A laboratory test based on determination of cytokine profiles: a promising assay to identify exposition to contact allergens and predict the clinical outcome in occupational allergic contact dermatitis

Methodology article

Valentina Bordignon^1*, Francesca Palamara², Giorgia Altomonte², Isabella Sperduti³, Mario Pietravalle¹, Claudia Cavallotti⁴, Paola Cordiali-Fei¹, Maria Pia Fuggetta⁵, Antonio Cristaudo² and Fabrizio Ensoli¹

BMC Immunology 2015, 16:4  doi:10.1186/s12865-015-0066-3

Abstract

Background

Para-phenylenediamine (PPD) is the main allergen causing adverse reactions to hair dyes and a frequent cause of occupational-related skin sensitization among hairdressers and beauticians. The immunologic mechanism of the disease relies on the production of inflammatory cytokines by allergen-specific T cells, while regulatory T cells are thought to down-modulate the allergic response. This study was aimed at investigating the expression of effector or regulatory cytokines in exposed subjects in order to verify whether different cytokine profiles might predict distinct clinical outcomes.

Latest Article Alert from World Allergy Organization Journal

The following new articles have just been published in World Allergy Organization Journal For articles using Author Version-first publication you will see a provisional PDF corresponding to the accepted manuscript. In these instances, the fully formatted Final Version PDF and full text (HTML) versions will follow in due course.

The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies

Review

Satoru Mihara¹ and Takayuki Shibamoto^2*

Allergy, Asthma & Clinical Immunology 2015, 11:11  doi:10.1186/s13223-015-0074-0

Abstract (provisional)

TRPA1 has been proposed to be associated with diverse sensory allergic reactions, including thermal (cold) nociception, hearing and allergic inflammatory conditions. Some naturally occurring compounds are known to activate TRPA1 by forming a Michael addition product with a cysteine residue of TRPA1 through covalent protein modification and, in consequence, to cause allergic reactions. The anti-allergic property of TRPA1 agonists may be due to the activation and subsequent desensitization of TRPA1 expressed in sensory neurons. In this review, naturally occurring TRPA1 antagonists, such as camphor, 1,8-cineole, menthol, borneol, fenchyl alcohol and 2-methylisoborneol, and TRPA1 agonists, including thymol, carvacrol, 1’S-1’- acetoxychavicol acetate, cinnamaldehyde, α-n-hexyl cinnamic aldehyde and thymoquinone as well as isothiocyanates and sulfides are discussed.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Allergy to cooked, but not raw, peas: a case series and review

Case report

Published: 15 March 2015
 

Elissa M Abrams^* and Thomas V Gerstner

Allergy, Asthma & Clinical Immunology 2015, 11:10  doi:10.1186/s13223-015-0077-x

Abstract

Allergic reactions to legumes are common.Food allergy to cooked, but not raw, pea has been rarely reported in the literature. This case series describes five children who had various IgE-mediated symptoms upon consumption of cooked pea, but tolerated raw pea. Skin testing then confirmed positive responses to cooked, but not raw, peas. It is important to consider allergy to cooked legumes, even in the context of raw legume tolerance.

Keywords:Food allergy; Pea; Legume 

Viewing options

• Full text
• PDF(303KB)
• Additional files

Single NSAID hypersensitivity is associated with atopic status

Volume 47 n. 2/2015  March 2015

R. Asero
Background: The relationship between hypersensitivity to NSAID and atopic status is still incompletely defined. Previous studies found a high prevalence of atopic diseases in multiple NSAID reactors. The present study aimed to investigate whether this is the case also in Italian adults hypersensitive to NSAIDs. Methods: Skin tests with a large panel of seasonal and perennial airborne allergens were carried out in 252 patients with a clear-cut history of acute urticaria induced by nonsteroidal anti-inflammatory drugs. Patients were classified as single or multiple NSAID reactors based on clinical history, presence/absence of chronic urticaria, re-challenge with the reported offending drug in case of doubt history, and oral challenges with aspirin or propionic acid derivatives. Results: Single NSAID reactors showed a much higher prevalence of atopic diseases than multiple NSAID reactors either with or without chronic urticaria (61% vs 19% and 19%, respectively; p < 0.001). Conclusion: As a difference from previous reports, in Italian patients hypersensitive to NSAID atopy is much more prevalent among single reactors, a finding that indirectly supports the possible IgE-mediated origin of this type of adverse drug reaction.

 FULL TEXT

The long-acting β2-agonist olodaterol attenuates pulmonary inflammation

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future) 

British Journal of Pharmacology

1. Eva Wex^1,*, 
2. Ines Kollak¹, 
3. Matthias J Duechs¹, 
4. Emmanuel Naline², 
5. Lutz Wollin¹and
6. Philippe Devillier²
DOI: 10.1111/bph.13143

Abstract
Background and purpose

β₂-agonists are widely used in the management of obstructive airway diseases. Besides their bronchodilatory effect several studies suggest inhibitory effects on various aspects of inflammation. The aim of our study was to determine the efficacy of the long-acting β₂-agonist olodaterol to inhibit pulmonary inflammation and to shed light on its anti-inflammatory mechanism of action.

