Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation

• Scientific Reports 6, Article number: 28616 (2016)
• doi:10.1038/srep28616

Article | OPEN

Saskia Trump

, Matthias Bieg

, Zuguang Gu

, Loreen Thürmann

, Tobias Bauer

, Mario Bauer

, Naveed Ishaque

, Stefan Röder

, Lei Gu

, Gunda Herberth

, Christian Lawerenz

, Michael Borte

, Matthias Schlesner

, Christoph Plass

, Nicolle Diessl

, Markus Eszlinger

, Oliver Mücke

, Horst-Dietrich Elvers

, Dirk K. Wissenbach

, Martin von Bergen

, Carl Herrmann

, Dieter Weichenhan

, Rosalind J. Wright

, Irina Lehmann

 & Roland Eils

Abstract: Psychological stress during pregnancy increases the risk of childhood wheeze and asthma. However, the transmitting mechanisms remain largely unknown. Since epigenetic alterations have emerged as a link between perturbations in the prenatal environment and an increased disease risk we used whole genome bisulfite sequencing (WGBS) to analyze changes in DNA methylation in mothers and their children related to prenatal psychosocial stress and assessed its role in the development of wheeze in the child. We evaluated genomic regions altered in their methylation level due to maternal stress based of WGBS data of 10 mother-child-pairs.

UK prescribing practices as proxy markers of unmet need in allergic rhinitis: a retrospective observational study

Article | OPEN

npj Primary Care Respiratory Medicine 26, Article number: 16033 (2016) doi:10.1038/npjpcrm.2016.33

David B Price

, Glenis Scadding

, Claus Bachert

, Hesham Saleh

, Shuaib Nasser

, Victoria Carter

, Julie von Ziegenweidt

, Alice M S Durieux

 & Dermot Ryan

Abstract

Little data on UK prescribing patterns and treatment effectiveness for allergic rhinitis (AR) are available. We quantified unmet pharmacologic needs in AR by assessing AR treatment effectiveness based on the prescribing behaviour of UK general practitioners (GP) during two consecutive pollen seasons (2009 and 2010). We conducted a retrospective observational study with the data from the Optimum Patient Care Research Database.

Hypersensitivities to Sesame and other common edible seeds

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) DOI: 10.1111/all.12962

Adesh Patel andSami L. Bahna*

Abstract

Several seeds have been increasingly incorporated in various food items, with consequent risk of hypersensitivity reactions that are often severe. Identification of the specific seed as the culprit is often not explored or is difficult to verify. In this article, we reviewed the English literature from January 1930 to March 2016 using PubMed and Google Scholar searching for publications relevant to hypersensitivity to common edible seeds, namely sesame, sunflower seed, poppy seed, pumpkin seed, flaxseed, and mustard seed.

Crisaborole and its potential role in treating atopic dermatitis: overview of early clinical studies

Immunotherapy Posted online on June 10, 2016. (doi:10.2217/imt-2016-0023) Drug Evaluation    LT Zane*,1, S Chanda1, K Jarnagin1, DB Nelson1, L Spelman2 & LF Stein Gold3 Atopic dermatitis (AD), a chronic, relapsing, inflammatory skin disease that is characterized by intense pruritus and eczematous lesions with up to 90% of patients presenting with mild to moderate disease. Current topical treatments for AD have not changed in over 15 years and are associated with safety concerns. In AD, overactivity of phosphodiesterase 4 (PDE4), leads to inflammation and disease exacerbation.

Markers of tolerance development to food allergens

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

1. Marta Ponce¹, 
2. Susanne C. Diesner¹, 
3. Zsolt Szépfalusi¹ and
4. Thomas Eiwegger^1,2,*

• Abstract
• Cited By

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Abstract

IgE-mediated reactions to food allergens are the most common cause of anaphylaxis in childhood. Although allergies to cows milk, egg or soy proteins, in contrast to peanut and tree nut allergens, resolve within the first 6 years of life in up to 60% due to natural tolerance development, this process is not well understood.

