Allergen Challenge Chamber: an innovative solution in allergic rhinitis diagnosis

Postep Derm Alergol 2015; XXXII (6): 421–425

DOI (digital object identifier): 10.5114/pdia.2015.56096

 

Edyta Krzych-Fałta, Jerzy Sowa, Oksana Wojas, Barbara Piekarska, Adam Sybilski, Bolesław Samoliński

The Allergen Challenge Chamber (ACC) is definitely a serious challenge on the one hand and an innovative solution in allergic rhinitis diagnosis on the other.

Effects of oral vitamin E on treatment of atopic dermatitis: A randomized controlled trial

J Res Med Sci 2015;20:1053-7

Fariba Jaffary, Gita Faghihi, Arghavan Mokhtarian, Sayed Mohsen Hosseini

ABSTRACT

Background: The pathogenesis of atopic dermatitis (AD) remains to be determined; recently a possible change in the immune system with production of immunoglobulins is proposed. As vitamin E is a potent antioxidant, with the ability to decrease the serum levels of immunoglobulin E (IgE) in atopic patients, we aimed to evaluate the effect of oral vitamin E on treatment of AD.

Asthma and chronic obstructive pulmonary disease overlap syndrome: An update

Journal of Translational Internal Medicine  Volume 3, Issue 4 (Dec 2015)

Ming Lu1 / Wan-zhen Yao1

1Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China

© 2015 Ming Lu et al., published by De Gruyter Open. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Evolution of the immune system in humans from infancy to old age

A. Katharina Simon, Georg A. Hollander, Andrew McMichael

Published 23 December 2015.DOI: 10.1098/rspb.2014.3085

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Abstract

This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.

Current and future biomarkers in allergic asthma

1. 1. 
      
2. 

   Allergy
3. Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)                                                                                      Ulrich M. Zissler¹, 
4. Julia Esser-von Bieren¹,
5. Constanze A. Jakwerth¹, 
6. Adam M. Chaker^1,2 and
7. Carsten B. Schmidt-Weber^1,*

DOI: 10.1111/all.12828

Abstract

Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers for allergic rhinitis and allergic asthma. The number of genes related to allergic rhinitis and allergic asthma increases steadily, however prognostic genes have not yet entered clinical application. We hypothesize that the combination of multiple genes may generate biomarkers with prognostic potential.

Refractory Immunological Thrombocytopenia Purpura and Splenectomy in Pregnancy

Case Reports in Immunology Volume 2015 (2015), Article ID 216362, 4 pages
http://dx.doi.org/10.1155/2015/216362

Case Report

Santiago Bernal-Macías,1 Laura-Marcela Fino-Velásquez,1 Felipe E. Vargas-Barato,2,3 Lucio Guerra-Galue,4 Benjamín Reyes-Beltrán,1 and Adriana Rojas-Villarraga1

1Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia
2Surgery Department, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia
3Surgery Department, Hospital Universitario Mayor-Mederi (HUM), Bogotá, Colombia
4Gynaecology Department, Hospital Universitario Mayor-Mederi (HUM), Bogotá, Colombia

Abstract

Thrombocytopenia is defined as a platelet count of less than 100,000 platelets per microlitre (mcL). Thrombocytopenia develops in approximately 6-7% of women during pregnancy and at least 3% of these cases are caused by immunological platelet destruction. Herein, we present a pregnant woman who develops at the first trimester autoimmune thrombocytopenia purpura associated with positive antiphospholipid antibodies.

Cow's Milk Allergy: the Relevance of IgE

Allergy Asthma Immunol Res. 2016 Jan; 8(1): 86–87.

Maria Angela Tosca,1 Angela Pistorio,2 Giovanni Arturo Rossi,1 and Giorgio Ciprandi3

Author information ► Article notes ► Copyright and License information ►

Cow's milk allergy (CMA) accounts for most diagnosed food allergies, mainly in the first year of life.1CMA can cause severe anaphylaxis.2 CMA management is based on strict avoidance and the prescription of rescue medication.

