Is a previous diagnosis of asthma a reliable criterion for asthma–COPD overlap syndrome in a patient with COPD?

ORIGINAL RESEARCH

International Journal of Chronic Obstructive Pulmonary Disease » September 2015 Volume 2015:10(1) Pages 1745—1752

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Miriam Barrecheguren,¹ Miguel Román-Rodríguez,² Marc Miravitlles<sup>1

1</sup>Pneumology Department, Hospital Universitari Vall d’Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, ²Primary Health Care Center Son Pisà, IB-Salut, Palma de Mallorca, Spain

Background: Some patients share characteristics of both COPD and asthma. As yet, there is no gold standard to identify patients with the so-called asthma–COPD overlap syndrome (ACOS).
Objective: To describe the differences between ACOS patients and the remaining COPD patients, and to compare the clinical characteristics of patients diagnosed with ACOS by two different criteria: previous diagnosis of asthma before the age of 40 years; and the diagnostic criteria of the Spanish guidelines of COPD.

Sustained improvement of psoriatic lesions in the course of sublingual immunotherapy for airborne allergens: clinical evidence of cross-tolerance

Eur Rev Med Pharmacol Sci. 2015;19(3):392-5.

Theodoropoulos DS1, Morris MS, Morris DL.

Abstract

BACKGROUND:

A patient with psoriasis is presented who was treated with sublingual immunotherapy for airborne allergens for allergic rhinitis. Allergic rhinitis and psoriasis have entirely different cytokine profiles and result from different aberrations of the immune response. Furthermore, T-cell activation in the two diseases uses different presentation systems, psoriasis being a CD8 cytotoxic cell response requiring presentation through the Major Histocompatibility Complex I, while allergic rhinitis and its treatment with sublingual immunotherapy depend on CD4 T-helper cells and presentation by the Major Histocompatibility Complex II.

Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy

September–October, 2015 Volume 3, Issue 5, Pages 743–750.e1

Thomas B. Casale, MD

,

 Jonathan A. Bernstein, MD

,

 Marcus Maurer, MD

,

 Sarbjit S. Saini, MD

,

 Benjamin Trzaskoma, MS

,

 Hubert Chen, MD

,

 Clive E. Grattan, MA, MD, FRCP

,

 Ana Gimenéz-Arnau, MD, PhD

,

 Allen P. Kaplan, MD

,

 Karin Rosén, MD, PhD

Open Access

DOI: http://dx.doi.org/10.1016/j.jaip.2015.04.015Share on mendeleyShare on facebookShare on twitterShare on emailMore Sharing Services

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Background

Data from the 3 omalizumab pivotal trials in patients with chronic idiopathic urticaria/chronic spontaneous urticaria (CIU/CSU) represent the largest database of patients reported to date with refractory disease (omalizumab, n = 733; placebo, n = 242).

Chlorpheniramine-induced anaphylaxis diagnosed by basophil activation test

Asia Pac Allergy. 2015 Jul;5(3):177-180. English.  http://dx.doi.org/10.5415/apallergy.2015.5.3.177

Hyun-Seung Lee,1,2,† Woo-Jung Song,1,2,† Ji-Won Lee,1,2 Young-Yoon Cho,1 Han-Ki Park,1,2 Min-Gyu Kang,1,2 Sang-Heon Cho,1,2 and Seong-Wook Sohn3

1Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.

2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.

3Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang 410-773, Korea.

Abstract

Chlorpheniramine is a widely prescribed H1-antihistamine for relieving urticaria or histamine-mediated allergic reactions. However, although rare, it may cause immediate hypersensitivity reactions. The diagnosis is usually made by provocation test, but its application is often limited due to comorbidities or potential risk of severe reactions.

Revisiting the Dutch hypothesis

September 2015 Volume 136, Issue 3, Pages 521–529

Dirkje S. Postma, MD, PhD, 

Scott T. Weiss, MD, PhD 

,Maarten van den Berge, MD, PhD, Huib A.M. Kerstjens, MD, PhD , Gerard H. Koppelman, MD, PhD

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The Dutch hypothesis was first articulated in 1961, when many novel and advanced scientific techniques were not available, such as genomics techniques for pinpointing genes, gene expression, lipid and protein profiles, and the microbiome. In addition, computed tomographic scans and advanced analysis techniques to dissect (small) airways disease and emphysema were not available.

Environmental exposure to pesticides and respiratory health

1. Ali Mamane1,2⇑, 
2. Chantal Raherison1,2,3, 
3. Jean-François Tessier2,
4. Isabelle Baldi1,2,4 and 
5. Ghislaine Bouvier1,2

+Author Affiliations

1. ¹ISPED – Laboratoire Santé Travail Environnement, Université de Bordeaux, Bordeaux, France
2. ²ISPED – Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France
3. ³Service des Maladies Respiratoire, CHU de Bordeaux, Bordeaux, France
4. ⁴Service de Médecine du Travail, CHU de Bordeaux, Bordeaux, France

1. Ali Mamane, Université de Bordeaux, ISPED, INSERM U897, 146 rue Leo Saignat, Bordeaux, 33076, France. E-mail: ali.mamane@isped.u-bordeaux2.fr

Abstract

Respiratory effects of environmental exposure to pesticides are debated. Here we aimed to review epidemiological studies published up until 2013, using the PubMed database. 20 studies dealing with respiratory health and non-occupational pesticide exposure were identified, 14 carried out on children and six on adults.

