Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial

Research article

Melanie Rae Simpson^1*, Christian Kvikne Dotterud¹², Ola Storrø¹, Roar Johnsen¹ and Torbjørn Øien¹

BMC Dermatology 2015, 15:13  doi:10.1186/s12895-015-0030-1

Abstract

Background

Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.

Malaria eradication and elimination: views on how to translate a vision into reality

Forum

Marcel Tanner^12*, Brian Greenwood³, Christopher J M Whitty³, Evelyn K Ansah⁴, Ric N Price⁵⁶, Arjen M Dondorp⁶⁷,Lorenz von Seidlein⁶⁷, J Kevin Baird⁶⁸, James G Beeson¹⁰⁹, Freya J I Fowkes^1112139, Janet Hemingway¹⁴, Kevin Marsh¹⁵ and Faith Osier¹⁶

BMC Medicine 2015, 13:167  doi:10.1186/s12916-015-0384-6

Abstract

Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria might eventually be eradicated. Their collective views highlight the challenges and opportunities, and explain how multi-factorial and integrated processes could eventually make malaria eradication a reality.

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Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study

PLoS One. 2015 Aug 26;10(8):e0136191. doi: 10.1371/journal.pone.0136191. eCollection 2015.

Burte E1, Bousquet J2, Varraso R1, Gormand F3, Just J4, Matran R5, Pin I6, Siroux V7, Jacquemin B8, Nadif R1.

Abstract

Background

The classification of rhinitis in adults is missing in epidemiological studies.

Objective

To identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach.

Methods

983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms related to rhinitis such as nasal symptoms, hay fever, sinusitis, conjunctivitis, and sensitivities to different triggers (dust, animals, hay/flowers, cold air…) were used.

Immunological events in chronic spontaneous urticaria

Review

Marta Ferrer

Clinical and Translational Allergy 2015, 5:30  doi:10.1186/s13601-015-0074-7

Published: 25 August 2015

Abstract

Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. However, it is only seen among 35–40% of patients.

Does the Maternal Serum IgG Level during Pregnancy in Primary Antibody Deficiency Influence the IgG Level in the Newborn?

Case Reports in Immunology
Volume 2015 (2015), Article ID 286380, 4 pages
http://dx.doi.org/10.1155/2015/286380

Case Report

Vasantha Nagendran,1,2 Noel Emmanuel,3 and Amolak S. Bansal1

1Epsom and St Helier University Hospitals NHS Trust, Carshalton, Surrey SM5 1AA, UK
2St Georges University of London, London SW17 0RE, UK
3St George’s University Hospitals NHS Foundation Trust, Tooting, London SW17 0QT, UK

Received 18 June 2015; Revised 17 August 2015; Accepted 18 August 2015

Abstract

Purpose. To find out if the serum IgG level in the newborn baby was affected by low maternal serum IgG during pregnancy in two newly diagnosed primary antibody deficient patients. 

Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium – an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects

Research article

Annelie F Behndig¹, Karthika Shanmuganathan², Laura Whitmarsh², Nikolai Stenfors¹, Joanna L Brown², Anthony J Frew², Frank J Kelly³, Ian S Mudway³, Thomas Sandström¹ and Susan J Wilson^24*

BMC Pulmonary Medicine 2015, 15:99  doi:10.1186/s12890-015-0096-x

Abstract

Background

Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but controlled human exposure studies have failed to provide a mechanism for this effect. Here we investigated whether diesel exhaust (DE) would induce apoptosis or proliferation in the bronchial epithelium in vivo and thus contribute to respiratory symptoms.

Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist’s View

Annals of Dermatology 2015 ; 27(4): 355~363

Dong-Ho Nahm

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

The current standard medical therapy for atopic dermatitis (AD) mainly focuses on symptomatic relief by controlling skin inflammation with topical corticosteroids and/or topical calcineurin inhibitors. However, the clinical efficacy of pharmacological therapy is often disappointing to both patients and physicians. The terminology of AD contains a historical meaning of eczematous dermatitis caused by hypersensitivity reaction to environmental inhalant or food allergen.

Central obesity and other factors associated with uncontrolled asthma in women

Research

Albertina Varandas Capelo^1*, Vania Matos de Fonseca², Maria Virgínia Marques Peixoto², Sonia Regina de Carvalho¹and Larissa Garcia Guerino¹

Allergy, Asthma & Clinical Immunology 2015, 11:12  doi:10.1186/s13223-015-0076-y

Abstract

Background

Asthma remains an uncontrolled disease. The Comorbidities, particularly obesity, and several other factors have been identified as being individually associated with asthma control, and these factors vary among different countries and between sexes. Studies have suggested that the harmful effects of these factors are greatest among women. The aim of the present study was to identify associated factors with uncontrolled asthma in women at the outpatient clinic of a Federal University Hospital in Rio de Janeiro, Brazil.