Cow's milk (CM) contains more than 40 proteins, including casein (Bos d 8), -lactalbumin (Bos d 4), and -lactoglobulin (Bos d 5), identified as major milk allergens.1 Serum specific IgE (sIgE) to casein characterized patients with persistent CMA,3 CM tolerance,4 and reactivity to baked milk.5

Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose

Review

Pascal Demoly^1*, Gianni Passalacqua², Moises A. Calderon³ and Tarik Yalaoui⁴

Clinical and Translational Allergy 2015, 5:44  doi:10.1186/s13601-015-0088-1

Abstract

Sublingual immunotherapy (SLIT) is an effective and well-tolerated method of treating allergic respiratory diseases associated with seasonal and perennial allergens. In contrast to the subcutaneous route, SLIT requires a much greater amount of antigen to achieve a clinical effect. Many studies have shown that SLIT involves a dose–response relationship, and therefore it is important to use a proven clinically effective dose from the onset of treatment, because low doses are ineffective and very high doses may increase the risk of side effects.

Ethnic sensitivity assessment of fluticasone furoate/vilanterol in East Asian asthma patients from randomized double-blind multicentre Phase IIb/III trials

• Annette S. Gross, 
• Caroline Goldfrad, 
• Soichiro Hozawa, 
• Mark H. James, 
• Christine S. Clifton, Y
• utaro Sugiyama and 
• Loretta Jacques

BMC Pulmonary Medicine201515:165

DOI: 10.1186/s12890-015-0159-z

Abstract

Background

Fluticasone furoate (FF)/vilanterol (VI) is a once daily (OD) inhaled corticosteroid/long-acting β2-agonist combination asthma therapy approved in Japan and the EU. FF/VI efficacy and safety data from asthma studies including patients in East Asia were evaluated to assess ethnic sensitivity.

Epitope specificity determines cross-protection of a SIT-induced IgG4 antibody

Allergy
Volume 71, Issue 1, pages 36–46, January 2016

E. Gadermaier¹, 

L. K. James², 

M. H. Shamji³, 

K. Blatt⁴, 

K. Fauland⁵, 

P. Zieglmayer⁶, 

T. Garmatiuk¹, 

M. Focke-Tejkl¹, 

M. Villalba⁷, 

R. Beavil², 

W. Keller⁵,

P. Valent⁴, 

S. R. Durham³, 

H. J. Gould²,

S. Flicker¹ and

R. Valenta^1,* 

Abstract

Background

The calcium-binding 2EF-hand protein Phl p 7 from timothy grass pollen is a highly cross-reactive pollen pan-allergen that can induce severe clinical symptoms in allergic patients. Recently, a human monoclonal Phl p 7-specific IgG₄ antibody (mAb102.1F10) was isolated from a patient who had received grass pollen-specific immunotherapy (SIT).

The Eosinophil in Infection

Clinical Reviews in Allergy & Immunology pp 1-14

First online: 21 December 2015

• Karen A. Ravin
• , Michael Loy

Abstract

First described by Paul Ehrlich in 1879, who noted its characteristic staining by acidophilic dyes, for many years, the eosinophil was considered to be an end-effector cell associated with helminth infections and a cause of tissue damage. Over the past 30 years, research has helped to elucidate the complexity of the eosinophil’s function and establish its role in host defense and immunity. Eosinophils express an array of ligand receptors which play a role in cell growth, adhesion, chemotaxis, degranulation, and cell-to-cell interactions. They play a role in activation of complement via both classical and alternative pathways.

Asthma under/misdiagnosis in primary care setting: an observational community-based study in Italy

Maria Sandra Magnoni, Marco Caminati, Gianenrico Senna, Fabio Arpinelli, Andrea Rizzi, Anna Rita Dama, Michele Schiappoli,Germano Bettoncelli and Gaetano Caramori

Clinical and Molecular Allergy201513:26

Abstract

Background

Published data suggest that asthma is significantly under/misdiagnosed. The present community-based study performed in Italy aims at investigating the level of asthma under/misdiagnosis among patients referring to the General Practitioner (GP) for respiratory symptoms and undergoing Inhaled corticosteroids.