Anomalous cutaneous absorption of allergens as cause of skin prick testing adverse reactions in adult patients. Clinical and experimental evidence

A. Antico, M. Arisi, G. Lima

Background. Paediatric age, active eczema and high number of allergens tested in poly-sensitized patients have been pinpointed as possible risk factors of systemic reactions by skin prick testing. As far as atopic eczema concerns, the higher penetration of the allergens into the skin because of the scraping or micro-injuries is an intuitive rationalization. Purpose of the present study is to provide documentary evidence that adverse reactions elicited by anomalous absorption of allergens can occur also in adult patients with apparently normal skin.

Cross-reactivity of a new food ingredient, dun pea, with legumes, and risk of anaphylaxis in legume allergic children

C. Richard, S. Jacquenet, P. Sergeant, D.A. Moneret-Vautrin

Background. Legume allergy is the fifth food allergy in Europe. The dun pea (Pisum sativum sativum var. arvense), a pea belonging to the same subspecies as green pea, has been recently introduced as an ingredient in the human food industry. The aims of this study were to evaluate the cross-reactivity between dun pea and other legumes and to search for modification of allergenicity induced by food technologies. Methods. A series of 36 patients with legume and/or peanut allergy was studied. They underwent skin tests to peanut and a panel of legumes including dun pea.

Seasonal allergic rhinitis affects sinonasal microbiota.

Am J Rhinol Allergy. 2014 Jul-Aug;28(4):281-6. doi: 10.2500/ajra.2014.28.4050.

Choi CH1, Poroyko V, Watanabe S, Jiang D, Lane J, deTineo M, Baroody FM, Naclerio RM, Pinto JM.

Abstract

BACKGROUND:

Microbes and allergens can stimulate the nasal mucosa, potentially leading to the development of acute bacterial rhinosinusitis (ABRS). This study was designed to determine if allergen exposure alters the sinonasal microbiome.

METHODS:

We performed a parallel observational study of healthy adults with seasonal allergic rhinitis (SAR; grass or tree, n = 20) or nonallergic subjects (n = 19).

The expanding family of regulatory B cells

Claudia Mauri and 

Madhvi Menon

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Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK

1. Correspondence to: C. Mauri; E-mail: c.mauri@ucl.ac.uk

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Abstract Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known as regulatory B cells (Bregs), contributes to the maintenance of tolerance, primarily via the production of IL-10.

Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study

Brief Communication

Nadine Jaeckels^1*, Iris Bellinghausen², Petra Fronk¹, Bärbel Heydenreich², Joachim Saloga² and Heinz Decker^1*

Clinical and Translational Allergy 2015, 5:21  doi:10.1186/s13601-015-0065-8

Published: 22 June 2015

Abstract

Background

In a recently performed survey with 4000 randomly selected persons, 68 (7.2 %) of 948 respondents reported intolerance and/or allergy-like symptoms to wine. The aim of this study was to analyze whether a real sensitization to wine proteins could be confirmed by diagnostic and/or immunological settings.

Serum reactome induced by Bordetella pertussis infection and Pertussis vaccines: qualitative differences in serum antibody recognition patterns revealed by peptide microarray analysis

Methodology article

Davide Valentini^12†, Giovanni Ferrara^345†, Reza Advani⁶, Hans O Hallander⁶ and Markus J Maeurer^12*

BMC Immunology 2015, 16:40  doi:10.1186/s12865-015-0090-3

Davide Valentini and Giovanni Ferrara contributed equally to this work.

Published: 1 July 2015

Abstract

Background

Pertussis (whooping cough) remains a public health problem despite extensive vaccination strategies. Better understanding of the host-pathogen interaction and the detailed B. pertussis (Bp) target recognition pattern will help in guided vaccine design. We characterized the specific epitope antigen recognition profiles of serum antibodies (‘the reactome’) induced by whooping cough andB. pertussis (Bp) vaccines from a case–control study conducted in 1996 in infants enrolled in a Bp vaccine trial in Sweden (Gustafsson, NEJM, 1996, 334, 349–355).

Prevalence of perennial severe allergic asthma in Italy and effectiveness of omalizumab in its management: PROXIMA – an observational, 2 phase, patient reported outcomes study

Research

Giorgio Walter Canonica¹, Marta Bartezaghi², Raffaele Marino² and Laura Rigoni^2*

Clinical and Molecular Allergy 2015, 13:10  doi:10.1186/s12948-015-0019-7

Published: 7 July 2015

Abstract

Background

We designed the PROXIMA study (Patient-Reported Outcomes and Xolair ^® In the Management of Asthma) to determine the proportion of patients with severe asthma sensitive to perennial allergens, and to evaluate asthma control and treatment adherence up to 12 months in patients treated with omalizumab in Italian population. In addition, an ancillary study was designed to explore protein biomarkers and characterize them in relation to severe allergic asthma and treatment effects by proteomic approach.