Accidental exposures to peanut in a large cohort of Canadian children with peanut allergy

Brief communication

Sabrine Cherkaoui¹, Moshe Ben-Shoshan², Reza Alizadehfar³, Yuka Asai⁴, Edmond Chan⁵, Stephen Cheuk⁶, Greg Shand⁷, Yvan St-Pierre⁸, Laurie Harada⁹, Mary Allen¹⁰ and Ann Clarke^11*

Clinical and Translational Allergy 2015, 5:16  doi:10.1186/s13601-015-0055-x

Abstract

Background

We previously estimated that the annual rate of accidental exposure to peanut in 1411 children with peanut allergy, followed for 2227 patient-years, was 11.9% (95% CI, 10.6, 13.5). This cohort has increased to 1941 children, contributing 4589 patient-years, and we determined the annual incidence of accidental exposure, described the severity, management, location, and identified associated factors.

Examination of Patients Suspected as Having Hypersensitivity to Iodinated Contrast Media with Leukocyte Migration Test

Biological and Pharmaceutical Bulletin
Vol. 37 (2014) No. 11 p. 1750-1757

Language:      English     Japanese   

http://doi.org/10.1248/bpb.b14-00346

Regular Articles

Mikio Saito¹⁾, Manabu Abe¹⁾, Tomoyasu Furukawa²⁾, Motohiro Yagi³⁾, Yoshihiro Koike⁴⁾, Yutaka Wakasugi⁵⁾, Norihiko Tabuchi⁶⁾, Katsuji Uno⁶⁾

1) Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Life Sciences 2) Department of Pharmacy, Niitsu Medical CenterHospital 3) Department of Pharmacy, Brain Disease Center Agano Hospital 4) Department of Pharmacy, Toyoura Hospital 5) Department of Internal Medicine, Suibarago Hospital 6)  Laboratory of Molecular Microbiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Abstracts
• References(42)

In vivo tests may be used for the diagnosis of allergy to iodinated contrast media (ICM); however, the tests do not provide definitive diagnosis and are associated with risks for patients. Diagnoses based on in vitro tests are limited, and there are almost no relevant studies. Herein, the authors examined involvement of allergic reaction from a multilateral standpoint in 39 patients suspected of having ICM allergies using leukocyte migration test (LMT). The positive rate of LMT was 44%.

Racial differences in eosinophilic gastrointestinal disorders among Caucasian and Asian

Jun Ito

,

 Takeo Fujiwara

,

 Reiji Kojima

,

 Ichiro Nomura

Open Access

DOI: http://dx.doi.org/10.1016/j.alit.2015.02.003

 

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Open access funded by Japanese Society of Allergology

Article Info

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Article Outline

1. Introduction
2. Methods
   1. Literature reviews
   2. Analyses
3. Results
4. Discussion
5. Conflict of interest
6. Authors' contributions

Jump to SectionIntroductionMethods  Literature reviews  AnalysesResultsDiscussionConflict of interestAuthors' contributions

Abstract

Background

Although there is an increasing number of eosinophilic gastrointestinal disorders (EGID) cases including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), being reported globally, no systematic reviews have been conducted to elucidate the racial differences in these disorders. We aimed to show the racial differences, especially among Caucasians and Asians, in the risk of EoE and EGE.

Anaphylaxis Preparedness among Preschool Staff before and after an Educational Intervention

Journal of Allergy
Volume 2015 (2015), Article ID 231862, 5 pages
http://dx.doi.org/10.1155/2015/231862

Research Article

Ashley A. Foster,1 Ronna L. Campbell,2 Sangil Lee,3 and Jana L. Anderson2

1Department of Emergency Medicine, University of California, San Francisco, San Francisco, CA, USA
2Department of Emergency Medicine, Mayo Clinic, Rochester, MN, USA
3Department of Emergency Medicine, Mayo Clinic Health System in Mankato, Mankato, MN, USA

Abstract

Introduction. Children with severe food allergies may spend many hours in the preschool setting. Little is known about anaphylaxis recognition and management preparedness among preschool staff. The objective of this study was to assess anaphylaxis preparedness among preschool staff. Methods. Anonymous questionnaires were administered before and after a 40-minute educational seminar on anaphylaxis recognition and management.

Gene expression profiles in chronic idiopathic (spontaneous) urticaria

Abstract:

Background: The pathophysiology of chronic idiopathic (spontaneous) urticaria (CIU) is poorly understood. 

Objective: We hypothesized that a study of gene expression in active lesions from patients with CIU would uncover unexpected associations.