Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor

Article | OPEN

• Tongde Wu
• , Julianne Huang
• , Patrick J. Moore
• , Michael S. Little
• , William G. Walton
• , Robert C. Fellner
• , Neil E. Alexis
• , Y. Peter Di
• , Matthew R. Redinbo
• , Stephen L. Tilley
•  & Robert Tarran

• Nature Communications 8, Article number: 14118 (2017)
• doi:10.1038/ncomms14118
• 
  
• Abstract

Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family member A1, BPIFA1, is a secreted innate defence protein. Here we show that BPIFA1 levels are reduced in sputum samples from asthmatic patients and that BPIFA1 is secreted basolaterally from healthy, but not asthmatic human bronchial epithelial cultures (HBECs), where it suppresses ASM contractility by binding to and inhibiting the Ca2+ influx channel Orai1. We have localized this effect to a specific, C-terminal α-helical region of BPIFA1.

Microbiome effects on immunity, health and disease in the lung

Shakti D Shukla¹, Kurtis F Budden¹, Rachael Neal¹ and Philip M Hansbro¹

Clinical & Translational Immunology (2017) 6, e133; doi:10.1038/cti.2017.6

Abstract

Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity worldwide. In the past decade, the interest in the role of microbiome in maintaining lung health and in respiratory diseases has grown exponentially. The advent of sophisticated multiomics techniques has enabled the identification and characterisation of microbiota and their roles in respiratory health and disease. Furthermore, associations between the microbiome of the lung and gut, as well as the immune cells and mediators that may link these two mucosal sites, appear to be important in the pathogenesis of lung conditions.

Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma

Italian Journal of Pediatrics 

RESEARCH

 

OPEN ACCES

• Michele Miraglia Del Giudice,
• Cristiana Indolfi,
• Michele Capasso,
• Nunzia Maiello,
• Fabio Decimo and
• Giorgio CiprandiEmail author

Italian Journal of Pediatrics201743:25

DOI: 10.1186/s13052-017-0340-5

Abstract

Background

Allergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction. Probiotics may exert anti-inflammatory and immune-modulatory activity. Thus, this study aimed at investigating whether a Bifidobacteria mixture could be able to relieve nasal symptoms, and affect quality of life (QoL) in children with AR and intermittent asthma due to Parietaria allergy.

An avoidable cause of thymoglobulin anaphylaxis

Allergy, Asthma & Clinical Immunology

CASE REPORT

 

OPEN ACCESS

• S. BrabantEmail author,
• A. Facon,
• F. Provôt,
• M. Labalette,
• B. Wallaert and
• C. Chenivesse

Allergy, Asthma & Clinical Immunology201713:13

DOI: 10.1186/s13223-017-0186-9

Abstract

Background

Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare.

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583 (Published 15 February 2017)Cite this as: BMJ 2017;356:i6583

Adrian R Martineau, professor of respiratory infection and immunity1 2, 

David A Jolliffe, postdoctoral research fellow1, 

Richard L Hooper, reader in medical statistics1, 

Lauren Greenberg, medical statistician1, 

John F Aloia, professor of medicine3, 

Peter Bergman, associate professor4, 

Gal Dubnov-Raz, consultant paediatrician5, 

Susanna Esposito, professor of paediatrics6, 

Davaasambuu Ganmaa, assistant professor7, 

Adit A Ginde, professor of emergency medicine8, 

Emma C Goodall, assistant professor9, 

Cameron C Grant, associate professor10, 

Christopher J Griffiths, professor of primary care1 2 11, 

Wim Janssens, professor of pneumonology12, 

Ilkka Laaksi, chief administrative medical officer13, 

Semira Manaseki-Holland, senior clinical lecturer14, 

David Mauger, professor of public health sciences and statistics15, 

David R Murdoch, professor of pathology16, 

Rachel Neale, associate professor17, 

Judy R Rees, assistant professor18, 

Steve Simpson Jr, postdoctoral research fellow19, 

Iwona Stelmach, professor of paediatric allergy20, 

Geeta Trilok Kumar, associate professor21, 

Mitsuyoshi Urashima, professor of molecular epidemiology22, 

Carlos A Camargo Jr, professor of emergency medicine, medicine, and epidemiology23

Author affiliations

1. Correspondence to: A R Martineau a.martineau@qmul.ac.uk

Abstract

Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.

Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.

