CSACI position statement: epinephrine auto-injectors and children less than 15 kg

Michelle Halbrich^1*, Douglas P. Mack², Stuart Carr³, Wade Watson⁴ and Harold Kim⁵⁶

Allergy, Asthma & Clinical Immunology 2015, 11:20  doi:10.1186/s13223-015-0086-9

Abstract (provisional)

Epinephrine (adrenaline) is the treatment of choice for anaphylaxis. While other medications, including H1-antihistamines, H2-antihistamines, corticosteroids, and inhaled beta-2 agonists are often used to treat anaphylaxis in the emergency setting, none of these medications has been shown to reverse anaphylaxis. Fatal anaphylaxis is related to the delayed use of epinephrine. In community settings, epinephrine is available as an auto-injector in two doses, 0.15 mg and 0.3 mg.

Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects

	Yonsei Med J > v.56(4); Jul 2015 Review Article  Open Access
	Jong-Uk Lee,1 Jeong Dong Kim,1 and Choon-Sik Park2 1Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Korea. 2Genome Research Center and Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.  Corresponding author: Dr. Choon-Sik Park, Genome Research Center and Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea. Tel: 82-32-621-5105, Fax: 82-32-621-5023, Email: mdcspark@daum.net  Abstract Over the past three decades, a large number of genetic studies have been aimed at finding genetic variants associated with the risk of asthma, applying various genetic and genomic approaches including linkage analysis, candidate gene polymorphism studies, and genome-wide association studies (GWAS). However, contrary to general expectation, even single nucleotide polymorphisms (SNPs) discovered by GWAS failed to fully explain the heritability of asthma.

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies

Thorax doi:10.1136/thoraxjnl-2014-206719

• Original article
• Nicola A Hanania1, 
• Michael Noonan2, 
• Jonathan Corren3, 
• Phillip Korenblat4, 
• Yanan Zheng5,
• Saloumeh K Fischer5, 
• Melissa Cheu5, 
• Wendy S Putnam5, 
• Elaine Murray5,
• Heleen Scheerens5, 
• Cecile TJ Holweg5, 
• Romeo Maciuca5, 
• Sarah Gray5, 
• Ramona Doyle5,
• Dana McClintock5, 
• Julie Olsson5, 
• John G Matthews5, 
• Karl Yen5

Abstract

Introduction In a subset of patients with asthma, standard-of-care treatment does not achieve disease control, highlighting the need for novel therapeutic approaches. Lebrikizumab is a humanised, monoclonal antibody that binds to and blocks interleukin-13 activity.

An individualized diagnostic approach based on guidelines for chronic urticaria (CU)

Journal of the European Academy of Dermatology and Venereology

Special Issue: An Overview of the Current Knowledge in Urticaria. Proceedings from the Global Urticaria Forum, November 2014, Prague, Czech Republic

Volume 29, Issue Supplement S3, pages 3–11, June 2015

1. A.M. Giménez-Arnau¹, 
2. C. Grattan², 
3. T. Zuberbier³ and
4. E. Toubi⁴ 

5. 
   

6. Abstract
   Chronic urticaria (CU), defined as the spontaneous or inducible appearance of hives, angioedema or both for 6 weeks or more, presents with a number of subtypes which all substantially impair patients’ quality of life (QoL).

Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

Research

Matt J Silver^12†, Noah J Kessler^3†, Branwen J Hennig¹², Paula Dominguez-Salas⁴⁵, Eleonora Laritsky³, Maria S Baker³, Cristian Coarfa⁶, Hector Hernandez-Vargas⁷, Jovita M Castelino⁸, Michael N Routledge⁸, Yun Yun Gong⁹,Zdenko Herceg⁷, Yong Sun Lee¹⁰, Kwanbok Lee¹⁰, Sophie E Moore¹¹¹², Anthony J Fulford¹², Andrew M Prentice^12*and Robert A Waterland^123*

Genome Biology 2015, 16:118  doi:10.1186/s13059-015-0660-y

Abstract

Background

Interindividual epigenetic variation that occurs systemically must be established prior to gastrulation in the very early embryo and, because it is systemic, can be assessed in easily biopsiable tissues. We employ two independent genome-wide approaches to search for such variants.

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

NATURE COMMUNICATIONS | ARTICLE    OPEN

Paula Dominguez-Salas,    Sophie E. Moore,    Maria S. Baker,    Andrew W. Bergen,    Sharon E. Cox,    Roger A. Dyer,    Anthony J. Fulford,    Yongtao Guan,    Eleonora Laritsky,    Matt J. Silver, Gary E. Swan,    Steven H. Zeisel,    Sheila M. Innis,    Robert A. Waterland,    Andrew M. Prentice    & Branwen J. Hennig

Nature Communications 5, Article number: 3746 doi:10.1038/ncomms4746

Abstract

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences.

Asthma Research and Practice

The following new articles have just been published in Asthma Research and Practice For articles using Author Version-first publication you will see a provisional PDF corresponding to the accepted manuscript. In these instances, the fully formatted Final Version PDF and full text (HTML) versions will follow in due course.

Editorial    Asthma research and practice: a new journey begins Celedon J, Passalacqua G, Canonica G Asthma Research and Practice 2015, 1 :5 (4 June 2015) Abstract | Full Text | PDF

Small-particle Inhaled Corticosteroid as First-line or Step-up Controller Therapy in Childhood Asthma

Article in Press

Willem M.C. van Aalderen, MD, PhD

,

 Jonathan Grigg, MD

,

 Theresa W. Guilbert, MD, MS

,

 Nicolas Roche, MD, PhD

,

Elliot Israel, MD

,

 Richard J. Martin, MD

,

 Gene Colice, MD

,

 Dirkje S. Postma, MD, PhD

,

 Elizabeth V. Hillyer, DVM

,

 Anne Burden, MSc

,

 Victoria Thomas, MSc

,

 Julie von Ziegenweidt

,

 David Price, FRCGP

Publication stage: In Press Corrected Proof

Open Access

DOI: http://dx.doi.org/10.1016/j.jaip.2015.04.012

Open access funded by the Author(s)

Article Info

• Abstract
• Full Text
• Images
• References
• Supplemental Materials

Background

Because randomized controlled trials of established pediatric asthma therapies are expensive and difficult to perform, observational studies may fill gaps in the evidence base.

Objectives

To compare the effectiveness of representative small-particle inhaled corticosteroid (ICS) with that of standard size–particle ICS for children initiating or stepping up ICS therapy for asthma (analysis 1) and to compare the effectiveness of ICS dose step-up using small-particle ICS with adding long-acting β2-agonist (LABA) to the ICS (analysis 2).

Allergic Diseases - New Insights. Open access book

Medicine

Edited by Celso Pereira , ISBN 978-953-51-2044-5, 244 pages, Publisher: InTech, Chapters published April 22, 2015 under CC BY 3.0 license
DOI: 10.5772/58513

Allergic diseases are one of the most prevalent diseases in the present with an undeniable correlation with development conditions and with the surrounding environment. Thus, it becomes imperative that the gradual understanding of the pathophysiology and treatment strategies may be convenient for wide dissemination in the scientific community. The chapters included in the book Allergic diseases New Insights addressed a variety of important topics related to distinct aspects related to allergy. The contribution of outstanding expert authors from many countries provided update reviews on basic, clinical and treatment aspects and put in evidence further research regarding the knowledge of immune system responses and key points of allergic inflammatory reactions.