Could Eosinophilia predict clinical severity in nasal polyps?

Multidisciplinary Respiratory Medicine 

ORIGINAL RESEARCH ARTICLE

OPEN ACCESS

• Figen Aslan,
• Eren AltunEmail author,
• Serpil Paksoy and
• Gulay Turan

Multidisciplinary Respiratory Medicine201712:21

https://doi.org/10.1186/s40248-017-0102-7

©  The Author(s). 2017

Abstract

Background

Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. Aim of this study was to investigate the relation between mucosal and peripheral eosinophilia and their relation with disease severity in nasal polyps.

The history and epidemiology of Middle East respiratory syndrome corona virus

Multidisciplinary Respiratory Medicine

REVIEW

 

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Aisha M. Al-Osail 

and

Marwan J. Al-Wazzah

Multidisciplinary Respiratory Medicine 2017 12:20

https://doi.org/10.1186/s40248-017-0101-8\

Abstract

Corona viruses cause common cold, and infections caused by corona viruses are generally self-resolving. During the last 4 years, corona viruses have become the most important viruses worldwide because of the occurrence of several recent deaths caused by corona viruses in Saudi Arabia. Spread of the infection occurred worldwide; however, most cases of mortality have occurred in the Middle East.

Small airway bronchodilator response to different doses of salbutamol in 7-year-old children

Respiratory Research 

LETTER TO THE EDITOR

 

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• Dong Keon Yon,
• Hye Mi Jee,
• Eun Kyo Ha,
• Seung Jin Lee,
• Young-Ho Jung,
• Kyung Suk LeeEmail author and
• Man Yong HanEmail author

Respiratory Research201718:148

https://doi.org/10.1186/s12931-017-0632-8

Abstract

The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg.

Asthma referrals: a key component of asthma management that needs to be addressed

Journal of Asthma and Allergy Volume 2017:10 Pages 209—223

David Price, Leif Bjermer, David A Bergin, Rafael Martinez

¹Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK; ²Observational and Pragmatic Research Institute, Singapore; ³Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden; ⁴Novartis Ireland Limited, Dublin, Ireland; ⁵Novartis Pharma AG, Basel, Switzerland

Abstract: Heterogeneity of asthma and difficulty in achieving optimal control are the major challenges in the management of asthma. To help attain the best possible clinical outcomes in patients with asthma, several guidelines provide recommendations for patients who will require a referral to a specialist.

Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews

Clinical and Translational Allergy

REVIEW

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• Felix Asamoah†,
• Artemisia Kakourou†,
• Sangeeta DhamiEmail authorView ORCID ID profile,
• Susanne Lau,
• Ioana Agache,
• Antonella Muraro,
• Graham Roberts,
• Cezmi Akdis,
• Matteo Bonini,
• Ozlem Cavkaytar,
• Breda Flood,
• Kenji Izuhara,
• Marek Jutel,
• Ömer Kalayci,
• Oliver Pfaar and
• Aziz Sheikh

†Contributed equally

Clinical and Translational Allergy20177:25

https://doi.org/10.1186/s13601-017-0160-0

Abstract

Background

There is clinical uncertainty about the effectiveness and safety of allergen immunotherapy (AIT) for the treatment of allergic asthma.

Science, lifestyle, and human health: Challenging trilogy for the allergist/immunologist

• Allergy Asthma Proc
• PMC4929231

Allergy and Asthma Proceedings

Allergy Asthma Proc. 2016 Jul-Aug; 37(4): 265–267.

doi:  10.2500/aap.2016.37.3973 PMCID: PMC4929231

Joseph A. Bellanti, M.D. and Russell A. Settipane, M.D.

We live in a world awash with foreign substances, some inanimate and others, living microbes, in soil, water, and air that are potentially inimical to human health. Throughout evolution, deep seas and high peaks have long provided niches for these substances that are harsh yet permissive for the human species to both adapt to as well as to exploit not only by overwhelming them but at times by profiting from them and by yielding profit in return. Plants and animals, humans among them, for example, have had to cope with bacteria and parasites from the beginning stages of multicellular evolution due to the simple fact that they were here first. Successful adaptation to these foreign agents comprises the classic expressions of protective immunity....

