Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

1. G. Hoarau^a, 
2. P. K. Mukherjee^b, 
3. C. Gower-Rousseau^c, 
4. C. Hager^b, 
5. J. Chandra^b,
6. M. A. Retuerto^b, 
7. C. Neut^a, 
8. S. Vermeire^d, 
9. J. Clemente^e,^f, 
10. J. F. Colombel^c,^g, 
11. H. Fujioka^h,
12. D. Poulain^a, 
13. B. Sendid^a, 
14. M. A. Ghannoum^b

+Author Affiliations

1. aInserm U995-Team 2, Université Lille 2, Faculté de Médecine H. Warembourg, Pôle Recherche, CHRU de Lille, Lille, France
2. bCenter for Medical Mycology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
3. cEpimad Registry, Epidemiology Unit and LIRIC Inserm 995, Lille University and Hospital, Lille, France
4. dDepartment of Gastroenterology, University Hospital Leuven, Leuven, Belgium
5. eDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
6. fImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
7. gDepartment of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
8. hEM Core Facility, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

1. Address correspondence to B. Sendid, bsendid@univ-lille2.fr, or M. A. Ghannoum,Mahmoud.Ghannoum@case.edu.

1. G.H. and P.K.M. contributed equally to the study.
2. Editor Robert A. Bonomo, Louis Stokes Veterans Affairs Medical Center

 

Next Section

ABSTRACT

Crohn’s disease (CD) results from a complex interplay between host genetic factors and endogenous microbial communities. In the current study, we used Ion Torrent sequencing to characterize the gut bacterial microbiota (bacteriome) and fungal community (mycobiome) in patients with CD and their nondiseased first-degree relatives (NCDR) in 9 familial clusters living in northern France-Belgium and in healthy individuals from 4 families living in the same area (non-CD unrelated [NCDU]).

Clinical Relevance of IgE to Profilin and/or Polcalcin in Pollen-Sensitized Patients

Editor's Choice -- Free Access

Int Arch Allergy Immunol 2016;169:101-107 

(DOI:10.1159/000444279)

San Nicoló M. · Braun T. · Eder K. · Berghaus A. · Gröger M. 

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University Munich, Munich, Germany

Abstract

Background: Component-resolved diagnostics is gaining importance in allergy diagnostics. Allergen extracts contain components with different rates of prevalence and clinical relevance, which can be subdivided at molecular level into major and minor allergens.

Setting Occupational Exposure Limits for Chemical Allergens—Understanding the Challenges

• Journal List
• Taylor & Francis Open Select
• PMC4685595

Journal of Occupational and Environmental Hygiene

Taylor & Francis

J Occup Environ Hyg. 2015 Nov 25; 12(sup1): S82–S98.

Published online 2015 Nov 19. doi:  10.1080/15459624.2015.1072277

PMCID: PMC4685595

NIHMSID: NIHMS746362

G. S. Dotson, a , * A. Maier, a , b P. D. Siegel, c S. E. Anderson, c B. J. Green, c A. B. Stefaniak, d C. D. Codispoti, e and I. Kimber f

Author information ► Copyright and License information ►

Abstract

Chemical allergens represent a significant health burden in the workplace. Exposures to such chemicals can cause the onset of a diverse group of adverse health effects triggered by immune-mediated responses. Common responses associated with workplace exposures to low molecular weight (LMW) chemical allergens range from allergic contact dermatitis to life-threatening cases of asthma.

Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®

Chandler, R.E., Juhlin, K., Fransson, J. et al. Drug Saf (2016). doi:10.1007/s40264-016-0456-3

Open Access

Abstract

Introduction

A number of safety signals—complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)—have emerged with human papillomavirus (HPV) vaccines, which share a similar pattern of symptomatology. Previous signal evaluations and epidemiological studies have largely relied on traditional methodologies and signals have been considered individually.

Active treatment for food allergy

Aaron K. KobernickPress enter key for correspondence informationPress enter key to Email the author

, 

A. Wesley Burks

Open Access

DOI: http://dx.doi.org/10.1016/j.alit.2016.08.002

Article Info

• Abstract

• Full Text
• Images
• References

Abstract

Food allergy has grown in rapidly in prevalence, currently affecting 5% of adults and 8% of children. Management strategy is currently limited to 1) food avoidance and 2) carrying and using rescue intramuscular epinephrine/adrenaline and oral antihistamines in the case of accidental ingestion; there is no FDA approved treatment. Recently, oral, sublingual and epicutaneous immunotherapy have been developed as active treatment of food allergy, though none have completed phase 3 study.

