Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions

Current Allergy and Asthma Reports March 2016, 16:23

Open Access

Louisa K. James

, Stephen J. Till                                      

 

Abstract:

IgG4 is the least abundant IgG subclass in human serum, representing less than 5 % of all IgG. Increases in IgG4 occur following chronic exposure to antigen and are generally associated with states of immune tolerance. In line with this, IgG4 is regarded as an anti-inflammatory antibody with a limited ability to elicit effective immune responses. Furthermore, IgG4 attenuates allergic responses by inhibiting the activity of IgE.

Diagnosis and Management of Recurrent Respiratory Tract Infections in Children: A Practical Guide

Urs Beat Schaad ^1, * ; Susanna Esposito ² ; and Cem Hasan Razi ³

Archives of Pediatric Infectious Diseases. 4(1): e31039 , DOI: 10.5812/pedinfect.31039

Abstract

Context: Respiratory tract infections (RTIs) affect children all over the world and are associated with significant morbidity and mortality. RTIs are usually triggered by viruses, though bacterial infections are also common.

Results: Children are particularly susceptible to RTIs due to the relative immaturity of their immune systems, and genetic factors (such as family history of atopy) and/or environmental factors (such as exposure to pollution and pathogens) also render certain populations more vulnerable to infection.

Current status of allergy prevalence in Germany

Position Paper

Allergo Journal International February 2016, Volume 25, Issue 1, pp 6-10

Position paper of the Environmental Medicine Commission of the Robert Koch Institute

• Karl-Christian Bergmann
• , Joachim Heinrich
• , Hildegard Niemann 

Abstract

The lifetime prevalence of allergic diseases in adults in Germany [self-reported doctor diagnosed allergic diseases, Study on Adult Health in Germany (Studie zur Gesundheit Erwachsener in Deutschland, DEGS1, 2008–2011) of the Robert Koch Institute] is 8.6 % for asthma, 14.8 % for hay fever, 3.5 % for atopic dermatitis, 8.1 % for contact dermatitis, 4.7 % for food allergies, and 2.8 % for insect venom allergies. Almost 20 % of German adults are currently affected by at least one allergy.

Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy

SHORT REPORT

OPEN ACCESS

Paloma Poza-Guedes, 

Yvelise Barrios, 

Ruperto González-Pérez, 

Inmaculada Sánchez-Machín, 

Andres Franco and 

Víctor Matheu

• Email author

Allergy, Asthma & Clinical Immunology201612:7

DOI: 10.1186/s13223-016-0111-7

Abstract

Rationale

The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of many entities.

Methods and Results

A 1 year retrospective study of pediatric patients complaining exclusively gastrointestinal symptoms after cow’s milk consumption and at least one positive specific IgE (sIgE) to cow’s milk (CM) proteins (CMP) was done (n = 39).

Clostridium butyricum in combination with specific immunotherapy converts antigen-specific B cells to regulatory B cells in asthmatic patients

Article | OPEN

• Hong-Ying Liao
• , Li Tao
• , Jian Zhao
• , Jie Qin
• , Gu-Cheng Zeng
• , Song-Wang Cai
• , Yun Li
• , Jian Zhang
•  &Hui-Guo Chen. 
Scientific Reports 6, Article number: 20481 (2016) doi:10.1038/srep20481.
Abstract
The effect of antigen specific immunotherapy (SIT) on asthma is supposed to be improved. Published data indicate that administration of probiotics alleviates allergic diseases. B cells play important roles in the pathogenesis of allergic diseases. This study aims to modulate antigen specific B cell property by the administration of Clostridium butyrate (CB) in combination with SIT.

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis Executive Summary

International Forum of Allergy & Rhinology

Special Issue: International Consensus in Allergy and Rhinology 2016 Report: Rhinosinusitis

Volume 6, Issue S1, pages S3–S21, February 2016

1. Richard R. Orlandi MD^1,*, 
2. Todd T. Kingdom MD² and
3. Peter H. Hwang MD³

SEARCH

Search Scope

• Abstract
• Article
• References
• Cited By

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Keywords:

• rhinosinusitis;
• chronic rhinosinusitis;
• acute rhinosinusitis;
• recurrent acute rhinosinusitis;
• evidence-based medicine;
• systematic review;
• endoscopic sinus surgery

Background

The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). This executive summary consolidates the findings of the ICAR:RS document.

