Immunoregulatory T cell epitope peptides: the new frontier in allergy therapy

• Volume 45, Issue 6
  June 2015 
  Pages 1015–1026Creative Commons
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State of the Art Reviews on Mechanisms of Allergic Disease

Authors

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DOI: 10.1111/cea.12554View/save citation
Summary
Allergen immunotherapy (AIT) has been practised since 1911 and remains the only therapy proven to modify the natural history of allergic diseases. Although efficacious in carefully selected individuals, the currently licensed whole allergen extracts retain the risk of IgE-mediated adverse events, including anaphylaxis and occasionally death. This together with the need for prolonged treatment regimens results in poor patient adherence. 

GINA Report, Global Strategy for Asthma Management and Prevention

Updated April 2015

Please reference this document as follows: From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2015. Available from: http://www.ginasthma.org/.

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Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study

Yu Okada

,

 Noriyuki Yanagida

,

 Sakura Sato

,

 Motohiro Ebisawa

Publication stage: In Press Corrected Proof

Open Access

DOI: http://dx.doi.org/10.1016/j.alit.2015.04.002

Open access funded by Japanese Society of Allergology

Article Info

• Abstract
• Full Text
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Abstract

Background

Low dose reactive cow's milk (CM) allergic children are at high risk of persistent CM allergy and a positive oral food challenge (OFC). The present study aimed to evaluate if the results of a very low dose (VL) OFC with these children contributes to better management of CM allergy.

Antibiotics in the first week of life is a risk factor for allergic rhinitis at school age

• Wiley-Blackwell Online Open
• PMC4282316

Pediatric Allergy and Immunology

Wiley-Blackwell, John Wiley & Sons

Pediatr Allergy Immunol. 2014 Aug; 25(5): 468–472.

Bernt Alm,1 Emma Goksör, Rolf Pettersson, Per Möllborg, Laslo Erdes, Petra Loid, Nils Åberg, and Göran Wennergren

Author information ► Article notes ► Copyright and License information ►

Abstract

Background

Heredity as well as external factors influences the development of allergic rhinitis. The aim of this study was to analyse early risk factors and protective factors for allergic rhinitis at school age.

Type-2 innate lymphoid cells in human allergic disease

• Lippincott Williams & Wilkins Open Access
• PMC4154789

Current Opinion in Allergy and Clinical Immunology

Curr Opin Allergy Clin Immunol. 2014 Oct; 14(5): 397–403.28. doi:  10.1097/ACI.0000000000000090
Jillian L. Barlow and Andrew N.J. McKenzieAuthor information ► Copyright and License information ►

Abstract

Purpose of review

Recent decades have seen allergic diseases become endemic in a number of developed countries. Understanding the inflammatory processes that dictate these allergic responses is therefore important.

Physical training for asthma

Sao Paulo Medical Journal

Sao Paulo Med. J. vol.132 no.3 São Paulo  2014

http://dx.doi.org/10.1590/1516-3180.20141323T1 

COCHRANE HIGHLIGHTS

Kristin V. Carson, Madhu G. Chandratilleke, Joanna Picot, Malcom P. Brinn, Adrian J. Esterman A., Brian J. Smith

ABSTRACT

BACKGROUND:

People with asthma may show less tolerance to exercise due to worsening asthma symptoms during exercise or other reasons such as deconditioning as a consequence of inactivity. Some may restrict activities as per medical advice or family influence and this might result in reduced physical fitness. Physical training programs aim to improve physical fitness, neuromuscular coordination and self confidence. Subjectively, many people with asthma report that they are symptomatically better when fit, but results from trials have varied and have been difficult to compare because of different designs and training protocols. Also, as exercise can induce asthma, the safety of exercise programmes needs to be considered.

Prescribing of long-acting beta-2-agonists/inhaled corticosteroids after the SMART trial

Research article

Marietta Rottenkolber^1*, Rainald Fischer², Luisa Ibáñez³⁴, Joan Fortuny⁵, Robert Reynolds⁶, Justyna Amelio⁷, Roman Gerlach⁸, Martin Tauscher⁸, Petra Thürmann¹⁰⁹, Joerg Hasford¹ and Sven Schmiedl¹⁰⁹

BMC Pulmonary Medicine 2015, 15:55  doi:10.1186/s12890-015-0051-x

Abstract

Background

After the SMART trial evaluating the safety of salmeterol (long-acting beta-2-agonist (LABA)) in asthma patients, regulatory actions were taken to promote a guideline-adherent prescribing of LABA only to patients receiving inhaled corticosteroids (ICS). We aim to analyse LABA- and ICS-related prescription patterns after the SMART trial in Germany.

