February 17, 2019

POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project

Clinical and Translational Allergy

Review
Open Access

Jean BousquetEmail author View ORCID ID profile,

Josep M. Anto,

Isabella Annesi-Maesano,

Toni Dedeu,

Eve Dupas,

Jean-Louis Pépin,

Landry Stephane Zeng Eyindanga,

Sylvie Arnavielhe,

Julia Ayache,

Xavier Basagana,

Samuel Benveniste,

Nuria Calves Venturos,

Hing Kin Chan,

Mehdi Cheraitia,

Yves Dauvilliers,

Judith Garcia-Aymerich,

Ingrid Jullian-Desayes,

Chitra Dinesh,

Daniel Laune,

Jade Lu Dac,

Ismael Nujurally,

Giovanni Pau,

Robert Picard,

Xavier Rodo,

Renaud Tamisier,

Michael Bewick,

Nils E. Billo,

Wienczyslawa Czarlewski,

Joao Fonseca,

Ludger Klimek,

Oliver Pfaar and

Jean-Marc Bourez

Clinical and Translational Allergy20188:36

https://doi.org/10.1186/s13601-018-0221-z

Abstract

Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health).

Obstructive sleep apnea and comorbidities: a dangerous liaison

Multidisciplinary Respiratory Medicine

REVIEW

Maria R. Bonsignore, Pierpaolo Baiamonte, Emilia Mazzuca, Alessandra Castrogiovanni and Oreste Marrone

Multidisciplinary Respiratory Medicine 2019, 14:8

Abstract

Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged recently, and new conditions significantly associated with OSA are increasingly reported.

DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment

Smoothing out muscle in asthma

Asthma is often treated with drugs that reduce airway inflammation. Saunders et al. now show that fevipiprant, a prostaglandin D2 type 2 receptor antagonist, reduced smooth muscle mass in bronchial biopsies from asthma patients. Computational simulations of an asthmatic airway predicted that this decrease in airway smooth muscle mass was due to both amelioration of inflammation observed in a prior clinical trial together with direct effects on migration of myofibroblasts.

Age distribution and seasonality in acute eosinophilic pneumonia: analysis using a national inpatient database

Research article
Open Access
Open Peer Review

BMC Pulmonary Medicine

Koshi OtaEmail author View ORCID ID profile,

Yusuke Sasabuchi,

Hiroki Matsui,

Taisuke Jo,

Kiyohide Fushimi and

Hideo Yasunaga

BMC Pulmonary Medicine201919:38

Abstract

Background

Acute eosinophilic pneumonia (AEP) is a rare inflammatory lung disease. Previous studies have shown that most patients with AEP are aged 20 to 40 years, whereas several case studies have included older patients with AEP. These studies also suggested that AEP is more prevalent in summer, but they were limited due to their small sample sizes. We therefore investigated the age distribution and seasonality among patients with AEP using a national inpatient database.

Etiology analysis of nonspecific chronic cough in children of 5 years and younger

Chen, Xin, MS*; Peng, Wan-Sheng, MS; Wang, Lei, MS

Section Editor(s): Abdinia., Babak

Medicine: January 2019 - Volume 98 - Issue 3 - p e13910

doi: 10.1097/MD.0000000000013910

Research Article: Observational Study

This study aims to analyze the etiology of nonspecific chronic cough in children of 5 years and younger, in order to improve the diagnostic and treatment levels of pediatricians for nonspecific chronic cough in young children.

Health-related quality of life varies in different respiratory disorders: a multi-case control population based study

Research article
Open Access
Open Peer Review

Veronica Cappa,

Alessandro Marcon,

Gianfranco Di Gennaro,

Liliya Chamitava,

Lucia Cazzoletti,

Cristina Bombieri,

Morena Nicolis,

Luigi Perbellini,

Silvia Sembeni,

Roberto de Marco^,

Francesco Spelta,

Marcello Ferrari and

Maria Elisabetta ZanolinEmail author View ORCID ID profile

^Deceased

BMC Pulmonary Medicine201919:32

Open Peer Review reports

Abstract

Background and objective

Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).