Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care

Research

Sinisa Savic¹, Alexander Marsland², David McKay³, Michael R Ardern-Jones⁴, Tabi Leslie⁵⁶, Olivier Somenzi⁷, Laura Baldock⁸ and Clive Grattan^69*

Allergy, Asthma & Clinical Immunology 2015, 11:21  doi:10.1186/s13223-015-0088-7

Abstract

Background

Omalizumab is approved in the UK as add-on treatment for chronic spontaneous urticaria (CSU) in patients with inadequate response to H ₁ -antihistamines. Ciclosporin is an established but unlicensed 3rd line option for CSU. Two parallel retrospective observational studies were conducted to describe outcomes of treatment and adverse events with omalizumab or ciclosporin for CSU treatment.

Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs in Children and Adolescents: Cross-Intolerance Reactions

Blanca-López N1*, Cornejo-García JA2,3*, Plaza-Serón MC2, Doña I3, Torres-Jaén MJ3, Canto G1, Padilla-España L4, Kidon M5, Perkins JR2, Blanca M3 1Allergy Service, Infanta Leonor Hospital, Madrid, Spain 2Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain 3Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain 4Dermatology Service and Research Unit, Costa del Sol Hospital, Marbella, Spain 5Rheumatology, Immunology and Allergy Service, Department of Paediatric Medicine, Kandang Kerbau Children's Hospital, Singapore *Both authors contributed equally to the manuscript J Investig Allergol Clin Immunol 2015; Vol. 25(4): 259-269    Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are used worldwide and are responsible for several types of drug hypersensitivity reactions (DHRs) in all age groups. The 2 major groups of DHRs to NSAIDs are those induced by immunological mechanisms (selective reactions) and those where inflammatory mediators are released through activation of the prostaglandin-leukotriene pathway without specific immunological recognition (cross-intolerance). In the present review, we focus on cross-intolerance reactions, which are the most frequent DHRs and are becoming a topic of major interest in children and adolescents.

Self-reported adverse reactions and IgE sensitization to common foods in adults with asthma

Research

G. Rentzos^1*, L. Johanson², S. Sjölander⁴, E. Telemo³ and L. Ekerljung²

Clinical and Translational Allergy 2015, 5:25  doi:10.1186/s13601-015-0067-6

Abstract

Background

There is very few data available on the prevalence of food hypersensitivity among adults with asthma. The aim of this study was to explore the prevalence of self-reported adverse reactions and IgE sensitization to the different foods and to determine the spectrum and the prevalence of food-related gastrointestinal symptoms in adults with and with no asthma.

Epidemiology of Anaphylaxis: Contributions From the Last 10 Years

Tejedor-Alonso MA1,2, Moro-Moro M1, Múgica-García MV3

1Allergy Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain 2Medicine and Surgery Department, Universidad Rey Juan Carlos, Alcorcón, Spain 3Allergy Service, Hospital Universitario de la Princesa, Madrid, Spain

J Investig Allergol Clin Immunol 2015; Vol. 25(3): 163-175

Abstract Knowledge of the epidemiology of anaphylaxis has improved during the last 10 years thanks to the increased number of publications with improved methodological robustness. Consequently, we better understand the distribution and frequency of anaphylaxis and the characteristics of fatal anaphylaxis.

Microbiome and Asthma: What Have Experimental Models Already Taught Us?

Journal of Immunology ResearchVolume 2015 (2015), Article ID 614758, 8 pageshttp://dx.doi.org/10.1155/2015/614758Review Article
R. Bonamichi-Santos, M. V. Aun, R. C. Agondi, J. Kalil, and P. Giavina-Bianchi

Abstract

Asthma is a chronic inflammatory disease that imposes a substantial burden on patients, their families, and the community. Although many aspects of the pathogenesis of classical allergic asthma are well known by the scientific community, other points are not yet understood.

Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis

Case Reports in ImmunologyVolume 2015 (2015), Article ID 780824, 3 pageshttp://dx.doi.org/10.1155/2015/780824Case Report
Amit Frenkel,1 Aviel Roy-Shapira,1 Brotfain Evgeni,1 Koyfman Leonid,1Abraham Borer,2 and Moti Klein1

Abstract

We present a case of a 27-year-old man with recurrent episodes of angioedema since he was 19, who responded well to treatment with medical grade cannabis. Initially, he responded to steroids and antihistamines, but several attempts to withdraw treatment resulted in recurrence.

Probiotics for prevention of atopic diseases in infants:systematic review and meta-analysis

1. 1. 
      
2. Gianvincenzo Zuccotti^1,8, 
3. Fabio Meneghin^2,8, 
4. Arianna Aceti^3,8,*, 
5. Giovanni Barone^4,8,
6. Maria Luisa Callegari^5,8, 
7. Antonio Di Mauro^6,8, 
8. Maria Pia Fantini^7,8, 
9. Davide Gori^7,8,
10. Flavia Indrio^6,8,9, 
11. Luca Maggio^4,8,9,
12. Lorenzo Morelli^5,8, 
13. Luigi Corvaglia^3,8,9,10and
14. The Italian Society of Neonatology.

15. 1. Allergy

       Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
    2. Abstract

       Growing evidence underlines the pivotal role of infant gut colonization in the development of the immune system. The possibility to modify gut colonization through probiotic probiotic supplementation during pregnancy and early infancy in preventing atopic diseases.

