Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications

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Volume 47, Issue 2 February 2017 Pages 161–175 

• DOI: 10.1111/cea.12880View/save citation 
• Summary
  Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual patient disease triggers and response to therapy. Several asthma phenotypes have now been identified, each defined by a unique interaction between genetic and environmental factors, including inflammatory, clinical and trigger-related phenotypes.

Subtypes of asthma based on asthma control and severity: a latent class analysis

Respiratory Research 

RESEARCH

 

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• Elina M. S. Mäkikyrö,
• Maritta S. Jaakkola and
• Jouni J. K. JaakkolaEmail author

Respiratory Research201718:24

DOI: 10.1186/s12931-017-0508-y

Abstract

Background

Asthma subtyping is a complex new field of study. Usually both etiological and outcome factors of asthma have been used simultaneously for subtyping thus making the interpretation of the results difficult. Identification of subtypes of asthma based on questionnaire data only will be useful for both treatment of asthma and for research. Our objective was to identify asthma subtypes that capture both asthma control and severity based on easily accessible variables.

The current and future role of biomarkers in type 2 cytokine-mediated asthma management

Volume 47, Issue 2, February 2017 , Pages 148–160

Review

I. D. Pavord, S. Afzalnia, A. Menzies-Gow, L. G. Heaney

DOI: 10.1111/cea.12881

Summary

Assessment and management of asthma is complicated by the heterogeneous pathophysiological mechanisms that underlie its clinical presentation, which are not necessarily reflected in standardized management paradigms and which necessitate an individualized approach to treatment. This is particularly important with the emerging availability of a variety of targeted forms of therapy that may only be appropriate for use in particular patient subgroups. The identification of biomarkers can potentially aid diagnosis and inform prognosis, help guide treatment decisions and allow clinicians to predict and monitor response to treatment.

Effects of low-dose clarithromycin added to fluticasone on inflammatory markers and pulmonary function among children with asthma: A randomized clinical trial

Wan, Kong-Sang; Liu, Yu-Cheng; Huang, Che-Sheng; Su, Yu-Mao

Allergy & Rhinology, Volume 7, Number 3, 2016, pp. e131-e134(4)

Abstract:

Background: 

Macrolides exert anti-inflammatory and immunomodulatory effects beyond their purely antibacterial action, as demonstrated by several bronchial inflammatory disorders, including asthma. 

Adult Food Allergy Prevalence: Reducing Questionnaire Bias

Int Arch Allergy Immunol 2016;171:261-264 (DOI:10.1159/000453036)

Silva L.A. · Silva A.F.M. · Ribeiro Â.C. · Silva A.O. · Vieira F.A. · Segundo G.R.S.  Allergy and Immunology Division, Pediatrics Department, Universidade Federal de Uberlandia, Uberlandia, Brazil  Corresponding Author

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Abstract

Background: Food allergy (FA) prevalence has increased in the last decades, but epidemiologic studies could show overestimated results. The objective of this study is to estimate the prevalence of immediate FA in adults in a region of Central Brazil, using a questionnaire to try to reduce misperceptions about FA reaction. 

Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection

Int. J. Mol. Sci. 2017, 18(2), 259; doi:10.3390/ijms18020259

Ivan F. N. Hung ^1,2,* ,Anna Jinxia Zhang ¹

,Kelvin K. W. To ¹

,Jasper F. W. Chan ¹

,Shawn H. S. Zhu ¹

,Ricky Zhang ¹

,Tuen-Ching Chan ²

,Kwok-Hung Chan ¹

 andKwok-Yung Yuen ¹

View Full-Text   |    Download PDF [577 KB, uploaded 26 January 2017]   |   

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Abstract

Rhinovirus is a common cause of upper and lower respiratory tract infections in adults, especially among the elderly and immunocompromised. Nevertheless, its clinical characteristics and mortality risks have not been well described. A retrospective analysis on a prospective cohort was conducted in a single teaching hospital center over a one-year period. We compared adult patients hospitalized for pneumonia caused by rhinovirus infection with those hospitalized for influenza infection during the same period. All recruited patients were followed up for at least 3 months up to 15 months. Independent risk factors associated with mortality for rhinovirus infection were identified.

Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey

Clinical and Translational Allergy

• Vanessa Garcia-LarsenEmail authorView ORCID ID profile,
• Rhonda Arthur,
• James F. Potts,
• Peter H. Howarth,
• Matti Ahlström,
• Tari Haahtela,
• Carlos Loureiro,
• Ana Todo Bom,
• Grzegorz Brożek,
• Joanna Makowska,
• Marek L. Kowalski,
• Trine Thilsing,
• Thomas Keil,
• Paolo M. Matricardi,
• Kjell Torén,
• Thibaut van Zele,
• Claus Bachert,
• Barbara Rymarczyk,
• Christer Janson,
• Bertil Forsberg,
• Ewa Niżankowska-Mogilnicka and
• Peter G. J. Burney

Clinical and Translational Allergy20177:3

DOI: 10.1186/s13601-016-0140-9

Abstract

Background

Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases.

Objective

We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults.

Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps

Current Opinion in Allergy & Clinical Immunology:

February 2017 - Volume 17 - Issue 1 - p 17–22

doi: 10.1097/ACI.0000000000000332

RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner

Lee, Mingyu; Kim, Dae Woo; Shin, Hyun-Woo

Open Access

Abstract

Purpose of review: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disorder with a poorly understood pathophysiology. Recent findings show that epithelial-derived cytokines, including thymic stromal lymphopoietin, IL-33, and IL-25, can exacerbate Th2 immune responses, ultimately leading to recalcitrant chronic rhinosinusitis and nasal polyps. Although IL-25 is increased in CRSwNP, the targeting of IL-25 as a therapeutic strategy remains largely unexplored. In this review, we outline the many recent advances in our understanding of the association between IL-25 and CRSwNP.