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Clinical Allergy – Research Article
Editor's Choice - Free Access
Int Arch Allergy Immunol 2019;178:323–332
- Respiratory Research
- Research
- Open Access
June 8, 2019
Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis
June 7, 2019
SCIT Versus SLIT: Which One Do You Recommend, Doc?
Special FeaturePatient-Centered Focused ReviewSCIT Versus SLIT: Which One Do You Recommend, Doc?
Mohamad R.ChaabanMD, MSCR, MBAAhmedMansiBScJulia W.TrippleMDSarah K.WiseMD
The American Journal of the Medical Sciences
Allergic rhinitis is a prevalent condition that has a significant impact on the quality of life of many patients. When initial therapy fails to control the symptoms, allergen immunotherapy (AIT) has been suggested as an option by the Joint Task Force on Practice Parameters.
Bradykinin sensitizes the cough reflex via a B2receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase
Respiratory Research201920:110
Abstract
Background
Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization of the cough reflex and in airway obstruction.
Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough
- Respiratory Research
- Research
- Open Access
- Li Long†,
- Hongmei Yao†,
- Jing Tian†,
- Wei Luo,
- Xinxin Yu,
- Fang Yi,
- Qiaoli Chen,
- Jiaxing Xie,
- Nanshan Zhong†,
- Kian Fan Chung† and
- Kefang Lai†
†Contributed equally
Respiratory Research201920:112
Abstract
Background
The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly understood. We investigated the phenotypes of cough hypersensitivity by examining transient receptor potential ankyrin 1 (TRPA1)- and transient receptor potential vanilloid 1 (TRPV1)-mediated cough sensitivity in patients with chronic refractory cough.
June 6, 2019
Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis
- Clinical and Translational Allergy
- Review
- Open Access
- Ralph Mösges†,
- Antonio Valero Santiago†,
- Silke Allekotte,
- Nilufar Jahed,
- Anatoli Astvatsatourov,
- Angelika Sager and
- Jaime Sánchez-López
†Contributed equally
Clinical and Translational Allergy20199:29
Abstract
Background
Double-blind, placebo-controlled trials (DBPCTs) have confirmed the efficacy of allergen-specific immunotherapy (AIT) with depigmented-polymerized allergen extracts (DPAEs). This systematic review evaluates the efficacy of AIT using different allergens in different severity stages of rhinoconjunctivitis with or without asthma in the pollen studies and asthma and rhinitis in the house dust mite studies in comparison to placebo.
June 3, 2019
A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial
- Clinical and Translational Allergy
- Research
- Open Access
Clinical and Translational Allergy20199:27
Abstract
Background
Altered gut microbiota is implicated in cow’s milk allergy (CMA) and differs markedly from healthy, breastfed infants. Infants who suffer from severe CMA often rely on cow’s milk protein avoidance and, when breastfeeding is not possible, on specialised infant formulas such as amino-acid based formulas (AAF). Herein, we report the effects of an AAF including specific synbiotics on oral and gastrointestinal microbiota of infants with non-IgE mediated CMA with reference to healthy, breastfed infants.
Efficacy and safety of dupilumab for the treatment of uncontrolled asthma: a meta-analysis of randomized clinical trials
- Respiratory Research
- Research
- Open Access
Respiratory Research201920:108
Abstract
Background
Several recent clinical trials have assessed the effects of dupilumab in uncontrolled asthma, but reached no definite conclusion. We therefore conducted this meta-analysis to evaluate the overall efficacy and safety of dupilumab for the treatment of uncontrolled asthma.
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May 25, 2019
Identification of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus
Clinical and Translational Allergy
†Contributed equally
Abstract
Background
The identification of house dust mite (HDM) allergens and epitopes is important for allergy diagnosis and treatment. We sought to identify the Dermatophagoides pteronyssinus group 24 allergen (Der p 24) and to identify its immunodominant IgE epitope(s).
May 24, 2019
Immunosuppressive therapy with rituximab in common variable immunodeficiency
- Open Access
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary antibody deficiency in adulthood and is characterized by the marked reduction of IgG and IgA serum levels. Thanks to the successful use of polyvalent immunoglobulin replacement therapy to treat and prevent recurrent infections, non-infectious complications, including autoimmunity, polyclonal lymphoproliferation and malignancies, have progressively become the major cause of morbidity and mortality in CVID patients. The management of these complications is particularly challenging, often requiring multiple lines of immunosuppressive treatments. Over the last 5–10 years, the anti-CD20 monoclonal antibody (i.e., rituximab) has been increasingly used for the treatment of both autoimmune and non-malignant lymphoproliferative manifestations associated with CVID.
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