How does the efficacy and safety of Oralair® compare to other products on the market?

REVIEW

VIDEO

Video abstract presented by Désirée Larenas-Linnemann. Abstract: Due to differences between allergen immunotherapy (AIT) trials in patient populations, trial design (including primary efficacy variables), the definition of a pollen season, data analysis

Therapeutics and Clinical Risk Management » Volume 12

Désirée Larenas-Linnemann

Pediatric Allergy and Asthma Clinic, Department of Investigation, Hospital Médica Sur, México City, México

Abstract: Due to differences between allergen immunotherapy (AIT) trials in patient populations, trial design (including primary efficacy variables), the definition of a pollen season, data analysis, and comparisons between AIT products with existing data, is not possible nor valid. The efficacy of two grass pollen AIT tablets, Oralair^® and Grazax^®/Grastek^®, should not be compared by looking at the percentage of score improvement in their respective trials.

Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

Wandalsen GF, Mendes AI, Matsumoto F, Solé D

Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

J Investig Allergol Clin Immunol 2016; Vol 26(3): 156-160doi: 10.18176/jiaci.0036

Abstract

Objectives: To standardize acoustic rhinometry (AR) in nasal provocation tests (NPTs) with histamine in children and adolescents.

Patients and Methods: We performed a cross-sectional validation to compare AR with anterior active rhinomanometry (AAR) during histamine NPT in 20 children and adolescents with persistent allergic rhinitis and 20 controls. Changes in total nasal resistance (AAR) were compared with changes in nasal volume in the first 5 cm (V5). 

Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis

Authors: E. Cantone; M. Iengo

Source: American Journal of Rhinology & Allergy  2016 June 2

Publisher: OceanSide Publications, Inc

Abstract:

Background: Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis.

Cross sectional questionnaire-based internet study: Self-perception and clinical course of drug allergy in Greece

Article in Press

Michael P. Makris

,

 Theodoros N. Sergentanis

,

 Xenophon Aggelides

,

 Stamatios Tzanninis

,

 Efthimia Polyzou

,

 Dimitrios Rigopoulos

,

 Theodora Psaltopoulou

Open Access

• 
  Abstract
• Full Text
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• References
• Supplemental Materials

Abstract

Background

Data on self perception of drug allergy in the general population are lacking. Epidemiological studies focus either on specific populations or document adverse drug reactions in general. Our objective was to document self-reported drug allergy in Greece, through a simple, informative internet-based questionnaire.

IgE in the diagnosis and treatment of allergic disease

Thomas A.E. Platts-Mills, MD, PhD

,

 Alexander J. Schuyler, BS, BA

,

 Elizabeth A. Erwin, MD

,

 Scott P. Commins, MD, PhD

,

 Judith A. Woodfolk, MBChB, PhD

DOI: http://dx.doi.org/10.1016/j.jaci.2016.04.010Article Info

• Abstract
• Full Text
• Images
• References

Article Outline

1. Chronic asthma in patients with sensitization to 1 or more perennial allergens
2. Diagnostic relevance of IgE antibodies to asthma
3. Understanding the role of allergens in asthmatic patients and the relevance of IgE antibodies
4. Sensitization to fungi colonizing the skin, nails, or lungs as a risk factor for allergic disease
5. Role of IgE assays in the diagnosis of different forms of food allergy: peanut anaphylaxis, eosinophilic esophagitis (EoE), and delayed anaphylaxis to red meat (the alpha-gal syndrome)
6. Relevance of the route of sensitization to the specificity and titer of IgE antibody responses
7. Conclusions
8. References

Traditionally, the concept of allergy implied an abnormal response to an otherwise benign agent (eg, pollen or food), with an easily identifiable relationship between exposure and disease. However, there are syndromes in which the relationship between exposure to the relevant allergen and the “allergic” disease is not clear.

