Extensive pulmonary alveolar microlithiasis

Case Report

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1. Nuttapol Rittayamai^1,*, 
2. Nisa Muangman²,
3. Ruchira Ruangchira-urai³

Article first published online: 28 NOV 2013 DOI: 10.1002/rcr2.30

© 2013 The Authors. Respirology Case Reportspublished by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Keywords:

• Alveolar microlithiasis;
• computed tomography of chest;
• hypoxemia;
• pulmonary calcification;
• SLC34A2 gene

Abstract

Pulmonary alveolar microlithiasis is a rare pulmonary disorder that is caused by abnormal sodium-dependent 

phosphate co-transporter from the mutation of SLC34A2 gene, leading to accumulation of microliths in the alveoli. We report the extensive pulmonary alveolar microlithiasis in an elderly woman who presented with progressive dyspnea for 2 months. Chest radiograph revealed diffuse pulmonary calcification. Tissue histopathology from open lung biopsy demonstrated widespread intra-alveolar laminated calcium deposits compatible with pulmonary alveolar microlithiasis.

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