Quality of life in patients with food allergy

• Darío Antolín-AmérigoEmail author, 
• Luis Manso, 
• Marco Caminati, 
• Belén de la Hoz Caballer, 
• Inmaculada Cerecedo, 
• Alfonso Muriel, 
• Mercedes Rodríguez-Rodríguez, 
• José Barbarroja-Escudero, 
• María José Sánchez-González, 
• Beatriz Huertas-Barbudo and 
• Melchor Alvarez-Mon

Clinical and Molecular Allergy201614:4

DOI: 10.1186/s12948-016-0041-4

Abstract

Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in this kind of patients by performing a complete review of the literature and also describing the factors that may influence, to a greater extent, the quality of life of patients with food allergy and analyzing the different questionnaires available.

The Rhinitis Control Scoring System: Development and Validation

 American Journal of Rhinology & Allergy, Volume 30, Number 1 

Authors: Boulay, Marie-Eve; Boulet, Louis-Philippe

Source: American Journal of Rhinology & Allergy, Volume 30, Number 1, January/February 2016, pp. 54-59(6)

 

Abstract:

Background: 

Allergic rhinitis is a common health problem that requires regular monitoring of symptoms to provide adequate treatment. There is a need to develop rhinitis control assessment tools that are meaningful and easy to interpret by both the patient and the practitioner. 

Ethnic variations in asthma hospital admission, readmission and death: a retrospective, national cohort study of 4.62 million people in Scotland

RESEARCH ARTICLE

OPEN ACCESS

• Aziz SheikhEmail author, 
• Markus F. C. Steiner, 
• Genevieve Cezard, 
• Narinder Bansal, 
• Colin Fischbacher, 
• Colin R. Simpson, 
• Anne Douglas, 
• Raj Bhopal and
• on behalf of the SHELS researchers

BMC Medicine201614:3

DOI: 10.1186/s12916-015-0546-6

©  Sheikh et al. 2016

Abstract

Background

Our previous meta-analysis found that South Asians and Blacks in the UK were at a substantially increased risk of hospital admission from asthma. These estimates were, however, derived from pooling data from a limited number of now dated studies, confined to only three very broad ethnic groups (i.e. Whites, South Asians and Blacks) and failed to take account of possible sex-related differences in outcomes within these ethnic groups. We undertook the first study investigating ethnic variations in asthma outcomes across an entire population.

Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations

Volume: - Issue:
Firstpage: 0 - Lastpage: 0
D. Lal - A.A. Jategaonkar - L. Borish - L.R. Chambliss - S.H. Gnagi - P.H. Hwang - M.A. Rank - J.A. Stankiewicz - V.J. Lund

BACKGROUND: Management of rhinosinusitis during pregnancy requires special considerations.
OBJECTIVES: 1. Conduct a systematic literature review for acute and chronic rhinosinusitis (CRS) management during pregnancy. 2. Make evidence-based recommendations.
METHODS: The systematic review was conducted using MEDLINE and EMBASE databases and relevant search terms. Title, abstract and full manuscript review were conducted by two authors independently. A multispecialty panel with expertise in management of Rhinological disorders, Allergy-Immunology, and Obstetrics-Gynecology was invited to review the systematic review. Recommendations were sought on use of following for CRS management during pregnancy: oral corticosteroids; antibiotics; leukotrienes; topical corticosteroid spray/irrigations/drops; aspirin desensitization; elective surgery for CRS with polyps prior to planned pregnancy; vaginal birth versus planned Caesarian for skull base erosions/ prior CSF rhinorrhea.

EQ-5D Utilities in Chronic Spontaneous/Idiopathic Urticaria

Original Research Article

PharmacoEconomics

pp 1-7

First online: 20 January 2016

Open Access

• Emma Hawe
• , Doreen McBride
• , Maria-Magdalena Balp
• , Haijun Tian
• , Anna Halliday
• , Donald E. Stull 

---

 View Article

Abstract

Objectives

To obtain utility estimates suitable for use in economic models for chronic spontaneous (idiopathic) urticaria (CSU).

Methods

Patient-level data from three randomized clinical trials—ASTERIA I, ASTERIA II and GLACIAL—were analysed. Health states were derived from the Urticaria Activity Score over 7 days (UAS7); higher scores denote greater activity. The health state score ranges were urticaria free: 0; well-controlled urticaria: 1–6; mild urticaria: 7–15; moderate urticaria: 16–27; and severe urticaria: 28–42. The mean EQ-5D utilities were calculated for each health state.