Effect of anti-gliadin IgY antibody on epithelial intestinal integrity and inflammatory response induced by gliadin

Research article

Naiyana Gujral¹, Ju Won Suh^2* and Hoon H. Sunwoo^1*

BMC Immunology 2015, 16:41  doi:10.1186/s12865-015-0104-1

The electronic version of this article is the complete one and can be found online at:http://www.biomedcentral.com/1471-2172/16/41

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Abstract

Background

Pepsin-trypsin resistant gliadin (PT-gliadin) promotes intestinal tissue inflammation and increases paracellular permeability of immunogenic gliadin peptides into the lamina propria. This leads to the complications seen in the pathogenesis of celiac disease (CD). In this study, specific anti-gliadin IgY antibody was produced and evaluated for its efficacy on gliadin induced intestinal integrity impairment and proinflammatory effects on intestinal epithelial (Caco-2) cell culture model for CD.

Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity

• World J Gastroenterol
• v.21(23); 2015 Jun 21
• PMC4476871

World J Gastroenterol. 2015 Jun 21; 21(23): 7089–7109.

Published online 2015 Jun 21. doi:  10.3748/wjg.v21.i23.7089

PMCID: PMC4476871

Pasquale Mansueto, Alberto D’Alcamo, Aurelio Seidita, and Antonio Carroccio

Author information ► Article notes ► Copyright and License information ►

Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, having a prevalence of 12%-30% in the general population. Most patients with IBS attribute their symptoms to adverse food reactions. We review the role of diet in the pathogenesis of IBS and the importance of dietary factors in the management of these patients.

Bilastine: new insight into antihistamine treatment

Review

Erminia Ridolo^1*, Marcello Montagni¹, Laura Bonzano¹, Cristoforo Incorvaia² and Giorgio Walter Canonica³

Clinical and Molecular Allergy 2015, 13:1  doi:10.1186/s12948-015-0008-x

Published: 15 April 2015

Abstract

Bilastine is a new second generation H1-antihistamine recently approved for the symptomatic treatment of allergic rhinitis (AR) and chronic urticaria (CU). Bilastine epitomizes the evolution of research on antihistamines concerning both efficacy and safety.

Clinical development methodology for infusion-related reactions with monoclonal antibodies

Review
Published online 17 July 2015
OPEN

Citation: Clinical & Translational Immunology (2015) 4, e39; doi:10.1038/cti.2015.14

Lucette Doessegger¹ and Maria Longauer Banholzer¹

¹Safety Risk Management, Licensing and Early Development (LEAD), F. Hoffmann-La Roche AG, Basel, Switzerland

Correspondence: Dr L Doessegger, Safety Risk Management, F. Hoffmann-La Roche, Grenzacherstrasse 124, Basel 4070, Switzerland. E-mail: lucette.doessegger@roche.com

Received 20 March 2015; Revised 2 June 2015; Accepted 2 June 2015

of page

Abstract

Infusion-related reactions (IRRs) are common with monoclonal antibodies (mAbs) and timely related to drug administration and have been reported as anaphylaxis, anaphylactoid reactions and cytokine release syndrome, among other terms used. We address risk management measures for individual patients and for the study and propose a consistent reporting approach in an attempt to allow cross-molecule comparisons. Once the symptoms of IRR have resolved, the mAb may be restarted.

Tree pollen allergens – an update from a molecular perspective

Allergy

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.

1. Claudia Asam, 
2. Heidi Hofer, 
3. Martin Wolf,
4. Lorenz Aglas and
5. Michael Wallner^*

Abstract

It is estimated that pollen allergies affect approximately 40% of allergic individuals. In general, tree pollen allergies are mainly elicited by allergenic trees belonging to the orders Fagales, Lamiales, Proteales and Pinales. Over 25 years ago, the gene encoding the major birch pollen allergen Bet v 1 was the first such gene to be cloned and its product characterized.

Occupational exposure to pesticides and respiratory health

Ali Mamane1,2⇑, 

Isabelle Baldi1,2,3, 

Jean-François Tessier2,

Chantal Raherison1,2,4 and 

Ghislaine Bouvier1,2

Abstract

This article aims to review the available literature regarding the link between occupational exposure to pesticides and respiratory symptoms or diseases. Identification of epidemiological studies was performed using PubMed. 41 articles were included, 36 regarding agricultural workers and five regarding industry workers.

Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study

Allergology International
Vol. 64 (2015) No. 3 p. 272-276

http://doi.org/10.1016/j.alit.2015.04.002

ORIGINAL ARTICLE

Yu Okada¹⁾, Noriyuki Yanagida¹⁾, Sakura Sato²⁾, Motohiro Ebisawa²⁾

1) Department of Pediatrics, Sagamihara National Hospital 2) Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital

Released on J-STAGE 20150715  

Keywords: Milk hypersensitivity; Disease management; Food allergy; Food hypersensitivity; Specific IgE

•  Full Text PDF [444K]

• Abstracts
• References(25)

Background: Low dose reactive cow's milk (CM) allergic children are at high risk of persistent CM allergy and a positive oral food challenge (OFC). The present study aimed to evaluate if the results of a very low dose (VL) OFC with these children contributes to better management of CM allergy. Methods: We retrospectively reviewed subjects with CM allergy who underwent a VL OFC with 3 mL heated CM and had a previous allergic reaction to < 25 mL heated CM in the 2 years before the OFC.