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Allergy Asthma Immunol Res. 2013 Nov;5(6):415-417. English.
Published online 2013 July 02. http://dx.doi.org/10.4168/aair.2013.5.6.415 |
| Copyright © 2013 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease |
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Parkpoom Phatharacharukul,1 and Jettanong Klaewsongkram 2 |
| 1Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. |
| 2Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Allergy and Clinical Immunolgy Research Group, Chulalongkorn University, Bangkok, Thailand. |
Correspondence to: Jettanong Klaewsongkram, MD, Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Allergy and Clinical Immunolgy Research Group, Chulalongkorn University, Bangkok 10330, Thailand. Tel: +662-2564152; Fax: +662-2542323; Email:Jettanong.K@chula.ac.th
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Received October 31, 2012; Accepted December 26, 2012.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
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A 24-year-old male with a history of spondyloarthropathy presented with high fever, cervical lymphadenopathy and generalized maculopapular rash. He was treated with prednisolone for chronic uveitis before being switched to sulfasalazine 3 weeks prior to admission. Laboratory findings revealed marked leukocytosis with frequent atypical lymphocytes. Sulfasalazine was discontinued and the etiology of mononucleosis syndrome explored. During admission, he developed acalculous cholecystitis and hypotension. All symptoms quickly improved following administration of systemic corticosteroids. The investigation for infectious mononucleosis yielded negative results and a diagnosis of sulfasalazine-induced hypersensitivity syndrome was confirmed using enzyme-linked immunospot assays.
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Keywords: Drug hypersensitivity, enzyme-linked immunospot assay, sulfasalazine.
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Open Access
Abstract
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