Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There has been a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain.
Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphoma, and systemic diseases such as kidney and liver disease and cancer.
Composed of contributions from distinguished researchers around the world, the book explores topics such as
- Neuropathic itch
- Peripheral neuronal mechanism of itch
- The role of PAR-2 in neuroimmune communication and itch
- Mrgprs as itch receptors
- The role of interleukin-31 and oncostatin M in itch and neuroimmune communication
- Spinal coding of itch and pain
- Spinal microcircuits and the regulation of itch
Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Contents
- Series Preface
- Preface
- Editors
- Contributors
- 1. Itch Hypotheses: From Pattern to Specificity and to Population CodingHermann O Handwerker.
- 2. Epidemiology of ItchElke Weisshaar and Uwe Matterne.
- 3. Atopic DermatitisUlf Darsow, Ulrike Raap, and Sonja Ständer.
- 4. Clinical Aspects of Itch: PsoriasisAdam Reich and Jacek C Szepietowski.
- 5. Pruritus in Renal DiseaseThomas Mettang.
- 6. Pruritus of CholestasisNora V Bergasa.
- 7. Neuropathic ItchAnne Louise Oaklander.
- 8. Pruritus in Cutaneous T-Cell LymphomasLaurent Misery.
- 9. PruriceptorsMatthias Ringkamp and Richard Meyer.
- 10. Peripheral Neuronal Mechanism of Itch: Histamine and ItchRobin L Thurmond, Kayvan Kazerouni, Sandra R Chaplan, and Andrew J Greenspan.
- 11. Role of PAR-2 in Neuroimmune Communication and ItchCordula Kempkes, Joerg Buddenkotte, Ferda Cevikbas, Timo Buhl, and Martin Steinhoff.
- 12. Mrgprs as Itch ReceptorsBenjamin McNeil and Xinzhong Dong.
- 13. Role of Interleukin-31 and Oncostatin M in Itch and Neuroimmune CommunicationFerda Cevikbas, Cordula Kempkes, Timo Buhl, Christian Mess, Joerg Buddenkotte, and Martin Steinhoff.
- 14. Toll-Like Receptors and ItchTong Liu and Ru-Rong Ji.
- 15. Lipid Mediators and ItchTsugunobu Andoh and Yasushi Kuraishi.
- 16. Role of Transient Receptor Potential Channels in Acute and Chronic ItchSarah R Wilson and Diana M Bautista.
- 17. Sensitization of Itch Signaling: Itch Sensitization—Nerve Growth Factor, SemaphorinsMitsutoshi Tominaga and Kenji Takamori.
- 18. Peripheral OpioidsPaul L Bigliardi and Mei Bigliardi-Qi.
- 19. Spinal Coding of Itch and PainTasuku Akiyama and E Carstens.
- 20. Spinal Microcircuits and the Regulation of ItchSarah E Ross, Junichi Hachisuka, and Andrew J Todd.
- 21. Itch Modulation by VGLUT2-Dependent Glutamate Release from Somatic Sensory NeuronsQiufu Ma.
- 22. Ascending Pathways for ItchSteve Davidson, Hannah Moser, and Glenn Giesler.
- 23. Brain Processing of Itch and ScratchingHideki Mochizuki, Alexandru D.P Papoiu, and Gil Yosipovitch.
- 24. Central Nervous Processing of Itch and PainClemens Forster and Hermann O Handwerker.
- 25. Roles of Central Opioid Receptor Subtypes in Regulating Itch SensationMei-Chuan Ko.
- 26. Sensitization for ItchMartin Schmelz.
Bookshelf ID: NBK200931PMID: 24830003
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