Chronic urticaria as the first sign of sarcoidosis

1. Canadian Family Physician June 2014 vol. 60 no. 6546-547

María Socorro Pérez Bustamante, MD

1. Physician, the Servicio de Enfermedades del Sistema Inmune-Alergia at the Hospital Universitario Príncipe de Asturias in Alcalá de Henares, and in the Departamento de Medicina at the Universidad de Alcalá in Madrid, Spain.

1. Jose Barbarroja Escudero, MD PhD

1. Honorary Professor, the Servicio de Enfermedades del Sistema Inmune-Alergia at the Hospital Universitario Príncipe de Asturias in Alcalá de Henares, and in the Departamento de Medicina at the Universidad de Alcalá in Madrid, Spain.

1. Darío Antolín-Amérigo, MD PhD⇑

1. Honorary Professor, the Servicio de Enfermedades del Sistema Inmune-Alergia at the Hospital Universitario Príncipe de Asturias in Alcalá de Henares, and in the Departamento de Medicina at the Universidad de Alcalá in Madrid, Spain.

1. Correspondence: Dr Darío Antolín-Amérigo, Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Carretera de Alcalá-meco s/n, 28805, Alcalá de Henares, Madrid, Spain; telephone +34 91-8878100, extension 2165; fax +34 91-8801825; e-maildario.antolin@gmail.com

1. María José Sánchez-González, MD

1. Physician, the Servicio de Enfermedades del Sistema Inmune-Alergia at the Hospital Universitario Príncipe de Asturias in Alcalá de Henares, and in the Departamento de Medicina at the Universidad de Alcalá in Madrid, Spain.

1. Mercedes Rodríguez-Rodríguez, MD

1. Honorary Professor, the Servicio de Enfermedades del Sistema Inmune-Alergia at the Hospital Universitario Príncipe de Asturias in Alcalá de Henares, and in the Departamento de Medicina at the Universidad de Alcalá in Madrid, Spain.

1. Melchor Alvarez-Mon, MD PhD

+Author Affiliations

1. Head and Professor, the Servicio de Enfermedades del Sistema Inmune-Alergia at the Hospital Universitario Príncipe de Asturias in Alcalá de Henares, and in the Departamento de Medicina at the Universidad de Alcalá in Madrid, Spain.

Sarcoidosis is a granulomatous multisystem disease of unclear pathogenesis that can affect any organ.1 The cutaneous manifestations are present in 20% to 35% of patients. Skin lesions are classified as specific or nonspecific depending on the presence of noncaseating granulomas on histologic studies. Specific lesions include maculopapules, plaques, nodules, lupus pernio, scar infiltration, alopecia, ulcerative lesions, and hypopigmentation, among other types of lesions. The most common nonspecific lesion is erythema nodosum. Other infrequent cutaneous manifestations include calcifications, prurigo, erythema multiforme, nail clubbing, and acute febrile neutrophilic dermatosis.2 We report a case of chronic urticaria of unknown cause that, after 6 months of treatment with antihistamines, displayed symptoms consistent with respiratory disease associated with systemic involvement.

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