August 31, 2018

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

Authors Owens L, Laing IA, Zhang GTurner S, Le Souëf PN
Received 9 April 2018
Accepted for publication 4 May 2018
Published 13 August 2018 Volume 2018:11 Pages 173—180
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Luis Garcia-Marcos
Article has an altmetric score of 12

Louisa Owens,1,2 Ingrid A Laing,3,4 Guicheng Zhang,5,6 Stephen Turner,7 Peter N Le Souëf1

1School of Medicine, University of Western Australia, Perth, WA, Australia; 2School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW, Australia; 3Telethon Kids Institute, Perth, WA, Australia; 4School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia; 5School of Public Health, Curtin University, Perth, WA, Australia; 6Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, WA, Australia; 7School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK

August 28, 2018

Effects of nasal dilator strips on subjective measures of sleep in subjects with chronic nocturnal nasal congestion: a randomized, placebo-controlled trial

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Background
This exploratory study investigated effects of a new asymmetric butterfly-shaped prototype nasal dilator strip and the currently marketed clear Breathe Right Nasal Strip (BRNS) on subjective measures of nasal congestion and sleep quality.

August 22, 2018

The Role of Interleukin-19 in Contact Hypersensitivity.

Fujimoto Y, et al. Biol Pharm Bull. 2018.

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Abstract

Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells.

August 21, 2018

Unintentional injection to the bone with a pediatric epinephrine auto-injector

  • Allergy, Asthma & Clinical Immunology
  • Case report
  • Open Access

Abstract
Background
Skin-to-bone distance (STBD) in children prescribed a pediatric epinephrine auto-injector (EAI) for anaphylaxis is not commonly measured in practice. Recent evidence suggests that children with STBD less than the exposed needle length of available pediatric EAIs (dose: 0.15 mg, needle length: 12.7 mm) are at risk for unintentional injections to the bone during their use for an allergic emergency.

August 19, 2018

Risk of childhood cerebral palsy following prenatal exposure to ß2-adrenergic receptor agonist: A nationwide cohort study

PLoS One. 2018 Aug 16;13(8):e0202078.
    Lin Li, Ziliang Wang , Hong Liang, Fen Yang, Wei Yuan, Bizu Gelaye, Yongfu Yu, Maohua Miao , Mette Nørgaard, Jiong Li
Abstract
Background
Cerebral palsy (CP) is the most common physical developmental disability in childhood with a prevalence of 2 to 3 per 1000 live births. β2-adrenoreceptor agonist (β2AA) are widely used for the treatment of asthma. Maternal use of β2AAs may increase the risk of adverse neuro-psychiatric health outcomes in the offspring. No study, however, has evaluated the effect of prenatal exposure to β2AAs on the risk of CP.

August 16, 2018

Effectiveness of clarithromycin in patients with yellow nail syndrome

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  • Open Access
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Open Peer Review reports

Abstract

Background
Yellow nail syndrome (YNS) is a rare disease characterized by the triad of thickened, slow-growing yellow nails, lymphedema, and chronic respiratory manifestations. The cause of YNS is not known; however, it is suggested to be due to a congenital lymph abnormality. Since YNS is accompanied by chronic bronchial infection in more than half of patients, we hypothesized that treatment with clarithromycin (CAM) could be effective.

August 10, 2018

Allergic rhinitis and periodontitis among Korean adults: results from a nationwide population-based study (2013–2015)


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    Abstract

    Background
    The purpose of this study was to examine whether allergic rhinitis is associated with periodontal disease in a representative sample of elderly Korean people that was adjusted for socio-demographic factors, oral and general health behaviors, and systemic health status.

    July 24, 2018

    Seasonal asthma in Melbourne, Australia, and some observations on the occurrence of thunderstorm asthma and its predictability


    PLoS One. 2018; 13(4): e0194929.
    Jeremy D. Silver,  Michael F. Sutherland, Fay H. Johnston, Edwin R. Lampugnani, Michael A. McCarthy, Stephanie J. Jacobs, Alexandre B. Pezza, and Edward J. Newbigin

    Abstract
    We examine the seasonality of asthma-related hospital admissions in Melbourne, Australia, in particular the contribution and predictability of episodic thunderstorm asthma.

    July 23, 2018

    Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria

    Allergy, Asthma & Clinical Immunology 2018, 14:27 |
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    Abstract

    Background
    Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis.

    July 9, 2018

    Dupilumab: A New Paradigm for the Treatment of Allergic Diseases

    Sastre J1, Dávila I2
    1Allergy Service, Fundación Jiménez Díaz, and Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain
    2Institute for Biomedical Research of Salamanca (IBSAL), Allergy Service, University Hospital of Salamanca, and Department of Biomedical and Diagnostics Sciences, Faculty of Medicine, Salamanca, Spain
    Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the therapeutic options are often very limited. Treatment with systemic corticosteroids and immunosuppressants has adverse effects in the long term, and a significant proportion of patients remain refractory to therapy. In this context, the emerging biological drugs constitute a truly innovative therapeutic approach.

    Microbiome in the Gut-Skin Axis in Atopic Dermatitis

    Allergy Asthma Immunol Res. 2018 Jul; 10(4):354-362. English.
    Published online February 26, 2018.  

    So-Yeon Lee,1 Eun Lee,2 Yoon Mee Park,3 and Soo-Jong Hong1

    Abstract

    The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.



    July 2, 2018

    Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

    Allergy Asthma Immunol Res. 2018 Jul;10(4):300-353. English.
    https://doi.org/10.4168/aair.2018.10.4.300 
    Lei Cheng,1,2, Jianjun Chen,3, Qingling Fu,4, Shaoheng He,5, Huabin Li,6, Zheng Liu,7, Guolin Tan,8, Zezhang Tao,9, Dehui Wang,6, Weiping Wen,4, Rui Xu,4, Yu Xu,9, Qintai Yang,10, Chonghua Zhang,6, Gehua Zhang,10, Ruxin Zhang,11, Yuan Zhang,12,13,14, Bing Zhou,14, Dongdong Zhu,15,Luquan Chen,16 Xinyan Cui,1 Yuqin Deng,9 Zhiqiang Guo,11 Zhenxiao Huang,14 Zizhen Huang,10Houyong Li,6 Jingyun Li,12 Wenting Li,10 Yanqing Li,6 Lin Xi,12 Hongfei Lou,14 Meiping Lu,1 Yuhui Ouyang,12 Wendan Shi,9 Xiaoyao Tao,4 Huiqin Tian,1 Chengshuo Wang,14 Min Wang,12 Nan Wang,7Xiangdong Wang,12,13,14 Hui Xie,17 Shaoqing Yu,18 Renwu Zhao,11 Ming Zheng,14 Han Zhou,1 Luping Zhu,19 and Luo Zhang12,13,14
    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Abstract

    Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries.