Twin Studies of Atopic Dermatitis: Interpretations and Applications in the Filaggrin Era

Journal of Allergy
Volume 2015 (2015), Article ID 902359, 7 pageshttp://dx.doi.org/10.1155/2015/902359Review ArticleCamilla Elmose1 and Simon Francis Thomsen1,2

1Department of Dermatology, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark
2Center for Medical Research Methodology, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark

Abstract

Aim. The aim of this study was to conduct a systematic review of population-based twin studies of (a) the concordance and heritability of AD and (b) the relationship between AD and asthma and, furthermore, to reinterpret findings from previous twin studies in the light of the emerging knowledge about filaggrin and its role in the atopic march and provide suggestions for future research in this area.

Rituximab in refractory sarcoidosis: a single centre experience

Case Report

Francesco Cinetto, Nicolò Compagno, Riccardo Scarpa, Giacomo Malipiero and Carlo Agostini^*

Clinical and Molecular Allergy 2015, 13:19  doi:10.1186/s12948-015-0025-9

Abstract

Sarcoidosis is a granulomatous disease whose outcome varies from spontaneous remission to chronic refractory disease. Provided that steroids represent the gold standard as a first line treatment, many immune suppressants drugs are currently used in the disease management. However, refractory disease is still a great challenge. Rituximab is an anti-CD20 chimeric monoclonal antibody, currently used for the treatment of B cell malignancies and systemic autoimmune diseases.

High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?

Journal of Immunology Research
Volume 2015 (2015), Article ID 902863, 8 pages
http://dx.doi.org/10.1155/2015/902863

Research Article

Alena Sekerkova,1 Martin Fuchs,2 Eva Cecrdlova,1 Veronika Svachova,1 Ivana Kralova Lesna,3 Ilja Striz,1 and Helena Tlaskalova-Hogenova4

1Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
2Immunoflow, 199 00 Prague, Czech Republic
3Laboratory for Artherosclerosis Research, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
4Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, ASCR, 142 00 Prague, Czech Republic

Abstract

Background. Food protein-induced proctitis/proctocolitis (FPIP) is the most common noninfectious colitis in children in the first year of life. Along with the overall clinical symptoms, diarrhoea and rectal bleeding are the main manifestations of the disease.

FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy

Journal of Immunology Research
Volume 2015 (2015), Article ID 731381, 7 pages
http://dx.doi.org/10.1155/2015/731381

Research Article

Anna Stelmaszczyk-Emmel,1 Anna Zawadzka-Krajewska,2 Eliza Głodkowska-Mrówka,1 and Urszula Demkow1

1Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Poland
2Department of Pediatric Pneumonology and Allergology, Medical University of Warsaw, Poland

Abstract

Over the last decades allergic diseases has become a major health problem worldwide. The only specific treatment to date is allergen specific immunotherapy (ASIT). Although it was shown that ASIT generates allergen-tolerant T cells, detailed mechanism underlying its activity is still unclear and there is no reliable method to monitor its effectiveness. The aim of our study was to evaluate ASIT influence on the frequency of forkhead box P3 (FoxP3) Tregs in allergic children with various clinical manifestations.

Review on immunotherapy in airway allergen sensitised patients.

Neth J Med. 2015 Jul;73(6):263-9.

van der Valk JP1, de Jong NW, Gerth van Wijk R.

Author information

Abstract

Allergen immunotherapy is a more than 100-year-old treatment in particular for birch pollen, grass pollen, house dust mite and cat dander sensitised allergic patients. The mechanism of allergen-specific immunotherapy is complex. Different hypotheses have been postulated to explain the mode of action, such as a decrease of the number of tissue mast cells, eosinophils and basophils, an increase of IgG4 and IgA synthesis, a shift from Th2 to Th1 cells and an increase in the number and function of IL-10 producing T-regulatory cells (T-reg).

Towards a Clinical Decision Support System for Drug Allergy Management: Are Existing Drug Reference Terminologies Sufficient for Identifying Substitutes and Cross-Reactants?

Authors

William Ogallo, Andrew S. Kanter

Pages

1088 - 1088

DOI

10.3233/978-1-61499-564-7-1088

Series

Studies in Health Technology and Informatics

Ebook

Volume 216: MEDINFO 2015: eHealth-enabled Health

Abstract

Drug allergy cross-reactivity checking is an important component of electronic health record systems. Currently, a single, open-source medication dictionary that can provide this function does not exist. In this study, we assessed the feasibility of using RxNorm and NDF-RT (National Drug File – Reference Terminology) for allergy management decision support.

Allergy Risk Finder: Hypothesis Generation System for Allergy Risks via Web Service

Authors

Eiji Aramaki, Shuko Shikata, Eriko Watabe, Mai Miyabe, Yasuyuki Usuda, Satsuki Ayaya, Shinichiro Kumagaya

Pages

1113 - 1113

DOI

10.3233/978-1-61499-564-7-1113

Series

Studies in Health Technology and Informatics

Ebook

Volume 216: MEDINFO 2015: eHealth-enabled Health

Abstract

This study's aim was to build a web service that automatically collects and tests hypotheses for possible allergy risks.

An eHealth Approach to Reporting Allergic Reactions to Food and Closing the Knowledge Gap

Authors

Christopher Munro, Aida Semic-Jusufagic, Katarzyna Pyrz, Philip Couch, Audrey Dunn-Galvin, Niels Peek, Marina Themis, Clare Mills, Iain Buchan, Jonathan Hourihane, Angela Simpson

Pages

320 - 324

DOI

10.3233/978-1-61499-564-7-320

Series

Studies in Health Technology and Informatics

Ebook

Volume 216: MEDINFO 2015: eHealth-enabled Health

Abstract

There is an important knowledge gap in food allergy management in understanding the factors that determine allergic reactions to food, in gathering objective reports of reactions in real time, and in accessing patients' reaction-histories during consultations.

To Assess the Quality of Life in Patients Suffering from Allergic Rhinitis

Journal of Basic & Applied Sciences- Medical Sciences Pages 501-506 Nikhil Sharma, Prithpal S. Matreja, Monika Gupta, Vipan Gupta,Manish Gupta and Ashwani K. Gupta DOI: http://dx.doi.org/10.6000/1927-5129.2015.11.67

Abstract: Background: Allergic Rhinitis (AR) associated with impairments in patients day-to-day functioning at home and work is a global health problem. It’s associated with sleep disorders, emotional problems, impairment in activities, and social functioning. However, it’s not known to what extent quality of life (QOL) scores, work impairment, or sleep is altered in Indian setup hence, this study was designed to assess the quality of life of patients suffering from allergic rhinitis.

Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps?

Research

Mona-Rita Yacoub^12*, Matteo Trimarchi¹², George Cremona¹², Sara Dal Farra¹², Giuseppe Alvise Ramirez¹², Valentina Canti¹², Emanuel Della Torre¹², Mattia Baldini¹², Patrizia Pignatti³, Mario Bussi¹², Maria Grazia Sabbadini¹², Angelo A Manfredi¹² and Giselda Colombo¹²

Clinical and Molecular Allergy 2015, 13:23  doi:10.1186/s12948-015-0026-8

Abstract

Background

The aetiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is still unknown. The role of atopy and the concept of united airways in such patients are still a matter of debate. In this pilot study we aimed at evaluating the degree of eosinophilic inflammation and the frequency of atopy in a cohort of CRSwNP patients candidate for Functional Endoscopic Sinus Surgery (FESS) and assessing the association between these factors and relapsing forms of CRSwNP.

The adsorption of allergoids and 3-O-desacyl-4′-monophosphoryl lipid A (MPL®) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy

Journal of Inorganic Biochemistry

In Press, Corrected Proof — Note to users

• A.J. Bell, 
• M.D. Heath, 
• S.J. Hewings, 
• M.A. Skinner

Under a Creative Commons license

 Show more

doi:10.1016/j.jinorgbio.2015.08.007

 Open Access

Highlights

•

Vaccine potency is affected by antigen-adjuvant adsorption.

•

MATA-MPL immunotherapy formulations effectively treat IgE mitigated allergy.

•

Allergoids & MPL® are consistently adsorbed in MATA-MPL formulations.

•

Adsorption of MPL® to MCT could be influenced by C–H · · · ·π interactions.

•

MCT could be an alternative adjuvant depot for infectious disease antigens.

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Abstract

Infectious disease vaccine potency is affected by antigen adjuvant adsorption. WHO and EMA guidelines recommend limits and experimental monitoring of adsorption in vaccines and allergy immunotherapies. Adsorbed allergoids and MPL® in MATA-MPL allergy immunotherapy formulations effectively treat IgE mitigated allergy. Understanding vaccine antigen adjuvant adsorption allows optimisation of potency and should be seen as good practice; however current understanding is seldom applied to allergy immunotherapies.

Diagnostic and Therapeutic Management of Chronic Urticaria by Dermatologists and the Role of Dermatology Departments

Actas Dermosifiliogr. 2015;106:528-32 - Vol. 106 Num.7 DOI: 10.1016/j.adengl.2015.06.001

A.M. Giménez-Arnaua,⁎, , J. Vilar Alejob, D. Moreno Ramirezc, en nombre de Grupo de Opinión de Urticaria ◊

a Hospital del Mar, Institut Mar d¿Investigacio Médiques, Barcelona, Spain

b Universitat Autònoma, Barcelona Hospital Universitario Negrin de Gran Canaria, Spain

c Hospital Universitario Virgen Macarena, Sevilla

In June 2014 a group of dermatologists met in Madrid to reflect on our specialty's role in managing a highly prevalent skin disease: chronic urticaria. The reflections were motivated by the advances in the diagnosis and therapeutic management of this condition that have emerged over the last 5 years. Patients with chronic urticaria develop wheals, angioedema, or both almost daily, and their disease flares are accompanied by specifically cutaneous symptoms such as itching.

Consensus Document on Allergic Conjunctivitis (DECA)

J Investig Allergol Clin Immunol 2015; Vol. 25(2): 94-106 Sánchez-Hernández MC1, Montero J2,3*, Rondon C4, Benítez del Castillo JM5*, Velázquez E6,7, Herreras JM8*, Fernández-Parra B9, Merayo-Lloves J10*, Del Cuvillo A11, Vega F12, Valero A13, Panizo C14, Montoro J15, Matheu V16, Lluch-Bernal M17,18, González ML19, González R16, Dordal MT20,21, Dávila I22, Colás C23, Campo P4, Antón E24, Navarro A25 (SEAIC 2010 Rhinoconjunctivitis Committee). * (Spanish Group Ocular Surface-GESOC)

Abstract Allergic conjunctivitis (AC) is an inflammatory disease of the conjunctiva caused mainly by an IgE-mediated mechanism. It is the most common type of ocular allergy. Despite being the most benign form of conjunctivitis, AC has a considerable effect on patient quality of life, reduces work productivity, and increases health care costs.

Eustachian tube dysfunction: consensus statement on definition, types, clinical presentation and diagnosis

Clinical Otolaryngology Volume 40, Issue 5, pages 407–411, October 2015

1. 1. A.G.M. Schilder^1,2, 
   2. M.F. Bhutta^1,2, 
   3. C.C. Butler³, 
   4. C. Holy⁴, 
   5. L.H. Levine^4,5, 
   6. K.J. Kvaerner^6,7, 
   7. G. Norman⁸, 
   8. R.J. Pennings⁹,
   9. D. Poe¹⁰, 
   10. J.T. Silvola¹¹, 
   11. H. Sudhoff¹²and
   12. V.J. Lund^1,2

   Introduction

   A recent systematic review of treatments of Eustachian tube dysfunction commissioned by the UK NIHR Health Technology Assessment (HTA) Programme revealed that an important limitation with the available evidence is a lack of consensus on the definition and diagnosis of this disorder.[1] The HTA report recommended that key to advancing research in this field is achieving consensus on diagnostic criteria for Eustachian tube dysfunction (to identify eligible patients for future trials) and on important clinical outcomes.