Racial differences in eosinophilic gastrointestinal disorders among Caucasian and Asian

Allergology International

Volume 64, Issue 3, July 2015, Pages 253–259

Open Access

Original article

• Jun Ito^a, b, 
• Takeo Fujiwara^a, b, , , 
• Reiji Kojima^c, 
• Ichiro Nomura^c

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Abstract

Background

Although there is an increasing number of eosinophilic gastrointestinal disorders (EGID) cases including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), being reported globally, no systematic reviews have been conducted to elucidate the racial differences in these disorders. We aimed to show the racial differences, especially among Caucasians and Asians, in the risk of EoE and EGE.

• Acta Otorhinolaryngol Ital
• v.34(1); 2014 Feb
• PMC3970223

Acta Otorhinolaryngol Ital. 2014 Feb; 34(1): 36–41.

PMCID: PMC3970223

Language: English | Italian

Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history

M. GELARDI,1 L. IANNUZZI,1 S. TAFURI,2 G. PASSALACQUA,3 and N. QUARANTA1

SUMMARY

Rhinitis and rhinosinusitis (with/without polyposis), either allergic or non-allergic, represent a major medical problem. Their associated comorbidities and relationship with family history have so far been poorly investigated. We assessed these aspects in a large population of patients suffering from rhinosinusal diseases.

Efficacy and safety of beclomethasone dipropionate nasal aerosol in children with perennial allergic rhinitis

Publication stage: In Press Corrected Proof

William E. Berger, MD, Robert L. Jacobs, MD, Niran J. Amar, MD, Sudeesh K. Tantry, PhD, Jiang Li, MS, Calvin J. Small, MD, MS

Open Access

DOI: http://dx.doi.org/10.1016/j.anai.2015.05.012

Article Info

• Abstract
• Full Text
• Images
• References

Abstract

Background

Beclomethasone dipropionate (BDP) nasal aerosol (non-aqueous) is approved for management of seasonal and perennial allergic rhinitis (PAR) in adolescents and adults.

Objective

To evaluate the efficacy and safety of BDP nasal aerosol at 80 μg/day in children with PAR.

Altered microRNA Expression Profiles of Extracellular Vesicles in Nasal Mucus From Patients With Allergic Rhinitis

	Original Article  Open Access
	Allergy Asthma Immunol Res. 2015 Sep;7(5):449-457. English. Published online Apr 14, 2015.  http://dx.doi.org/10.4168/aair.2015.7.5.449  Copyright © 2015 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease Geping Wu,1 Guanghai Yang,6 Ruxin Zhang,2 Guangyin Xu,3 Ling Zhang,4 Wu Wen,5 Jianbing Lu,1 Jianyong Liu,1 and Yan Yu1 Abstract Purpose Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. Exosomes or extracellular vesicles are nanosized vesicles of endosomal origin released from inflammatory and epithelial cells that have been implicated in allergic diseases. In this study, we characterized the microRNA (miRNA) content of exosomes in AR.

A survey of clinical features of allergic rhinitis in adults

• Med Sci Monit
• v.20; 2014
• PMC4228947

Med Sci Monit. 2014; 20: 2151–2156.

Published online 2014 Nov 4. doi:  10.12659/MSM.891206

PMCID: PMC4228947

Franco Frati,1,A Ilaria Dell’Albani,1,A Giovanni Passalacqua,2,B Sergio Bonini,3,B Oliviero Rossi,4,B Gianenrico Senna,5,B and Cristoforo Incorvaia6,E,F, on behalf of The Adult SURF Study Group

Author information ► Article notes ► Copyright and License information ►

Abstract

Background

Allergic rhinitis (AR) has high prevalence and substantial socio-economic burden.

Material/Methods

The study included 35 Italian Centers recruiting an overall number of 3383 adult patients with rhinitis (48% males, 52% females, mean age 29.1, range 18–45 years).

Approaches to the diagnosis and management of chronic urticaria in children

Korean J Pediatr > 2015 May;58(5) > Article

REVIEW ARTICLE

Korean J Pediatr 2015 May;58(5) :159-164. Published online 2015 May 15.

Sun Hee Choi1, Hey Sung Baek2 Share :    ABSTRACT Most guidelines for chronic urticaria (CU) in infants and children are based on limited pediatric evidence. Current evidence used to guide treatment in children is extrapolated from data focusing on older age groups. CU in children is a different and complex condition than that in adults. Furthermore, there is little published information regarding urticaria in Korean children. The aim of the present article is to review recent research on chronic childhood urticaria and improve the current understanding of its pathogenesis and management.

Asthma trajectories in early childhood: identifying modifiable factors

• PLoS One
• v.9(11); 2014
• PMC4224405

PLoS One. 2014; 9(11): e111922.

Published online 2014 Nov 7. doi:  10.1371/journal.pone.0111922

PMCID: PMC4224405

Lidia Panico,1,* Beth Stuart,2 Mel Bartley,3 and Yvonne Kelly3

Abstract

Background

There are conflicting views as to whether childhood wheezing represents several discreet entities or a single but variable disease. Classification has centered on phenotypes often derived using subjective criteria, small samples, and/or with little data for young children. This is particularly problematic as asthmatic features appear to be entrenched by age 6/7. In this paper we aim to: identify longitudinal trajectories of wheeze and other atopic symptoms in early childhood; characterize the resulting trajectories by the socio-economic background of children; and identify potentially modifiable processes in infancy correlated with these trajectories.