A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement

• Review
• Open Access
• 
  

• Frank E. van Boven, 
• Nicolette W. de Jong, 
• Gert-Jan Braunstahl, 
• Roy Gerth van Wijk & 
• Lidia R. Arends 

Clinical and Translational Allergy volume 10, Article number: 2 (2020)

Abstract

Background

Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures.

Change in the symptom profile treated as asthma – two cross-sectional studies twenty years apart

• Research
• Open Access

Respiratory Research

• Mihkel Pindus, 
• Hans Orru & 
• Rain Jõgi 

Respiratory Research volume 21, Article number: 41 (2020) 

Abstract

Aims

The aims of the study were to investigate prevalence trends of respiratory symptoms, asthma and asthma treatment among young adults in Estonia and to estimate changes in symptom profile among subjects who self-report asthma attacks or use asthma medications.

Comorbidities and survival in patients with chronic hypersensitivity pneumonitis

• Research
• Open Access

Respiratory Research

• Julia Wälscher, 
• Benjamin Gross, 
• Julie Morisset, 
• Kerri A. Johannson, 
• Martina Vasakova, 
• Jacques Bruhwyler & 
• Michael Kreuter 

Respiratory Research volume 21, Article number: 12 (2020) 

• details

Abstract

Introduction

Chronic Hypersensitivity Pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from repeated exposure to an offending antigen. Prognostication in cHP remains challenging, and the relationship between comorbidities and survival has yet to be characterized. The aim of this study was to describe the relationship between comorbid conditions and survival in patients with cHP.

Age-specific incidence of allergic and non-allergic asthma

• BMC Pulmonary Medicine
• Research article
• Open Access
• Open Peer Review

• Johanna Pakkasela, 
• Pinja Ilmarinen, 
• Jasmin Honkamäki, 
• Leena E. Tuomisto, 
• Heidi Andersén, 
• Päivi Piirilä, 
• Hanna Hisinger-Mölkänen, 
• Anssi Sovijärvi, 
• Helena Backman, 
• Bo Lundbäck, 
• Eva Rönmark, 
• Hannu Kankaanranta & 
• Lauri Lehtimäki 

BMC Pulmonary Medicine volume 20, Article number: 9 (2020) 

• details

Abstract

Background

Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was to assess age-specific incidence of allergic and non-allergic asthma.

Nasal Pathologies in Patients With Obstructive Sleep Apnoea

Acta Otorhinolaryngol Ital. 2019 Aug; 39(4): 250–256

G Magliulo 1, G Iannella 1, A Ciofalo 1, A Polimeni 2, M De Vincentiis 1, B Pasquariello 1, F Montevecchi 3, C Vicini 3

DOI: 10.14639/0392-100X-2173

Mean AHI value of patients without rhinitis and patients
with allergic rhinitis and non-allergic rhinitis diagnosis.

Summary: Nasal obstruction is a frequent condition in patients with obstructive sleep apnoea (OSA). Nasal obstruction leads to mouth breathing, which is thought to destabilise the upper airway and aggravate the condition. Three conditions could be considered as the cause of the nasal breathing obstruction: anatomical conditions of the nose (septum deviation, hypertrophy of the inferior turbinates), chronic rhinosinusitis (CRS) and chronic nasal inflammation caused by allergic rhinitis or non-allergic cellular rhinitis. In this prospective study, we present an evaluation of all these possible rhino-sinusal aspects in OSA patients to correlate different nasal pathologies with nasal obstruction.

Association between peripheral blood/bronchoalveolar lavage eosinophilia and significant oxygen requirements in patients with acute eosinophilic pneumonia

• BMC Pulmonary Medicine
• Research article
• Open Access
• Open Peer Review

• • 
    
• Joon Young Choi, 
• Jeong Uk Lim, 
• Ho Jung Jeong, 
• Ji Eun Lee & 
• Chin Kook Rhee 

BMC Pulmonary Medicine volume 20, Article number: 22 (2020)

Abstract

Background

We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia (AEP).

A single reaction-diffusion equation for the multifarious eruptions of urticaria

• PLoS Comput Biol
• v.16(1); 2020 Jan
• PMC6961880

PLoS Comput Biol. 2020 Jan; 16(1): e1007590.

