May 5, 2017

Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study


    1. Previous article in issue: Overview of systematic reviews in allergy epidemiology

    Abstract
    Background
    The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients’ lives. It is freely available in 20 countries (iOS and Android platforms).
    Aims

    To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diarycould be identified and (iii) information gathered by this study could suggest novel research questions.
    Methods
    The Allergy Diary users were classified into six groups according to the baseline data that they entered into the App: (i) asymptomatic; (ii) nasal symptoms excluding rhinorrhea; (iii) rhinorrhea; (iv) rhinorrhea plus 1–2 nasal/ocular symptoms; (v) rhinorrhea plus ≥3 nasal/ocular symptoms; and (vi) rhinorrhea plus all nasal/ocular symptoms.

April 22, 2017

Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies

Allergy, Asthma & Clinical Immunology

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  • Paul RatnerEmail author,
  • Charles P. Andrews,
  • Frank C. Hampel,
  • Bruce Martin,
  • Dale E. Mohar,
  • Denis Bourrelly,
  • Parisa Danaietash,
  • Sara Mangialaio,
  • Jasper Dingemanse,
  • Abdel Hmissi and
  • Jay van Bavel

Abstract

Background
Antagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present findings on the efficacy and safety/tolerability of a CRTH2 antagonist (setipiprant) in participants with seasonal allergic rhinitis (AR) in a real-life setting over 2 weeks.

April 20, 2017

Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study

 
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  • I. Djuric-Filipovic,
  • Marco CaminatiEmail author,
  • D. Filipovic,
  • C. Salvottini and
  • Z. Zivkovic

Abstract
Background
Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sublingual allergen specific immunotherapy).