BioMed Research International
Volume 2013 (2013), Article ID 707856, 8 pages
http://dx.doi.org/10.1155/2013/707856
Clinical Study
1Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France
2Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France
3Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France
4Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
2Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France
3Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France
4Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Received 29 April 2013; Revised 9 July 2013; Accepted 23 July 2013
Academic Editor: Salvatore Battaglia
Copyright © 2013 Grégory Marin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background. Asthma-like symptoms are frequent in overweight and obesity, but the mechanism is unclear when airway hyperresponsiveness (AHR) is lacking. In this study, we focused on obese women with a clinical suspicion of asthma but negative methacholine challenge and tested distal airway hyperreactivity, explored by Forced Vital Capacity dose-response slope (FVC DRS). Objective. To question AHR at the distal airway level in obese women. Methods. A total of 293 symptomatic obese and nonobese women free of treatment were investigated. Methacholine challenge tests were undertaken, and patients were divided according to their results to the test. In hyperreactive and nonhyperreactive patients and in our total population, correlations, regression analyses, and analyses of covariance were performed to compare distal airway hyperreactivity in three groups of body mass index (BMI). Results. After adjusting for age and baseline respiratory values, the relationship between FVC and FEV1 (forced expiratory volume in one second) DRS was influenced by BMI, with a lower slope in obese than overweight and normal patients in our total population () and in our nonhyperreactive one (). Conclusion. Distal airway hyperresponsiveness was observed in symptomatic wheezing obese women negative to methacholine challenge.
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