Sungrim Seirin-Lee, Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide,

Abstract

Urticaria is a common skin disorder characterized by the rapid appearance and disappearance of local skin edema and flares with itching. It is characterized by various macroscopic skin eruptions unique to patients and/or subtypes of urticaria with respect to shape, size, color, and/or duration of eruptions. Nevertheless, the mechanism underlying multifarious eruptions in urticaria is largely unknown. The eruptions are believed to be evoked by histamine release from mast cells in the skin.

Diagnostic Approach for Suspected Allergic Cutaneous Reaction to a Permanent Tattoo

Silvestre JF, González-Villanueva I

Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain

J Investig Allergol Clin Immunol 2019; Vol 29(6) : 405-413doi: 10.18176/jiaci.0383

• Abstract

The last few decades have seen a notable increase in the number of people who have a tattoo. This practice is not free from complications. Most adverse effects appear early and are temporary, although they can occasionally develop later and be permanent and serious. Recent research has generated new knowledge on the composition of inks, their degradation over time, the immune activity that is stimulated, and the various clinical disorders that can arise. This information enables better approaches to diagnosis and management when complications arise. Diagnosing allergic reactions to permanent tattoo ink can be very challenging. This review aims to identify clinical and histological clues to help practitioners differentiate allergic reactions from other complications. We discuss the yield and appropriateness of skin tests and biopsies and propose an algorithm to guide the diagnostic process.

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Therapeutic Potential of Dupilumab in the Treatment of Chronic Rhinosinusitis with Nasal Polyps: Evidence to Date

Therapeutics and Clinical Risk Management » Volume 16

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Video abstract presented by Jean Kim.

Views: 3

Jean Kim,^1,2 Robert Naclerio<sup>1

1</sup>Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; ²Department of Medicine: Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Correspondence: Jean Kim
Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, Suite A102B, Baltimore, MD 21224, USA
Tel +1 410-550-0460
Fax +1 410-550-2871
Email jeankim@jhmi.edu

Abstract: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is one of the most severe forms of chronic rhinosinusitis. CRSwNP is characterized by nasal and facial congestion, loss of sense of smell, rhinorrhea, and post-nasal drip.

A contemporary look at allergic conjunctivitis

• Review
• Open Access
• 
  

Allergy, Asthma & Clinical Immunology

• Pascale Dupuis, 
• C. Lisa Prokopich, 
• Alexander Hynes & 
• Harold Kim 

Allergy, Asthma & Clinical Immunology volume 16, Article number: 5 (2020) 

Abstract

Ocular signs of (a) chronic perennial allergic conjunctivitis
(b–d) acute seasonal allergic conjunctivitis. 

Allergic eye disease is common, yet often overlooked in North America. In the U.S., up to 40% of the population is deemed to be affected and this number is growing. Symptoms and signs of ocular allergy can lead to decreased productivity and negatively impact quality of life (QoL). Various treatment options exist to achieve symptom control. For allergic conjunctivitis, ophthalmic agents include antihistamines, mast cell stabilizers, dual-activity agents, nonsteroidal anti-inflammatory drugs (NSAIDs), steroids and some off-label treatments. Immunotherapy is recommended as a therapeutic option.

Antibiotic hypersensitivity and adverse reactions: management and implications in clinical practice

• Research
• Open Access
• Allergy, Asthma & Clinical Immunology

• Anthony Jourdan, 
• Brijit Sangha, 
• Eric Kim, 
• Sohrab Nawaz, 
• Vikram Malik, 
• Radhika Vij & 
• Sudhir Sekhsaria 

Allergy, Asthma & Clinical Immunology volume 16, Article number: 6 (2020) 

Abstract

Background

Studies have shown the discrepancy between self-reported antibiotic allergies and true allergies. Inaccurate reporting of antibiotic hypersensitivities can limit treatment options and result in use of more expensive antibiotics and contribute to resistance.

Indoor mold odor in the workplace increases the risk of Asthma-COPD Overlap Syndrome: a population-based incident case–control study

• Research
• Open Access

Clinical and Translational Allergy

• Maritta S. Jaakkola, 
• Taina K. Lajunen & 
• Jouni J. K. Jaakkola 

Clinical and Translational Allergy volume 10, Article number: 3 (2020) 

• details

Abstract

Background

Previous studies have suggested an increased risk of asthma related to indoor dampness problems, but their role in the etiology of Asthma-COPD Overlap Syndrome has not been studied. We utilized a population-based incident case–control study to assess potential effect of indoor dampness and molds at home and at work on development of ACOS.