CSACI position statement: safety of topical calcineurin inhibitors in the management of atopic dermatitis in children and adults
Allergy, Asthma & Clinical Immunology 2013, 9:24 doi:10.1186/1710-1492-9-24
Published: 9 July 2013July 9, 2013
The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome
Clinical and Developmental Immunology Volume 2013 (2013), Article ID 160491, 6 pages http://dx.doi.org/10.1155/2013/160491
Review Article
The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Received 3 May 2013; Accepted 20 June 2013
Academic Editor: Guixiu Shi
Copyright © 2013 Yi-fan Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Sjogren's syndrome (SS) is a systemic, autoimmune disorder characterized by salivary insufficiency and lymphocytic infiltration of the exocrine glands. Even though the mechanism of its pathology and progression has been researched ever since its discovery, the roles of different parts of immune system remain inconclusive. There is no straightforward and simple theory for the pathogenesis and diagnosis of Sjogren’s syndrome because of the multiple kinds and functions of autoantibodies, changing proportion of different T-lymphocyte subsets with the progression of disease, unsuspected abilities of B lymphocytes discovered recently, crosstalk between cytokines connecting the factors mentioned previously, and genetic predisposition that contributes to the initiation of this disease. On the other hand, the number of significant reports and open-label studies of B-cell depletion therapy showing clinical efficacy in sjogren’s syndrome has continued to accumulate, which provides a promising future for the patients. In a word, further elucidation of the role of different components of the immune system will open avenues for better diagnosis and treatment of SS, whose current management is still mainly supportive.
Moisturizers for patients with atopic dermatitis
Moisturizers for patients with atopic dermatitis | |
Abstract
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with epidermal barrier defects which leads to dry skin that is easily disturbed by external exacerbating factors. It is now well established that moisturizers play an important role in preventing skin inflammation in AD, including reducing the amount of topical corticosteroid use. Thus, the use of moisturizers is currently recognized as one of standard treatment for AD. This review summarizes the role and classification of moisturizers. We also review some ingredients that are commonly added in moisturizers which are claimed to have an anti-inflammatory effects in AD.
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The development and pilot testing of the Self-management Programme of Activity, Coping and Education for Chronic Obstructive Pulmonary Disease (SPACE for COPD)
The development and pilot testing of the Self-management Programme of Activity, Coping and Education for Chronic Obstructive Pulmonary Disease (SPACE for COPD)
Original Research
(91) Total Article Views
Authors: Apps LD, Mitchell KE, Harrison SL, Sewell L, Williams JE, Young HML, Steiner M, Morgan M, Singh SJ
Published Date July 2013 Volume 2013:8 Pages 317 - 327
DOI: http://dx.doi.org/10.2147/COPD.S40414
| Received: | 16 November 2012  |
|---|---|
| Accepted: | 11 January 2013 |
| Published: | 09 July 2013 |
1National Institute of Health Research CLAHRC-LNR Pulmonary Rehabilitation Research Group, University Hospitals of Leicester NHS, Leicester, UK; 2Applied Research Centre, Health and Lifestyle Interventions, Coventry University, Coventry, UK
Purpose: There is no independent standardized self-management approach available for chronic obstructive pulmonary disease (COPD). The aim of this project was to develop and test a novel self-management manual for individuals with COPD.
Patients: Participants with a confirmed diagnosis of COPD were recruited from primary care.
Methods: A novel self-management manual was developed with health care professionals and patients. Five focus groups were conducted with individuals with COPD (N = 24) during development to confirm and enhance the content of the prototype manual. The Self-management Programme of Activity, Coping and Education for Chronic Obstructive Pulmonary Disease (SPACE for COPD) manual was developed as the focus of a comprehensive self-management approach facilitated by health care professionals. Preference for delivery was initial face-to-face consultation with telephone follow-up. The SPACE for COPD manual was piloted with 37 participants in primary care. Outcome measures included the Self-Report Chronic Respiratory Questionnaire, Incremental Shuttle Walk Test, and Endurance Shuttle Walking Test (ESWT); measurements were taken at baseline and 6 weeks.
Results: The pilot study observed statistically significant improvements for the dyspnea domain of the Self-Report Chronic Respiratory Questionnaire and ESWT. Dyspnea showed a mean change of 0.67 (95% confidence interval 0.23–1.11, P = 0.005). ESWT score increased by 302.25 seconds (95% confidence interval 161.47–443.03, P < 0.001).
Conclusion: This article describes the development and delivery of a novel self-management approach for COPD. The program, incorporating the SPACE for COPD manual, appears to provoke important changes in exercise capacity and breathlessness for individuals with COPD managed in primary care.
Keywords: self-management, primary care, Self-Report Chronic Respiratory Questionnaire, dyspnea, Endurance Shuttle Walking Test
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Dr. Sarah Anvari reviews the diagnosis and management of diseases of the sinuses.
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COLA (Conferences On-Line Allergy) is a live series of online allergy conferences held at Children's Mercy Hospital in Kansas City, Missouri. World experts give presentations on topics related to allergy and immunology. Live conferences are held on Monday and Friday from 10-noon (central time). They can be joined by going to http://www.childrensmercy.org/cola
COLA (Conferences On-Line Allergy) is a live series of online allergy conferences held at Children's Mercy Hospital in Kansas City, Missouri. World experts give presentations on topics related to allergy and immunology. Live conferences are held on Monday and Friday from 10-noon (central time). They can be joined by going to http://www.childrensmercy.org/cola
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Dr. Lanny Rosenwasser reviews the use of cytokine antibodies and antagonists to manage inflammatory diseases such as asthma.
COLA (Conferences On-Line Allergy) is a live series of online allergy conferences held at Children's Mercy Hospital in Kansas City, Missouri. World experts give presentations on topics related to allergy and immunology. Live conferences are held on Monday and Friday from 10-noon (central time). They can be joined by going to http://www.childrensmercy.org/cola
Dr. Jay Portnoy discusses some common misconceptions related to food allergy
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COLA (Conferences On-Line Allergy) is a live series of online allergy conferences held at Children's Mercy Hospital in Kansas City, Missouri. World experts give presentations on topics related to allergy and immunology. Live conferences are held on Monday and Friday from 10-noon (central time). They can be joined by going to http://www.childrensmercy.org/cola
July 8, 2013
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