Self-assessment of Allergic Rhinitis and Asthma (SACRA) Questionnaire-based Allergic Rhinitis Treatment Improves Asthma Control in Asthmatic Patients with Allergic Rhinitis

Internal Medicine
Vol. 56 (2017) No. 1 p. 31-39

Language:      English     Japanese   

• Previous Article
• |
 
• Next Article

http://doi.org/10.2169/internalmedicine.56.7251

ORIGINAL ARTICLES

Masanori Yasuo¹⁾, Yoshiaki Kitaguchi^{1) 2)}, Yoshimichi Komatsu³⁾, Mineyuki Hama¹⁾, Tomonobu Koizumi⁴⁾, Toshihiko Agatsuma⁵⁾, Takashi Ichiyama^{1) 6)}, Akane Kato^{1) 3)}, Hideaki Moteki⁷⁾, Masayuki Hanaoka¹⁾

1) The First Department of Internal Medicine, Shinshu University School of Medicine, Japan 2) Department of Respiratory Medicine, Okaya City Hospital, Japan 3) Department of Respiratory Medicine, Suwa Redcross Hospital, Japan 4) Comprehensive Cancer Center, Division of Clinical Oncology, Shinshu University School of Medicine, Shinshu University Hospital, Japan 5) Department of Respiratory Medicine, Shinshu Ueda Medical Center, Japan 6) Department of Respiratory Medicine, Nagano Municipal Hospital, Japan 7) Department of Otorhinolaryngology, Shinshu University School of Medicine, Japan

 Released on J-STAGE 20170101  

Keywords: allergic rhinitis, asthma, asthma control test (ACT), pulmonary function tests, SACRA questionnaire, visual analogue scale

•  Full Text PDF [209K]

• Abstracts
• References(24)
• Supplementary materials(3)

Objective This study was conducted to investigate whether the add-on treatment of allergic rhinitis (AR) based on the Self-assessment of Allergic Rhinitis and Asthma (SACRA) questionnaire for assessing AR control improves both AR and asthma control in asthmatic patients with AR.

Methods This multi-center prospective study was performed in Nagano prefecture, Japan. Two hundred five asthmatic patients and 23 respiratory physicians participated in the study. We administered add-on AR treatments based on the results of the SACRA questionnaire. After the first SACRA questionnaire, 67 asthmatic patients agreed to receive an add-on AR treatment. Three months after the AR treatment, a secondary SACRA questionnaire, asthma control test (ACT), and pulmonary function tests were performed.

Biomarkers for Monitoring Clinical Efficacy of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Allergic Asthma: an EAACI Position Paper.

Allergy. 2017 Feb 2. doi: 10.1111/all.13138. [Epub ahead of print]

Shamji MH1,2,3, Kappen JH1,2,4,3, Akdis M5, Jensen-Jarolim E6,7, Knol EF8, Kleine-Tebbe J9, Bohle B10, Chaker AM11,12, Till SJ13, Valenta R14, Poulsen LK15, Calderon MA1,2,3, Demoly P16, Pfaar O17, Durham LJ1,2,3, Schmidt-Weber CB11,12.

Author information

Abstract

Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma (1-12). AIT has disease modifying properties and confers long-term clinical benefit after cessation of treatment (6, 7, 13-17). AIT is routinely used in daily practice and can be administered either subcutaneously (SCIT) or sublingually (SLIT) (3-12).

Pollen and Spore Counting Part 2 (Barnes)

Dr. Barnes continues his discussion of how to do pollen spore counts. 

ACAAICOLA

Pollen and Spore Counting Part 1 (Barnes)

Dr. Charles Barnes describes how pollen and mold counts are performed

ACAAICOLA

Allergies in urban versus countryside settings in Poland as part of the Epidemiology of the Allergic Diseases in Poland (ECAP) study – challenge the early differential diagnosis

Original paper

Edyta Krzych-Fałta, Konrad Furmańczyk, Barbara Piekarska, Aneta Tomaszewska, Adam Sybilski, Bolesław K. Samoliński

Adv Dermatol Allergol 2016; XXXIII (5): 359-368

DOI: https://doi.org/10.5114/pdia.2016.61338

Article file

- Allergies in urban.pdf  [0.18 MB]

 

High-dose anti-histamine use and risk factors in children with urticaria

Pınar Uysal 1 ,  Sibelnur Avcil 2 ,  Duygu Erge 1 

1 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk Allerji ve Klinik İmmunoloji Bilim Dalı, Aydın, Türkiye 

2 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Aydın, Türkiye 

Turk Pediatri Ars 2016; 51: 198-203

DOI: 10.5152/TurkPediatriArs.2016.

Full Text (PDF)     Related Articles     Send a comment      Share

Abstract

Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.