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Health Economic Analysis of Allergen Immunotherapy (AIT) for the Management of Allergic Rhinitis, Asthma, Food Allergy and Venom Allergy: A Systematic Overview

• Miqdad Asaria, 
• Sangeeta Dhami, 
• Ronald van Ree, 
• Roy Gerth van Wijk, 
• Antonella Muraro, 
• Graham Roberts, 
• Aziz Sheikh

• Allergy
• (2017)

Abstract

Background

The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) for the management of allergic rhinitis, allergic asthma, IgE-mediated food allergy and venom allergy. To inform the development of clinical recommendations, we undertook systematic reviews to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT for these conditions. This paper focusses on synthesizing data and gaps in the evidence on the cost-effectiveness of AIT for these conditions.

Patient preferences for dry powder inhaler attributes in asthma and chronic obstructive pulmonary disease in France: a discrete choice experiment

BMC Pulmonary Medicine

RESEARCH ARTICLE

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Natalia HawkenEmail author,
• Saku Torvinen,
• Mohamed-Elmoctar Neine,
• Ikbel Amri,
• Mondher Toumi,
• Samuel Aballéa,
• Adam Plich and
• Nicolas Roche

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201717:99

DOI: 10.1186/s12890-017-0439-x

Abstract

Background

Dry powder inhalers (DPIs) are often used in asthma and chronic obstructive pulmonary disease (COPD) therapies. Using the discrete choice experiment (DCE) methodology, this study conducted in France was designed to assess patients’ preferences for different attributes of DPIs.

Zinc Acetate Lozenges May Improve the Recovery Rate of Common Cold Patients: An Individual Patient Data Meta-Analysis

EDITOR'S CHOICE

Harri Hemilä

 

James T. Fitzgerald

 

Edward J. Petrus

 

Ananda Prasad

Open Forum Infect Dis (2017) 4 (2): ofx059.

 

DOI:

https://doi.org/10.1093/ofid/ofx059

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Abstract

Background.

A previous meta-analysis of 3 zinc acetate lozenge trials estimated that colds were on average 40% shorter for the zinc groups. However, the duration of colds is a time outcome, and survival analysis may be a more informative approach. The objective of this individual patient data (IPD) meta-analysis was to estimate the effect of zinc acetate lozenges on the rate of recovery from colds.

Breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis are responsive to icatibant: findings from the Icatibant Outcome Survey

Allergy, Asthma & Clinical Immunology

RESEARCH

 

OPEN ACCESS

• Werner AbererEmail author,
• Marcus Maurer,
• Laurence Bouillet,
• Andrea Zanichelli,
• Teresa Caballero,
• Hilary J. Longhurst,
• Amandine Perrin,
• Irmgard Andresen and
• for the IOS Study Group

Allergy, Asthma & Clinical Immunology201713:31

DOI: 10.1186/s13223-017-0203-z

Abstract

Background

Patients with hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) experience recurrent attacks of cutaneous or submucosal edema that may be frequent and severe; prophylactic treatments can be prescribed to prevent attacks. However, despite the use of long-term prophylaxis (LTP), breakthrough attacks are known to occur. We used data from the Icatibant Outcome Survey (IOS) to evaluate the characteristics of breakthrough attacks and the effectiveness of icatibant as a treatment option.

Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study

BMC Pulmonary Medicine

RESEARCH ARTICLE

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Kodai KawamuraEmail author,
• Kazuya Ichikado,
• Yuko Yasuda,
• Keisuke Anan and
• Moritaka Suga

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201717:94

DOI: 10.1186/s12890-017-0437-z

Abstract

Background

Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a fatal condition without an established pharmaceutical treatment. Most patients are treated with high-dose corticosteroids and broad-spectrum antibiotics. Azithromycin is a macrolide with immunomodulatory activity and may be beneficial for treatment of acute lung injury. The objective of this study was to determine the effect of azithromycin on survival of patients with idiopathic AE of IPF.

Novel aspects in diagnostic approach to respiratory patients: is it the time for a new semiotics?

Multidisciplinary Respiratory Medicine

STATE OF THE ART

 

OPEN ACCESS

• Gino Soldati,
• Andrea SmargiassiEmail author,
• Alberto A. Mariani and
• Riccardo Inchingolo

Multidisciplinary Respiratory Medicine201712:15

DOI: 10.1186/s40248-017-0098-z

Abstract

Medical approach to patients is a fundamental step to get the correct diagnosis. The aim of this paper is to analyze some aspects of the reasoning process inherent in medical diagnosis in our era. Pathologic signs (anamnestic data, symptoms, semiotics, laboratory and strumental findings) represent informative phenomena to be integrated for inferring a diagnosis. Thus, diagnosis begins with “signs” and finishes in a probability of disease.