Dr. Alan Goldsobel reviews the diagnosis and management of patients who have chronic cough

Dr. Alan Goldsobel reviews the diagnosis and management of patients who have chronic cough

ACAAICOLA

Dr. Maya Nanda describes how to do oral food challenges to evaluate food-allergic patients

Dr. Maya Nanda describes how to do oral food challenges to evaluate food-allergic patients
ACAAICOLA

Dr. Robbie Pesek discusses the basics of food allergy

Dr. Robbie Pesek discusses the basics of food allergy

ACAAICOLA

Dr. Lanny Rosenwasser discusses the pathogenesis of asthma

Dr. Lanny Rosenwasser discusses the pathogenesis of asthma

ACAAICOLA

Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin

Int. J. Mol. Sci. 2016, 17(4), 462; doi:10.3390/ijms17040462

Review

Yung-Sen Chang 1,2,3

 and Bor-Luen Chiang 2,4,* 

1 Department of Pediatrics, Taipei City Hospital Renai Branch, Taipei 106, Taiwan2 Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan3 School of Medicine, National Yang-Ming University, Taipei 112, Taiwan4 Department of Medical Research, National Taiwan University Hospital, Taipei 100, Taiwan

View Full-Text   |   Download PDF [1056 KB, uploaded 29 March 2016]   |   

 Browse Figure

 

Abstract

Sleep disturbance is common in children with atopic dermatitis (AD). It is a major factor leading to impaired quality of life in these patients and could have negative effects on neurocognitive function and behavior. However, the pathophysiology of sleep disturbance in children with AD is poorly understood, and there is no consensus on how to manage sleep problems in these patients. Pruritus and scratching could lead to sleep disruption but is unlikely the sole etiology. The circadian rhythm of cytokines, the immune system, and skin physiology such as transcutaneous water loss and skin blood flow might also play a role. Recent studies have suggested that melatonin could also be involved due to its multiple effects on sleep, immunomodulation, and anti-oxidant ability. Environmental factors should also be considered. In this review, we summarize the current understanding of the pathophysiology of sleep disturbance in children with AD, and discuss possible therapeutic implications.

View Full-Text   |   Download PDF 

Allergen Extracts and Standardization - ACAAI COLA Presentation

Dr. Greg Plunkett describes how allergen extracts are produced and standardized.

ACAAICOLA

Changes in symptoms of asthma and rhinitis by sensitization status over ten years in a cohort of young Chilean adults

• Vanessa Garcia-LarsenEmail author,
• James F. Potts,
• Stefano Del Giacco,
• Patricia Bustos,
• Patricia V. Diaz,
• Hugo Amigo,
• Manuel Oyarzun and
• Roberto J. Rona

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201616:116

DOI: 10.1186/s12890-016-0273-6

©  The Author(s). 2016

Open Peer Review reports

Abstract

Background

We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status.

Methods

One thousand one hundred ninety three Chilean adults subjects aged 22–28 living in a semi-rural area of central Chile answered a lifestyle and the European Community Respiratory Health Survey (ECRHS) questionnaires. Bronchial hyper-responsiveness (BHR) and skin prick test (SPT) to eight allergens were measured at baseline in 2001.

Cell-derived microparticles and the lung

Dario Nieri, Tommaso Neri, Silvia Petrini, Barbara Vagaggini, Pierluigi Paggiaro, Alessandro Celi

European Respiratory Review 2016 25: 266-277; DOI: 10.1183/16000617.0009-2016

• Article
• Figures & Data
• Info & Metrics
•  PDF

Abstract

Cell-derived microparticles are small (0.1–1 μm) vesicles shed by most eukaryotic cells upon activation or during apoptosis. Microparticles carry on their surface, and enclose within their cytoplasm, molecules derived from the parental cell, including proteins, DNA, RNA, microRNA and phospholipids. Microparticles are now considered functional units that represent a disseminated storage pool of bioactive effectors and participate both in the maintenance of homeostasis and in the pathogenesis of diseases.

Omalizumab's Impact on Total and Allergen-Specific IgE Levels: A Polyclonal Story

Free Access

Int Arch Allergy Immunol 2016;169:69-70
(DOI:10.1159/000444998)

Eckl-Dorna J.  Department of Otorhinolaryngology, General Hospital Vienna, Medical University of Vienna, Vienna, Austria  Corresponding Author

• Abstract
• FullText
• PDF

First-Page Preview