Weekly injection of histaglobulin produces long-term remission in chronic urticaria: A prospective clinical study

Indian J Pharmacol. 2016 May-Jun; 48(3): 292–297.

doi:  10.4103/0253-7613.182884

PMCID: PMC4900003

Gurumoorthy Rajesh, Subramaniam Keerthi, Kaliaperumal Karthikeyan, and Murugan Venkatesan1

Author information ► Article notes ► Copyright and License information ►

Abstract

Objective:

Treatment of chronic urticaria (CU) can be difficult in many patients. Achieving long-term remission and reducing the requirement of antihistamines are vital in CU. The objective of this study was to assess the effectiveness of injection histaglobulin, a complex of histamine and human immunoglobulin, in producing relief in patients with CU.

Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal

J Investig Allergol Clin Immunol 2016; Vol 26(3): 177-184 doi: 10.18176/jiaci.0039

Sánchez J, Zakzuk J, Cardona R

Abstract

Background: Antihistamines are the first line of treatment for chronic spontaneous urticaria. However, there is no effective method to predict whether an antihistamine will have a beneficial clinical effect or not.

Objective: To assess whether the change in histamine-induced wheal and flare measurements 24 hours after administration of antihistamine can predict the efficacy of treatment.

Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

J Investig Allergol Clin Immunol 2016; Vol 26(3): 144-155 doi: 10.18176/jiaci.0058

Rosado Ingelmo A1, Doña Diaz I2, Cabañas Moreno R3, Moya Quesada MC4, García-Avilés C5, García Nuñez I6, Martínez Tadeo JI7, Mielgo Ballesteros R8, Ortega-Rodríguez N9, Padial Vilchez MA10, Sánchez-Morillas L11, Vila Albelda C1, Moreno Rodilla E12*, Torres Jaén MJ2*

Abstract

The objective of these guidelines is to ensure efficient and effective clinical practice. The panel of experts who produced this consensus document developed a research protocol based on a review of the literature.
The prevalence of allergic reactions to iodinated contrast media (ICM) is estimated to be 1:170 000, that is, 0.05%-0.1% of patients undergoing radiologic studies with ICM (more than 75 million examinations per year worldwide).

What is new and upcoming in the world of chronic urticaria?

Special Issue: Chronic Urticaria. Challenges, Insights and New Directions. Proceedings of the second Global Urticaria Forum, November 2015, Berlin

Volume 30, Issue Supplement S5, pages 5–6, July 2016

1. M. Maurer¹, 
2. A.M. Giménez-Arnau^2,* and
3. T. Zuberbier¹

• Article
• References
• Cited By

This supplement presents a summary of the key topics discussed during plenary sessions, workshops and debates at the second international Global Urticaria Forum, which was held in Berlin, Germany in November 2015. This interactive meeting was an excellent opportunity to present new data (both from clinical studies and real-life experience) to the medical urticaria community and to gauge opinion on remaining unmet need and unanswered questions.

Analysis of the quality of life of patients with asthma and allergic rhinitis after immunotherapy

• Postepy Dermatol Alergol
• v.33(2); 2016 Apr
• PMC4884771

Postepy Dermatol Alergol. 2016 Apr; 33(2): 134–141.

Published online 2016 May 16. doi:  10.5114/pdia.2015.48061

PMCID: PMC4884771

Małgorzata Filanowicz,1 Ewa Szynkiewicz,1 Bernadeta Cegła,1 and Zbigniew Bartuzi2

Author information ► Article notes ► Copyright and License information ►

Abstract

Aim

To assess the quality of life of Polish patients with asthma and/or allergic rhinitis before the implementation and after 30–36 months of immunotherapy.

Material and methods

Two hundred patients have been involved in the study: 101 with allergic asthma and 99 with pollinosis. In order to collect research material, the Polish versions of AQLQ (Asthma Quality of Life) and RQLQ (Rhinoconjunctivitis Quality of Life) questionnaires have been used.