Abstract
Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans.
Citation: Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, et al. (2013) IL-33, but Not IL-25, Is Crucial for the Development of House Dust Mite Antigen-Induced Allergic Rhinitis. PLoS ONE 8(10): e78099. doi:10.1371/journal.pone.0078099
Editor: Cordula M. Stover, University of Leicester, United Kingdom
Received: July 10, 2013; Accepted: September 7, 2013; Published: October 25, 2013
Copyright: © 2013 Nakanishi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by the Global COE Program, “Center of Education and Research for Advanced Genome-Based Medicine-For Personalized medicine and the control of worldwide infectious disease,” from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) (WN), Grants-in-Aid for Young Scientists (A), MEXT (SN), Health Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare, Japan (HS and KM), The Grant of National Center for Child Health and Development (23A-5) (KM), and Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency (SN). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist
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