CSACI position statement: systemic effect of inhaled corticosteroids on adrenal suppression in the management of pediatric asthma

Position article and guidelines

Karine Issa-El-Khoury¹, Harold Kim²³, Edmond S Chan⁴, Tim Vander Leek⁵ and Francisco Noya^1*

Allergy, Asthma & Clinical Immunology 2015, 11:9  doi:10.1186/s13223-015-0075-z

Abstract

Asthma is a chronic inflammatory disease of the airways that affects a growing number of children and adolescents. Inhaled corticosteroids (ICS) are the mainstay of treatment in persistent asthma, with a stepwise approach to increasing doses of ICS depending on asthma severity and control. ICS have known local and systemic side effects, of which adrenal suppression is still under-recognized.

Abstracts from the 2nd International Severe Asthma Forum (ISAF) -Athens, Greece 13-15 November 2014

Meeting abstracts

2nd International Severe Asthma Forum (ISAF)

Athens, Greece

13-15 November 2014

Publication charges for this supplement were funded by The European Academy of Allergy and Clinical Immunology (EAACI).

Conference website

Clinical and Translational Allergy publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 5 Supplement 2

Oral presentation    Th2-high asthma: a heterogeneous asthma population? Seys Sven, Hans Scheers, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter Goeminne, Paul Van den Brande, Jan Ceuppens, Lieven Dupont, Dominique BullensClinical and Translational Allergy 2015, 5(Suppl 2):O1 (23 March 2015) Full text | PDF

Oral presentation    Phenotyping asthma using an unsupervised prediction model based on blood granulocyte responsiveness Bart Hilvering, Susanne Vijverberg, Jeroen Jansen, Leo Houben, Rene Schweizer, Jan-Willem Lammers, Leo KoendermanClinical and Translational Allergy 2015, 5(Suppl 2):O2 (23 March 2015) Full text | PDF

World Allergy Week 2015 - Slide Set Presentation

World Allergy Week 2015: AIRWAY ALLERGIES The human and economic burden 

Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance

PLoS Genet. 2015 Mar; 11(3): e1005076.

Published online 2015 Mar 10. doi:  10.1371/journal.pgen.1005076

PMCID: PMC4355615

Jorge Esparza-Gordillo,1,2 Anja Matanovic,1,2 Ingo Marenholz,1,2 Anja Bauerfeind,1 Klaus Rohde,1 Katja Nemat,3 Min-Ae Lee-Kirsch,3 Magnus Nordenskjöld,4 Marten C. G. Winge,4 Thomas Keil,5 Renate Krüger,6 Susanne Lau,6 Kirsten Beyer,6 Birgit Kalb,6 Bodo Niggemann,6 Norbert Hübner,1 Heather J. Cordell,7 Maria Bradley,4,8 and Young-Ae Lee1,2,*

Author information ► Article notes ► Copyright and License information ►

Abstract

Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or due to maternal effects reflecting the maternal genome's influence on the child during prenatal development.

Effect of breastfeeding on lung function in asthmatic children

• Allergy and Asthma Proceedings
• Volume 36, Issue 2, pages 116-122

Hwan Soo Kim, M.D.1; Yoon Hee Kim, M.D.2; Min Jung Kim, M.D.2; Hee Seon Lee, M.D.2; Yoon Ki Han, M.D.2; Kyung Won Kim, M.D., Ph.D.2; Myung Hyun Sohn, M.D., Ph.D.2; Kyu-Earn Kim, M.D., Ph.D.2

From the ¹Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea, and ²Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

Address correspondence to Kyung Won Kim, M.D., Ph.D., Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail address: kwkim@yuhs.ac

ABSTRACT

Effect of breastfeeding on the protective effect on asthma has been studied extensively but remains controversial. Studies regarding the effect of breastfeeding on lung function have also been conflicting. The aim of this study was to determine the influence of breastfeeding on lung function in asthmatic children. We included 555 patients who visited Severance Children's Hospital Allergy Clinic with asthma.

A practical approach to vitamin and mineral supplementation in food allergic children

Research

Rosan Meyer^1*, Claire De Koker², Robert Dziubak¹, Ana-Kristina Skrapac², Heather Godwin¹, Kate Reeve¹, Adriana Chebar-Lozinsky¹ and Neil Shah¹³Clinical and Translational Allergy 2015, 5:11  doi:10.1186/s13601-015-0054-y

Abstract (provisional)

Background The management of food allergy in children requires elimination of the offending allergens, which significantly contribute to micronutrient intake. Vitamin and mineral supplementation are commonly suggested as part of dietary management.

Chronic urticaria in adults: state-of-the-art in the new millennium

• An Bras Dermatol
• v.90(1); Jan-Feb 2015
• PMC4323701

An Bras Dermatol. 2015 Jan-Feb; 90(1): 74–89.

doi:  10.1590/abd1806-4841.20153509

Paulo Ricardo Criado,1 Roberta Facchini Jardim Criado,2 Celina Wakisaka Maruta,1 and Vitor Manoel Silva dos Reis1Author information ► Article notes ► Copyright and License information ►
Keywords: Angioedema, Biological factors, Colchicine, Cyclosporine, Dapsone, Immunosuppressive agents, Urticaria

Abstract

Chronic urticaria has been explored in several investigative aspects in the new millennium, either as to its pathogenesis, its stand as an autoimmune or auto-reactive disease, the correlation with HLA-linked genetic factors, especially with class II or its interrelation with the coagulation and fibrinolysis systems.