The effect of a new communication template on anticipated willingness to initiate or resume allergen immunotherapy: an internet-based patient survey

Moises A. Calderon^1*, Linda Cox², Thomas B. Casale³, Ralph Mösges⁴, Oliver Pfaar⁵⁶, Hans-Jørgen Malling⁷, Joaquin Sastre⁸, Musa Khaitov⁹ and Pascal Demoly¹⁰¹¹

Allergy, Asthma & Clinical Immunology 2015, 11:17  doi:10.1186/s13223-015-0083-z

Abstract (provisional)

Background A patient’s knowledge of his/her allergic condition and treatment is a key factor in adherence and effectiveness. 

Methods To assess patients’ understanding of allergy and acceptance of allergen immunotherapy on the basis of (i) information given by their physician at the time of prescription and (ii) a new communication template viewed some months later, we performed an Internet-based survey of patient panels in France, Germany, Spain, the USA and Russia.

Nitration of β-Lactoglobulin but Not of Ovomucoid Enhances Anaphylactic Responses in Food Allergic Mice.

Diesner SC1, Schultz C2, Ackaert C3, Oostingh GJ4, Ondracek A2, Stremnitzer C2, Singer J2, Heiden D2, Roth-Walter F5, Fazekas J2, Assmann VE2, Jensen-Jarolim E5, Stutz H3, Duschl A3, Untersmayr E2.

Author information

Abstract

BACKGROUND:

We revealed in previous studies that nitration of food proteins reduces the risk of de novo sensitization in a murine food allergy model. In contrast, in situations with preformed specific IgE antibodies, in vitro experiments suggested an increased capacity of effector cell activation by nitrated food proteins.

OBJECTIVE:

The aim of this study was to investigate the influence of protein nitration on the effector phase of food allergy.

Mites and other indoor allergens — from exposure to sensitization and treatment

Prof. Dr. Monika Raulf, 

K. C. Bergmann, 

S. Kull, 

I. Sander, 

Ch. Hilger, 

T. Brüning, 

U. Jappe, 

H. Müsken, 

A. Sperl, 

S. Vrtala, 

… show all 12A

Abstract:

House dust mites, cats and dogs are amongst the most frequent sources of indoor allergens in Europe. The fact that the allergens of house dust mites cause allergic disease through inhalation of house dust was discovered in 1964. The diagnosis of mite allergy is regularly complicated by its often nonspecific symptoms, which frequently develop insidiously and by no means always include attacks of paroxysmal sneezing and itching.

Effect of chemical modifications on allergenic potency of peanut proteins

Allergy and Asthma Proceedings, Volume 36, Number 3, May/June 2015, pp. 185-191(7) Authors: Bencharitiwong, Ramon; van der Kleij, Hanneke P.M.; Koppelman, Stef J.; Nowak-Węgrzyn, Anna

Background: 
Modification of native peanut extracts could reduce adverse effects of peanut immunotherapy. 

Sleep-disordered breathing and asthma: evidence from a large multicentric epidemiological study in China

Research

Liwen Li¹², Zhiwei Xu³, Xingming Jin⁴, Chonghuai Yan¹, Fan Jiang⁴, Shilu Tong³, Xiaoming Shen^5* and Shenghui Li^25*

Respiratory Research 2015, 16:56  doi:10.1186/s12931-015-0215-5

Published: 10 May 2015

Abstract (provisional)

Background Previous studies have postulated that sleep-disordered breathing (SDB) may be associated with the occurrence and exacerbation of asthma. However, there was limited quantitative evidence on the topic. This study aimed at investigating the prevalence and predisposing factors of asthma, and quantifying the association between SDB and asthma among school-aged children in China.

Eucalyptus Pollen Allergy and Asthma in Children: A Cross-Sectional Study in South-East Queensland, Australia

• PLoS One
• v.10(5); 2015
• PMC4418722

PLoS One. 2015; 10(5): e0126506.

Published online 2015 May 4. doi:  10.1371/journal.pone.0126506

PMCID: PMC4418722

Jane E. M. Gibbs*

Kazuhiro Ito, Academic Editor

Abstract

Objectives

To investigate Eucalyptus (gum tree) pollen allergy in children in relation to geography, particularly vegetation, and its relationship to asthma.