Early introduction of food to prevent food allergy. The leap study (learning early about peanut)

Revista Paulista de Pediatria (English Edition)

Available online 28 August 2015

In Press, Uncorrected Proof — Note to users

Open Access

Letter to the Editor

• Nelson Rosário Filho 

Under a Creative Commons license

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doi:10.1016/j.rppede.2015.08.015

Dear Editor, 

Peanut allergy is an increasing global health problem, which affects 1–3% of children in Western countries. The prevalence may have tripled in the last 15 years, which constitutes approximately 100,000 new cases annually in the USA and Canada.^{1, 2 and 3} The most recent evidence, challenging the current guidelines, highlights the benefits of early introduction of peanuts, rather than avoidance, during the infants’ complementary food period. 

Models of Respiratory Infections: Virus-Induced Asthma Exacerbations and Beyond

Saturni S, Contoli M, Spanevello A, Papi A. Allergy Asthma Immunol Res. 2015 Nov;7(6):525-533. English.  Review.  Open Access http://dx.doi.org/10.4168/aair.2015.7.6.525 Abstract

Respiratory infections are one of the main health problems worldwide. They are a challenging field of study due to an intricate relationship between the pathogenicity of microbes and the host's defenses. To better understand mechanisms of respiratory infections, different models have been developed. A model is the reproduction of a disease in a system that mimics human pathophysiology.

Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back

Review

Rik Schrijvers^12*, Liesbeth Gilissen³, Anca Mirela Chiriac⁴⁵ and Pascal Demoly⁴⁵

Clinical and Translational Allergy 2015, 5:31  doi:10.1186/s13601-015-0073-8

Abstract

Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions themselves but also by the use of alternatives which are sometimes less effective or even more dangerous.

Prevention of pruritus with ethyl-chloride in skin prick test: a double-blind placebo-controlled prospective study

Research

Amir Gal-Oz¹², Shmuel Kivity², Yacov Shacham², Elisheva Fiszer², Ori Rogowsky³ and Gil Chernin^1*

Allergy, Asthma & Clinical Immunology 2015, 11:25  doi:10.1186/s13223-015-0091-z

Abstract

Background

Ethyl-chloride (EC) spray was recently shown to be an effective antipruritic agent, when given 15 min after histamine skin-prick test (SPT), without changing the wheal and flare reaction. We aimed to investigate the antipruritic effect of EC on SPT, when given prior to SPT.

Steroid sparing effect of omalizumab in seropositive allergic bronchopulmonary aspergillosis

Beam, Keith T.; Coop, Christopher A. Allergy & Rhinology, Volume 6, Number 2, 2015, pp. e143-e145(3)

Abstract:

Background:

Allergic bronchopulmonary aspergillosis (ABPA) is a common serious hypersensitivity reaction to airway colonization with Aspergillus in patients with asthma or cystic fibrosis. While steroids are effective in controlling the respiratory symptoms of ABPA, they have many side effects that make them undesirable for long term use. Antifungals have been used to reduce dependency on systemic steroids but long term use can be limited by side effects and there is the possibility of developing resistance to azoles. Some clinicians have successfully used anti-immunoglobulin E (anti-IgE) therapy in various populations, though it is frequently added to antifungals.

Autophagy in Airway Diseases: A New Frontier in Human Asthma?

Allergy. 2015 Sep 3. doi: 10.1111/all.12761. [Epub ahead of print]

Zeki AA1, Yeganeh B2, Kenyon NJ1, Post M2, Ghavami S3.

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Abstract

The study of autophagy ('self-eating'), a fundamental cell fate pathway involved in physiological and pathological subcellular processes, opens a newfrontier in the continuous search for novel therapies for human asthma. Asthma is a complex syndrome with different disease phenotypes. Autophagyplays a central role in cell physiology, energy and metabolism, and cell survival.

Effect of high-dose sublingual immunotherapy on respiratory infections in children allergic to house dust mite

Asia Pac Allergy. 2015 Jul;5(3):163-169. English. http://dx.doi.org/10.5415/apallergy.2015.5.3.163

Salvatore Barberi,1 Giorgio Ciprandi,2 Elvira Verduci,1 Enza D'Auria,1 Piercarlo Poli,1 Benedetta Pietra,1Cristoforo Incorvaia,3 Serena Buttafava,4 Franco Frati,4 and Enrica Riva1

1Department of Pediatrics, San Paolo Hospital, 20142 Milan, Italy.

2Department of Medicine, IRCCS-Azienda Ospedaliera Universitaria San Martino, 16132 Genoa, Italy.

3Allergy/Pulmonary Rehabilitation, ICP Hospital, 20100 Milan, Italy.

4Medical and Scientific Department, Stallergenes Italy, 20155 Milan, Italy.

Abstract Background Allergic rhinitis is characterized by eosinophil inflammation. Allergic inflammation may induce susceptibility to respiratory infections (RI). House dust mite (HDM) sensitization is very frequent in childhood. Allergen immunotherapy may cure allergy as it restores a physiologic immune and clinical tolerance to allergen and exerts anti-inflammatory activity.