
1Department of Pediatrics, Division of Allergy and Immunology, Research and Training Hospital of Sakarya University, Faculty of Medicine, Sakarya University, Adnan Menderes Caddesi, Sağlık Sokak No. 195, Adapazarı, 54100 Sakarya, Turkey
2Department of Histology and Embryology, Faculty of Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey
2Department of Histology and Embryology, Faculty of Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey
Received 21 April 2013; Accepted 18 July 2013
Academic Editor: Ibrahim Banat
Copyright © 2013 Öner Özdemir and Azize Yasemin Göksu Erol. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Probiotics are ingested live microbes that can modify intestinal microbial populations in a way that benefits the host. The interest in probiotic preventative/therapeutic potential in allergic diseases stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines in human and murine experimental models. Enhanced presence of probiotic bacteria in the intestinal microbiota is found to correlate with protection against allergy. Therefore, many studies have been recently designed to examine the efficacy of probiotics, but the literature on the allergic skin disorders is still very scarce. Here, our objective is to summarize and evaluate the available knowledge from randomized or nonrandomized controlled trials of probiotic use in allergic skin conditions. Clinical improvement especially in IgE-sensitized eczema and experimental models such as atopic dermatitis-like lesions (trinitrochlorobenzene and picryl chloride sensitizations) and allergic contact dermatitis (dinitrofluorobenzene sensitization) has been reported. Although there is a very promising evidence to recommend the addition of probiotics into foods, probiotics do not have a proven role in the prevention or the therapy of allergic skin disorders. Thus, being aware of possible measures, such as probiotics use, to prevent/heal atopic diseases is essential for the practicing allergy specialist.
No comments:
Post a Comment