H1-antihistamines for primary mast cell activation syndromes (MCAS): a systematic review

1. 1. 
      
2. Ulugbek B. Nurmatov^1,*, 
3. Edmund Rhatigan², 
4. F. Estelle R. Simons³ and
5. Aziz Sheikh^1,4

7. Allergy

   Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) doi: 10.1111/all.12672

Abstract

Background

Primary mast cell activation syndromes (MCAS) are a group of disorders presenting with symptoms of mast cell mediator release.

Objectives

To assess the effectiveness and safety of orally-administered H₁-antihistamines in the treatment of primary MCAS compared with placebo and other pharmacologic treatments.

Risk of Obstructive Sleep Apnea in Adult Patients with Asthma: A Population-Based Cohort Study in Taiwan

OPEN ACCESS

 

PEER-REVIEWED

RESEARCH ARTICLE

• Te-Chun Shen,
• Cheng-Li Lin,
• Chang-Ching Wei,
• Chia-Hung Chen,
• Chih-Yen Tu,
• Te-Chun Hsia,
• Chuen-Ming Shih,
• Wu-Huei Hsu,
• Fung-Chang Sung,
• Chia-Hung Kao 

• Published: June 11, 2015 DOI: 10.1371/journal.pone.0128461







Abstract
Background


There are several publications reported that obstructive sleep apnea (OSA) was associated with asthma. However, large-scaled, population-based cohort study has been limited. We aimed to examine the risk of OSA among adult patients with asthma in an Asian population.

EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders

1. O. Boyman^1,*, 
2. C. Kaegi¹, 
3. M. Akdis^2,3, 
4. S. Bavbek⁴, 
5. A. Bossios⁵, 
6. A. Chatzipetrou⁶,
7. T. Eiwegger⁷, 
8. D. Firinu⁸, 
9. T. Harr⁹, 
10. E. Knol¹⁰, 
11. A. Matucci¹¹, 
12. O. Palomares¹², 
13. C. Schmidt-Weber¹³, 
14. H.-U. Simon¹⁴, 
15. U. C. Steiner¹⁵, 
16. A. Vultaggio¹¹, 
17. C. A. Akdis^2,3and
18. F. Spertini¹²

Allergy Volume 70, Issue 7, pages 727–754, July 2015

Keywords:

• allergic rhinitis;
• asthma;
• atopic dermatitis;
• eosinophilic disorders;
• food allergy;
• hymenoptera allergy;
• urticaria

Abstract

Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized by living organisms and directed against a specific determinant, for example, a cytokine or receptor. In inflammatory and autoimmune diseases, biologicals have revolutionized the treatment of several immune-mediated disorders.

Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies

Journal of Internal Medicine

Early View (Online Version of Record published before inclusion in an issue)

1. Kian Fan Chung

Article first published online: 15 JUN 2015 DOI: 10.1111/joim.12382

Keywords:

• asthma clusters;
• asthma phenotyping;
• asthma treatments;
• eosinophils;
• neutrophils;
• T helper type 2 (Th2)

Abstract

Asthma is a common heterogeneous disease with a complex pathophysiology that carries a significant mortality rate and high morbidity. Current therapies based on inhaled corticosteroids and long-acting β-agonists remain effective in a large proportion of patients with asthma, but ~10% (considered to have ‘severe asthma’) do not respond to these treatments even at high doses or with the use of oral corticosteroids. Analytical clustering methods have revealed phenotypes that include dependence on high-dose corticosteroid treatment, severe airflow obstruction and recurrent exacerbations associated with an allergic background and late onset of disease.

The Allergies, Immunotherapy, and RhinoconjunctivitiS (AIRS) survey: provider practices and beliefs about allergen immunotherapy

1. Bryan Leatherman MD^1,*, 
2. David P. Skoner MD^2,3, 
3. James A. Hadley MD, FACS⁴,
4. Nicole Walstein PA-C⁵, 
5. Michael S. Blaiss MD⁶, 
6. Mark S. Dykewicz MD⁷, 
7. Timothy Craig DO⁸, 
8. Nancy Smith MS⁹ and
9. Felicia Allen-Ramey PhD¹⁰

10. 1. International Forum of Allergy & Rhinology

       Volume 4, Issue 10, pages 779–788, October 2014

View Full Article (HTML) Enhanced Article (HTML) Get PDF (1227K)

Keywords:

• physician's practice patterns;
• allergens;
• subcutaneous immunotherapy;
• sublingual immunotherapy;
• administration and dosage;
• immunology

Background

The practices and beliefs of the provider specialties that treat allergic rhinoconjunctivitis (ARC) with allergen immunotherapy (AIT) may vary.

Methods

A telephone survey of 500 randomly selected health care practitioners in 7 specialties, conducted in 2012.

Maculopapular eruption and fever due to lamotrigine followed by subsiding flare-ups

This article is part of the supplement: Abstracts from the EAACI Skin Allergy Meeting 2014

Poster presentation

Anna Valerieva^*, Maria Staevska, Vasil Dimitrov and Todor Popov

Clinical and Translational Allergy 2015, 5(Suppl 1):P13  doi:10.1186/2045-7022-5-S1-P13

Introduction

Lamotrigine (LTG), an aromatic antiepileptic drug, is mainly used to manage epilepsy and bipolar / mood disorders. Skin rashes are the most common adverse reaction to this drug that typically develop in the first 8 weeks of treatment.

Case presentation

A 27-year-old Caucasian woman treated with LTG 25 mg PO for a depressive episode was hospitalized in our allergy clinic with highly pruritic maculopapular eruption (MPE), affecting her abdomen, chest, back and forearms, which had started 2 days earlier along with fever of 37.5ºC. A well-defined red dermographism and tenderness of the skin was observed.

Hypersensitivity to Tomato (Lycopersicon esculentum) in Peach-Allergic Patients: rPru p 3 and rPru p 1 Are Predictive of Symptom Severity

Mascheri A1, Farioli L2, Pravettoni V3, Piantanida M3, Stafylaraki C1, Scibilia J1, Mirone C1, Preziosi D1, Nichelatti M4, Pastorello EA5

1Allergology and Immunology Unit, Niguarda Ca’ Granda Hospital, Milan, Italy 2Department of Laboratory Medicine, Niguarda Ca’ Granda Hospital, Milan, Italy 3Clinical Allergy and Immunology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy 4Service of Biostatistics, Niguarda Ca’ Granda Hospital, Milan, Italy 5Allergology and Immunology Unit, Niguarda Ca’ Granda Hospital and Department of Clinical Sciences and Community Health “Università degli Studi di Milano”, Milan, Italy

J Investig Allergol Clin Immunol 2015; Vol. 25(3): 183-189

Abstract Background: The role of allergens in the severity of tomato allergy symptoms has not yet been studied. Objectives: To evaluate the relationship between severe allergic reactions to peach and tomato and between tomato allergy symptoms and the pattern of IgE positivity for rPru p 1, rPru p 3, rPru p 4, rBet v 1, rBet v 2, rBet v 4, rPhl p 1, and rPhl p 12 in order to identify the role of recombinant allergens in the severity of reactions to tomato.

Epidemiology of Anaphylaxis: Contributions From the Last 10 Years

Tejedor-Alonso MA1,2, Moro-Moro M1, Múgica-García MV3

1Allergy Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain 2Medicine and Surgery Department, Universidad Rey Juan Carlos, Alcorcón, Spain 3Allergy Service, Hospital Universitario de la Princesa, Madrid, Spain

J Investig Allergol Clin Immunol 2015; Vol. 25(3): 163-175

Abstract Knowledge of the epidemiology of anaphylaxis has improved during the last 10 years thanks to the increased number of publications with improved methodological robustness. Consequently, we better understand the distribution and frequency of anaphylaxis and the characteristics of fatal anaphylaxis.

Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study

Research article

Ming Zeng, Zhi-Yong Li, Jin Ma, Ping-Ping Cao, Heng Wang, Yong-Hua Cui and Zheng Liu^*

BMC Immunology 2015, 16:37  doi:10.1186/s12865-015-0096-x

Abstract

Background

Phenotype of chronic rhinosinusitis (CRS) may be an important determining factor of the efficacy of anti-inflammatory treatments. Although both glucocorticoids and macrolide antibiotics have been recommended for the treatment of CRS, whether they have different anti-inflammatory functions for distinct phenotypic CRS has not been completely understood. The aim of this study is to compare the anti-inflammatory effects of clarithromycin and dexamethasone on sinonasal mucosal explants from different phenotypic CRS ex vivo.

Allergy immunotherapy prescribing trends for grass pollen-induced allergic rhinitis in Germany: a retrospective cohort analysis

Research

Amanda L. McDonell^1*, Ulrich Wahn², Dirk Demuth¹, Catrina Richards¹, Charlie Hawes³, Jakob Nørgaard Andreasen⁴and Felicia Allen-Ramey⁵

Allergy, Asthma & Clinical Immunology 2015, 11:19  doi:10.1186/s13223-015-0085-x

Abstract (provisional)

Background Allergy immunotherapy is an effective treatment for patients with allergic rhinitis whose symptoms are unresolved with pharmacotherapy. Allergy immunotherapy for grass pollen-induced allergic rhinitis is available in three modalities: subcutaneous immunotherapy and sublingual immunotherapy as a tablet or drop. This study aimed to understand trends in allergy immunotherapy prescribing and practice patterns for grass allergies in adult and paediatric patients in Germany.